Photoacoustic imaging (PAI) has seen immense growth in the past decade, providing unprecedented spatial resolution and functional information at depths in the optical diffusive regime.
PAI uniquely combines the advantages of optical excitation and acoustic detection. The hybrid imaging modality features high sensitivity to optical absorption and wide scalability of spatial resolution with the desired imaging depth. A major barrier to reaching its full potentials is lack of selective agents and systems for multiscale PAIs. Our group focuses on developing the next-generation PAI modalities and contrast agents for multiscale imaging applications, ranging from single molecule analysis to whole body imaging. We envision our research will push the boundaries of imaging resolution, depths, and sensitivity and specificity through the integrated efforts of chemists, physicists, biologists, and engineers across the Illinois campus.