William O'Brien

Description

Address

  • 4255 Beckman Institute
  • 405 North Mathews Avenue
  • Urbana, Illinois 61801

Biography

After receiving a Ph.D. from the University of Illinois in 1970, William D. O’Brien worked at the U.S. Food and Drug Administration for five years. Since 1975, he has been at the University of Illinois, where he was granted emeritus professor status in 2012. Previously, he was the Donald Biggar Willet professor of engineering, and a professor of electrical and computer engineering and of bioengineering, College of Engineering; professor of bioengineering, College of Medicine; and professor of nutritional sciences, College of Agricultural, Consumer, and Environmental Sciences. He remains the director of the Bioacoustics Research Laboratory, a position he has held since 1995. His research focuses on the mechanisms by which ultrasonic energy interacts with biological materials (fundamental ultrasonic bioeffects/therapy/risk assessment research) and applications of quantitative ultrasound imaging in biology, agriculture, and medicine (fundamental ultrasonic imaging research). He has been director of the NIH Radiation Biophysics and Bioengineering Oncology (T32) Training Program, has published 393 peer-reviewed papers, and is the principal investigator of an NIH MERIT (R37) AWARD. He has served as president the IEEE Ultrasonics, Ferroelectrics, and Frequency Control Society, editor-in-chief of the IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, and president of the American Institute of Ultrasound in Medicine. He is a Life Fellow of the Institute of Electrical and Electronics Engineers, a Fellow of the Acoustical Society of America, and a Fellow of the American Institute of Ultrasound in Medicine, and a Founding Fellow of the American Institute of Medical and Biological Engineering.

Honors

U of I College of Engineering's Engineering Council Award for Excellence in Advising (2004); Distinguished Service Award for 2003 from the IEEE Ultrasonics, Ferroelectrics and Frequency Control Society; Donald Biggar Willet Professor of Engineering, College of Engineering, University of Illinois (2003-present); The IEEE Third Millennium Medal (2000); IEEE Ultrasonics, Ferroelectrics, and Frequency Control Society's Achievement Award for 1998; IEEE Ultrasonics, Ferroelectrics, and Frequency Control Society Distinguished Lecturer (1997-1998).

Research

William D. O'Brien, Jr.'s research in the Beckman Institute deals with the mechanisms by which acoustic energy interacts with biological and nonbiological materials (physical acoustics), and applications of quantitative acoustic imaging in biology, agriculture, material science and medicine. The physical acoustics research activities focus on the fundamental understanding of how ultrasound interacts with biological materials, and specifically the role of heat and cavitation, and their relationship to the assessment of risk for the safe application of clinical ultrasound. The applications of quantitative acoustic imaging research activities with focus on the development of novel techniques to improve the quality of life including portable sonar systems for the Navy, defect detection in microwaveable food packages, in vivo ultrasonic microprobe sensor for tumor diagnosis, and subsurface detection of cultural artifacts. He is also involved in the development of an intelligent hearing aid, and an assessment of the propagation paths of acoustic energy into the human head under conditions of very high intensity acoustic pressure levels. The development and understanding of acoustic imaging and interaction concepts in medicine, biology and other materials contribute to the theme areas of Biological Intelligence.

Publications

  • 2016
    • Wang, H.; Gauthier, M.; Kelly, J. R.; Miller, R. J.; Xu, M.; O'Brien, W. D.; Cheng, J. J., Targeted Ultrasound-Assisted Cancer-Selective Chemical Labeling and Subsequent Cancer Imaging using Click Chemistry. Angewandte Chemie-International Edition 2016, 55, (18), 5452-5456, DOI:10.1002/anie.201509601.
  • 2015
    • Smith, B. W.; Simpson, D. G.; Sarwate, S.; Miller, R. J.; Erdman, J. W.; O’Brien, W. D., Contrast Ultrasound Imaging of the Aorta Does Not Affect Progression of Atherosclerosis or Cardiovascular Biomarkers in Apoe-/- Mice. Journal of Ultrasound in Medicine 2015, 34, 1115-1122.

    • Han, A. G.; O'Brien, W. D., Structure Function for High-Concentration Biophantoms of Polydisperse Scatterer Sizes. IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control 2015, 62, (2), 303-318, DOI:10.1109/Tuffc.2014.006629.

    • Coiado, O. C.; Buiochi, E. B.; O'Brien, W. D., Ultrasound-Induced Heart Rate Decrease: Role of the Vagus Nerve. IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control 2015, 62, (2), 329-336, DOI:10.1109/Tuffc.2014.006755.

    • Andre, M.; Heba, E.; Han, A.; Lin, S.; Wolfson, T.; Ang, B.; Gamst, A.; Erdman, J.; O'Brien, W.; Sirlin, C.; Loomba, R., Diagnosis and Quantification of Liver Steatosis with Quantitative Ultrasound Backscatter Technique. Medical Physics 2015, 42, (6), 3684-3684.
    • Gauthier, M.; Yin, Q.; Chen, J. J.; O'Brien, W. D., Design of Albumin-Coated Microbubbles Loaded with Polylactide Nanoparticles. Journal of Ultrasound in Medicine 2015, 34, (8), 1363-1372, DOI:10.7863/ultra.34.8.1363.
    • Han, A. G.; O'Brien, W. D., Structure Function: Theory, Ultrasonic Measurement, and Histology. 2015 IEEE International Ultrasonics Symposium (IUS) 2015, DOI:10.1109/Ultsym.2015.0171.
    • Lin, S. C.; Heba, E.; Wolfson, T.; Ang, B.; Gamst, A.; Han, A. G.; Erdman, J. W.; O'Brien, W. D.; Andre, M. P.; Sirlin, C. B.; Loomba, R., Noninvasive Diagnosis of Nonalcoholic Fatty Liver Disease and Quantification of Liver Fat using a New Quantitative Ultrasound Technique. Clinical Gastroenterology and Hepatology 2015, 13, (7), 1337-+, DOI:10.1016/j.cgh.2014.11.027.
    • Mcfarlin, B. L.; Kumar, V.; Bigelow, T. A.; Simpson, D. G.; White-Traut, R. C.; Abramowicz, J. S.; O'Brien, W. D., Beyond Cervical Length: A Pilot Study of Ultrasonic Attenuation for Early Detection of Preterm Birth Risk. Ultrasound in Medicine and Biology 2015, 41, (11), 3023-3029, DOI:10.1016/j.ultrasmedbio.2015.06.014.
    • McFarlin, B. L.; Balash, J.; Kumar, V.; Bigelow, T. A.; Pombar, X.; Abramowicz, J. S.; O'Brien, W. D., Development of an Ultrasonic Method to Detect Cervical Remodeling in vivo in Full-Term Pregnant Women. Ultrasound in Medicine and Biology 2015, 41, (9), 2533-2539, DOI:10.1016/j.ultrasmedbio.2015.04.022.
    • O'Brien, W. D.; Dunn, F., An Early History of High-Intensity Focused Ultrasound. Physics Today 2015, 68, (10), 40-45, DOI:10.1063/Pt.3.2947.
    • O'Brien, W. D., Jr., A Temporal View of Soft Tissue Quantitative Ultrasound. Physics Procedia 2015, 70, 1127-1130, DOI:10.1016/j.phpro.2015.08.241.
    • Smith, B. W.; Miller, R. J.; Wilund, K. R.; O'Brien, W. D.; Erdman, J. W., Effects of Tomato and Soy Germ on Lipid Bioaccumulation and Atherosclerosis in Apoe(-/-) Mice. Journal of Food Science 2015, 80, (8), H1918-H1925, DOI:10.1111/1750-3841.12968.
    • Smith, B. W.; Simpson, D. G.; Miller, R. J.; Erdman, J. W.; O'Brien, W. D., Contrast Ultrasound Imaging Does Not Affect Heat Shock Protein 70 Expression in Cholesterol-Fed Rabbit Aorta. Journal of Ultrasound in Medicine 2015, 34, (7), 1209-1216, DOI:10.7863/ultra.34.7.1209.
    • Wirtzfeld, L. A.; Ghoshal, G.; Rosado-Mendez, I. M.; Nam, K.; Park, Y.; Pawlicki, A. D.; Miller, R. J.; Simpson, D. G.; Zagzebski, J. A.; Oelze, M. L.; Hall, T. J.; O'Brien, W. D., Quantitative Ultrasound Comparison of Mat and 4t1 Mammary Tumors in Mice and Rats across Multiple Imaging Systems. Journal of Ultrasound in Medicine 2015, 34, (8), 1373-1383, DOI:10.7863/ultra.34.8.1373.
  • 2014
    • King, D. A.; O'Brien, W. D., Quantitative Analysis of Ultrasound Contrast Agent Postexcitation Collapse. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 2014, 61, 1237-1241.

    • Han, A. G.; Erdman, J. W.; Simpson, D. G.; Andre, M. P.; O'Brien, W. D., Early Detection of Fatty Liver Disease in Mice via Quantitative Ultrasound. 2014 IEEE International Ultrasonics Symposium (Ius) 2014 2363-2366, DOI:10.1109/Ultsym.2014.0589.

    • Coiado, O. C.; O'Brien, W. D., The Role of the Duty Factor in Ultrasound-Mediated Cardiac Stimulation. Journal of the Acoustical Society of America 2014, 136, (3), El231-El235, DOI:10.1121/1.4893332.

    • Andre, M. P.; Han, A. G.; Heba, E.; Hooker, J.; Loomba, R.; Sirlin, C. B.; Erdman, J. W.; O'Brien, W. D., Accurate Diagnosis of Nonalcoholic Fatty Liver Disease in Human Participants via Quantitative Ultrasound. 2014 IEEE International Ultrasonics Symposium (IUS) 2014 2375-2377, DOI:10.1109/Ultsym.2014.0592.

  • 2013
    • Gauthier, M.; King, D. A.; O'Brien, W. D., Evaluation of the Temporal Stability of Definity Using Double Passive Cavitation Detection. Journal of Ultrasound in Medicine 2013, 32, (9), 1535-1537, DOI: 10.7863/ultra.32.9.1535.

    • Gauthier, M.; King, D. A.; O'Brien, W. D., Influence of Microbubble Size on Postexcitation Collapse Thresholds for Single Ultrasound Contrast Agents Using Double Passive Cavitation Detection. IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control 2013, 60, (5), 877-879, DOI: 10.1109/tuffc.2013.2644.

    • Han, A. G.; Abuhabsah, R.; Miller, R. J.; Sarwate, S.; O'Brien, W. D., The Measurement of Ultrasound Backscattering from Cell Pellet Biophantoms and Tumors Ex Vivo. Journal of the Acoustical Society of America 2013, 134, (1), 686-693, DOI: 10.1121/1.4807576.

    • Kulsharova, G. K.; Lee, M. B.; Cheng, F.; Haque, M.; Choi, H.; Kim, K.; O'Brien, W. D.; Liu, G. L., In Vitro and in Vivo Imaging of Peptide-Encapsulated Polymer Nanoparticles for Cancer Biomarker Activated Drug Delivery. IEEE Transactions on Nanobioscience 2013, 12, (4), 304-310, DOI: 10.1109/tnb.2013.2274781.

    • Liao, F. Y.; O'Brien, W. D.; Jan, Y. K., Assessing Complexity of Skin Blood Flow Oscillations in Response to Locally Applied Heating and Pressure in Rats: Implications for Pressure Ulcer Risk. Physica a-Statistical Mechanics and Its Applications 2013, 392, (20), 4905-4915, DOI: 10.1016/j.physa.2013.06.007.

    • Pawlicki, A. D.; O’Brien, W. D., Method for Estimating Total Attenuation from a Spatial Map of Attenuation Slope for Quantitative Ultrasound Imaging. Ultrasonic Imaging 2013, 35, 162-172.

    • Smith, B. W.; King, J. L.; Miller, R. T.; Blue, J. P.; Sarwate, S.; O’Brien, W. D.; Erdman, J. W., Optimization of a Low Magnesium, Cholesterol-Containing Diet for the Development of Atherosclerosis in Rabbits. Journal of Food Research 2013, 2, 168-178.

    • Wirtzfeld, L. A.; Nam, K.; Labyed, Y.; Ghoshal, G.; Haak, A.; Sen-Gupta, E.; He, Z.; Hirtz, N. R.; Miller, R. J.; Sarwate, S.; Simpson, D. G.; Zagzebski, J. A.; Bigelow, T. A.; Oelze, M. L.; Hall, T. J.; O'Brien, W. D., Techniques and Evaluation from a Cross-Platform Imaging Comparison of Quantitative Ultrasound Parameters in an in Vivo Rodent Fibroadenoma Model. IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control 2013, 60, (7), 1386-1400, DOI: 10.1109/tuffc.2013.2711.

  • 2012
    • Johnson, C. A.; O’Brien Jr, W. D., The Angiogenic Response Is Dependent on Ultrasound Contrast Agent Concentration. Vascular Cell 2012, 4, 10.

    • Leithem, S. M.; Lavarello, R. J.; O'Brien, W. D.; Oelze, M. L., Estimating Concentration of Ultrasound Contrast Agents with Backscatter Coefficients: Experimental and Theoretical Aspects. Journal of the Acoustical Society of America 2012, 131, (3), 2295-2305.

    • Luchies, A. C.; Ghoshal, G.; O'Brien, W. D.; Oelze, M. L., Quantitative Ultrasonic Characterization of Diffuse Scatterers in the Presence of Structures That Produce Coherent Echoes. IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control 2012, 59, (5), 893-904.

    • Smith, B. W.; Simpson, D. G.; Sarwate, S.; Miller, R. J.; Blue, J. P.; Haak, A.; O'Brien, W. D.; Erdman, J. W., Contrast Ultrasound Imaging of the Aorta Alters Vascular Morphology and Circulating Von Willebrand Factor in Hypercholesterolemic Rabbits. Journal of Ultrasound in Medicine 2012, 31, (5), 711-720.

    • Borrelli, M. J.; O'Brien, W. D.; Hamilton, E.; Oelze, M. L.; Wu, J.; Bernock, L. J.; Tung, S.; Rokadia, H.; Culp, W. C., Influences of Microbubble Diameter and Ultrasonic Parameters on in Vitro Sonothrombolysis Efficacy. Journal of Vascular and Interventional Radiology 2012, 23, (12), 1677-1684.

    • Buiochi, E. B.; Miller, R. J.; Hartman, E.; Buiochi, F.; Bassani, R. A.; Costa, E. T.; O'Brien, W. D., Transthoracic Cardiac Ultrasonic Stimulation Induces a Negative Chronotropic Effect. IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control 2012, 59, (12), 2655-2661.

    • Nam, K.; Rosado-Mendez, I. M.; Wirtzfeld, L. A.; Kumar, V.; Madsen, E. L.; Ghoshal, G.; Pawlicki, A. D.; Oelze, M. L.; Lavarello, R. J.; Bigelow, T. A.; Zagzebski, J. A.; O'Brien, W. D.; Hall, T. J., Cross-Imaging System Comparison of Backscatter Coefficient Estimates from a Tissue-Mimicking Material. Journal of the Acoustical Society of America 2012, 132, (3), 1319-1324.

    • Borrelli, M. J.; O'Brien, W. D.; Bernock, L. J.; Williams, H. R.; Hamilton, E.; Wu, J. N.; Oelze, M. L.; Culp, W. C., Production of Uniformly Sized Serum Albumin and Dextrose Microbubbles. Ultrasonics Sonochemistry 2012, 19, (1), 198-208.

    • Forbes, M. M.; O'Brien, W. D., Development of a Theoretical Model Describing Sonoporation Activity of Cells Exposed to Ultrasound in the Presence of Contrast Agents. Journal of the Acoustical Society of America 2012, 131, (4), 2723-2729.

  • 2011
    • Han, A. G.; Abuhabsah, R.; Blue, J. P.; Sarwate, S.; O'Brien, W. D., Ultrasonic Backscatter Coefficient Quantitative Estimates from High-Concentration Chinese Hamster Ovary Cell Pellet Biophantoms. Journal of the Acoustical Society of America 2011, 130, (6), 4139-4147.

    • King, D. A.; O'Brien, W. D., Comparison between maximum radial expansion of ultrasound contrast agents and experimental postexcitation signal results. Journal of the Acoustical Society of America 2011, 129, (1), 114-121.

    • O'Brien Jr., W. D., Thermal and Other Non-cavitational Ultrasound Mechanisms, Ch 2. In Therapeutic Ultrasound: Mechanisms to Applications, Frenkel, V., Ed. Nova Science Publishers, Inc.: Hauppauege, NY, 2011.

    • Dapore, A. J.; King, M. R.; Harter, J.; Sarwate, S.; Oelze, M. L.; Zagzebski, J. A.; Do, M. N.; Hall, T. J.; O'Brien, W. D., Analysis of Human Fibroadenomas using Three-Dimensional Impedance Maps. IEEE Transactions on Medical Imaging 2011, 30, (6), 1206-1213.

    • Forbes, M. M.; Steinberg, R. L.; O'Brien, W. D., Frequency-Dependent Evaluation of the Role of Definity in Producing Sonoporation of Chinese Hamster Ovary Cells. Journal of Ultrasound in Medicine 2011, 30, (1), 61-69.

    • Johnson, C. A.; O'Brien Jr., W. D., Ultrasound Contrast Agent Concentration Affects the Angiogenic Response. Journal of Ultrasound in Medicine 2011, 30, 933-941.

    • Nam, K.; Rosado-Mendez, I. M.; Wirtzfeld, L. A.; Pawlicki, A. D.; Kumar, V.; Madsen, E. L.; Ghoshal, G.; Lavarello, R. J.; Oelze, M. L.; Bigelow, T. A.; Zagzebski, J. A.; O'Brien, W. D.; Hall, T. J., Ultrasonic Attenuation and Backscatter Coefficient Estimates of Rodent-Tumor-Mimicking Structures: Comparison of Results among Clinical Scanners. Ultrasonic Imaging 2011, 33, (4), 233-250.

    • Pawlicki, A. D.; Dapore, A. J.; Sarwate, S.; O'Brien, W. D., Three-Dimensional Impedance Map Analysis of Rabbit Liver. Journal of the Acoustical Society of America 2011, 130, (5), EL334-EL338.

  • 2010
    • Santin, M. D.; King, D. A.; Foiret, J.; Haak, A.; O'Brien, W. D.; Bridal, S. L., Encapsulated contrast microbubble radial oscillation associated with postexcitation pressure peaks. Journal of the Acoustical Society of America 2010, 127, (2), 1156-1164.

    • Johnson, C. A.; Sarwate, S.; Miller, R. J.; O'Brien, W. D., A Temporal Study of Ultrasound Contrast Agent-Induced Changes in Capillary Density. Journal of Ultrasound in Medicine 2010, 29, (9), 1267-1275.

    • King, D. A.; Haak, A.; Malloy, M. J.; Roberts, A. C.; Yoder, C. C.; O'Brien Jr., W. D., Determination of postexcitation thresholds for single ultrasound contrast agent microbubbles using double passive cavitation detection. Journal of the Acoustical Society of America 2010, 127, 3449-3455.

    • Anderson, J. J.; Herd, M.-T.; King, M. R.; Haak, A.; Hafez, Z. T.; Song, J.; Oelze, M. L.; Madsen, E. L.; Zagzebski, J. A.; O'Brien Jr., W. D.; Hall, T. J., Interlaboratory Comparison of Backscatter Coefficient Estimates for Tissue-mimicking Phantoms. Ultrasonic Imaging 2010, 32, 48-64.

    • Santin, M. D.; King, D. A.; Foiret, J.; Haak, A.; O'Brien Jr., W. D.; Bridal, S. L., Encapsulated Contrast Microbubble Radial Oscillation Associated with Postexcitation pressure peaks. Journal of the Acoustical Society of America 2010, 127, 1156-1164.

    • Smith, B. W.; Strakova, J.; King, J. L.; Erdman Jr., J. W.; O'Brien Jr., W. D., Validated Sandwich ELISA for the Quantification of von Willebrand Factor in Rabbit Plasma. Biomarker Insights 2010, 5, 119-127.

    • Teisseire, M.; Han, A. G.; Abuhabsah, R.; Blue, J. P.; Sarwate, S.; O'Brien, W. D., Ultrasonic backscatter coefficient quantitative estimates from Chinese hamster ovary cell pellet biophantoms. Journal of the Acoustical Society of America 2010, 128, (5), 3175-3180.

    • Wirtzfeld, L. A.; Ghoshal, G.; Hafez, Z. T.; Nam, K.; Labyed, Y.; Anderson, J. A.; Herd, M.-T.; Haak, A.; He, Z.; Miller, R. J.; Sarwate, S.; Simpson, D. G.; Zagzebski, J. A.; Bigelow, T. A.; Oelze, M. L.; Hall, T. J.; O'Brien Jr., W. D., Cross-imaging Platform Comparison of Ultrasonic Backscatter Coefficient Measurements of Live Rat Tumors. Journal of Ultrasound in Medicine 2010, 29, 1117-1123.

    • Wismer, M. G.; O'Brien, W. D., Evaluation of the vibrational modes of the human skull as it relates to bone-conducted sound. Journal of the Acoustical Society of America 2010, 128, (5), 2792-2797.

    • King, M. R.; Anderson, J. J.; Herd, M. T.; Ma, D.; Haak, A.; Wirtzfeld, L. A.; Madsen, E. L.; Zagzebski, J. A.; Oelze, M. L.; Hall, T. J.; O'Brien, W. D., Ultrasonic backscatter coefficients for weakly scattering, agar spheres in agar phantoms. Journal of the Acoustical Society of America 2010, 128, (2), 903-908.

    • McFarlin, B. L.; Bigelow, T. A.; Laybed, Y.; O'Brien, W. D.; Oelze, M. L.; Abramowicz, J. S., Ultrasonic attenuation estimation of the pregnant cervix: a preliminary report. Ultrasound in Obstetrics & Gynecology 2010, 36, (2), 218-225.

  • 2009
    • King, J. L.; Miller, R. J.; Blue, J. P.; O'Brien, W. D.; Erdman, J. W., Inadequate Dietary Magnesium Intake Increases Atherosclerotic Plaque Development in Rabbits. Nutrition Research 2009, 29, 343-349.

    • McNew, J.; Lavarello, R.; O'Brien, W. D., Sound Scattering from Two Concentric Fluid Spheres. Journal of the Acoustical Society of America 2009, 125, 1-4.

    • O'Brien, W. D.; Yang, Y.; Simpson, D. G., Threshold Estimation and Superthreshold Behavior of Ultrasound-Induced Lung Hemorrhage in Rats: Role of Age Dependency. Ultrasound in Medicine and Biology 2009, 35, (1), 129-135.

  • 2008
    • Oelze, M. L.; Miller, R. J.; Blue, J. P.; Zachary, J. F.; O'Brien, W. D., Estimation of the acoustic impedance of lung versus level of inflation for different species and ages of animals. Journal of the Acoustical Society of America 2008, 124, (4), 2340-2352.

    • O'Brien, W. D.; Deng, C. X.; Harris, G. R.; Herman, B. A.; Merritt, C. R.; Sanghvi, N.; Zachary, J. F., The risk of exposure to diagnostic ultrasound in postnatal subjects - Thermal effects. Journal of Ultrasound in Medicine 2008, 27, (4), 517-535.

    • Torno, M. D.; Kaminski, M. D.; Xie, Y. M.; Meyers, R. E.; Mertz, C. J.; Liu, X.; O'Brien, W. D.; Rosengart, A. J., Improvement of in vitro thrombolysis employing magnetically-guided microspheres. Thrombosis Research 2008, 121, (6), 799-811.

    • Ammi, A. Y.; Cleveland, R. O.; Mamou, J.; Wang, G.; Bridal, S. L.; O'Brien, W. D.; Zhang, T.; Wang, Q. M.; Xu, Z.; Fowlkes, J. B.; Cain, C. A., 2006 Outstanding Paper Award of the IEEE Ultrasonics, Ferroelectrics, and Frequency Control Society. Ieee Transactions on Ultrasonics Ferroelectrics and Frequency Control 2008, 55, (7), 1412-1414.

    • Forbes, M. M.; Steinberg, R. L.; O'Brien, W. D., Examination of Inertial Cavitation of Optison in Producing Sonoporation of Chinese Hamster Ovary Cells. Ultrasound in Medicine and Biology 2008, 34, (12), 2009-2018.

    • Bigelow, T. A.; McFarlin, B. L.; O'Brien, W. D.; Oelze, M. L., In vivo ultrasonic attenuation slope estimates for detecting cervical ripening in rats: Preliminary results. Journal of the Acoustical Society of America 2008, 123, (3), 1794-1800.

    • Fowlkes, J. B.; Abramowicz, J. S.; Church, C. C.; Holland, C. K.; Miller, D. L.; O'Brien, W. D.; Sanghvi, N. T.; Stratmeyer, M. E.; Zachary, J. E., American institute of ultrasound in medicine consensus report on potential bioeffects of diagnostic ultrasound. Journal of Ultrasound in Medicine 2008, 27, (4), 503-515.

    • Mamou, J.; Oelze, M. L.; O'Brien, W. D.; Zachary, J. F., Extended three-dimensional impedance map methods for identifying ultrasonic scattering sites. Journal of the Acoustical Society of America 2008, 123, (2), 1195-1208.

  • 2007
    • McFarlin, B. L.; Ji, H. L.; Chien, E. K. S.; O'Brien, W. D.; Oelze, M. L., Collagen and water concentration changes in the pregnant rat cervix. American Journal of Obstetrics and Gynecology 2007, 197, (6), S126-S126.

    • Church, C. C.; O'Brien, W. D., Evaluation of the threshold for lung hemorrhage by diagnostic ultrasound and a proposed new safety index. Ultrasound in Medicine and Biology 2007, 33, (5), 810-818.

    • Bigelow, T. A.; Miller, R. J.; Blue, J. P.; O'Brien, W. D., Hemorrhage near fetal rat bone exposed to pulsed ultrasound. Ultrasound in Medicine and Biology 2007, 33, (2), 311-317.

    • King, J. L.; Miller, R. J.; Blue, J. P.; Zachary, J. F.; O'Brien, W. D.; Erdman, J. W., Dietary magnesium intake, inflammation, and atherosclerotic plaque development in rabbits. FASEB Journal 2007, 21, (5), A359-A359.

    • O'Brien, W. D., Ultrasound-biophysics mechanisms. Progress in Biophysics & Molecular Biology 2007, 93, (1-3), 212-255.

  • 2006
    • O'Brien, W. D.; Yang, Y.; Simpson, D. G.; Frizzell, L. A.; Miller, R. J.; Blue, J. P.; Zachary, J. F., Threshold estimation of ultrasound-induced lung hemorrhage in adult rabbits and comparison of thresholds in mice, rats, rabbits and pigs. Ultrasound in Medicine and Biology 2006, 32, (11), 1793-1804.

    • Oelze, M. L.; O'Brien, W. D., Application of three scattering models to characterization of solid tumors in mice. Ultrasonic Imaging 2006, 28, (2), 83-96.

    • Zachary, J. F.; Blue, J. P.; Miller, R. J.; O'Brien, W. D., Vascular lesions and S-thrombomodulin concentrations from auricular arteries of rabbits infused with microbubble contrast agent and exposed to pulsed ultrasound. Ultrasound in Medicine and Biology 2006, 32, (11), 1781-1791.

    • Zachary, J. F.; Blue, J. P.; Miller, R. J.; Ricconi, B. J.; Eden, J. G.; O'Brien, W. D., Lesions of ultrasound-induced lung hemorrhage are not consistent with thermal injury. Ultrasound in Medicine and Biology 2006, 32, (11), 1763-1770.

    • McFarlin, B. L.; O'Brien, W. D.; Oelze, M. L.; Zachary, J. F.; White-Traut, R. C., Quantitative ultrasound assessment of the rat cervix. Journal of Ultrasound in Medicine 2006, 25, (8), 1031-1040.

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