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Sayeepriyadarshini Anakk

Associate Professor

Primary Affiliation

Extracellular Vesicle Imaging and Therapy


Status Affiliate Faculty

Home Department of Molecular and Integrative Physiology




  • Biography

    Sayeepriyadarshini Anakk is an associate professor in the Department of Molecular and Integrative Physiology.


    • B.S, pharmacy, Birla Institute of Technology & Sciences, Pilani, India
    • M.S., biological sciences, Birla Institute of Technology & Sciences, Pilani, India 
    • Ph.D., biochemistry, University of Texas, Graduate School of Biomedical Sciences at Houston 
  • Honors
    • 2020: Listed in "Teachers Ranked as Excellent"
    • 2016: Outstanding Advisor Award, Medical Scholars Program, UIUC, IL
    • 2016: Presidential Poster Judge, Annual Endocrine Society meeting, Boston, MA
    • 2016: Medical Scholars Program Outstanding Mentor Award
    • 2015: Invited Speaker, Nuclear Receptor signaling and cancer, Annual Endocrine Society meeting, San Diego, CA
    • 2015: Oral Session Chair, Nuclear Receptors and Kinases: Intertwined in Cancer, Obesity and Brain Disorders at the Annual Endocrine Society meeting, San Diego, CA
    • 2015: Travel Award, South East Lipid Research Conference, Atlanta, Georgia


  • Research

    Research Interests:

    • Endocrinology

    • Metabolic Regulation

    • Regulation of Gene Expression

    • Cancer

    • Metabolic Disorders/Diabetes

    Dr. Sayeepriyadarshini Anakk’s research focuses on understanding liver metabolism in normal and diseased states. Her goal is to investigate how bile acids and nuclear receptors maintain metabolic homeostasis and contribute to liver diseases, including cancer, using cell-based systems and genetically engineered mouse models.

  • 2021

    • Delgado ER, Erickson HL, Tao J, Monga SP, Duncan AW, Anakk S. (2021). Scaffolding protein IQGAP1 is dispensable, but its overexpression promotes hepatocellular carcinoma via YAP1 signaling. Mol Cell Biol. DOI: 10.1128/MCB.00596-20
    • Mathur B, Shahjahan A, Arif W, Chen Q, Hand NJ, Abramowitz LK, Schoonjans K, Rader DJ, Kalsotra A, Hanover JA, Parastoo A, Anakk S. (2021) Nuclear receptors FXR and SHP regulate protein N-glycan modifications in the liver. Science Advances. 21 Apr 2021. DOI: 10.1126/sciadv.abf4865
    • Nguyen JT, Riessen RR, Zhang T, Kieffer C, Anakk S. (2021) Deletion of intestinal SHP impairs short-term response to cholic acid challenge in male mice. Endocrinology. DOI: 10.1210/endocr/bqab063


    • Anakk S, Dean AE. (2020) Fxr-alpha Skips Alternatively in Liver Metabolism. Gastroenterology. DOI: 10.1053/j.gastro.2020.09.008
    • Mathur B, Arif W, Patton M, Faiyaz R, Liu J, Yeh J, Harpavat S, Schoonjans K, Kalsotra A, Wheatley A, Anakk S. (2020) Transcriptomic analysis across liver diseases reveals disease-modulating activation of constitutive androstane receptor in cholestasis. J Hep Reports. DOI: 10.1016/j.jhepr.2020.100140


    • Shahoei SH, Kim YC, Cler SJ, Ma L, Anakk S, Kemper JK, Nelson ER. (2019) Small Heterodimer Partner Regulates Dichotomous T Cell Expansion by Macrophages. Endocrinology. DOI: 10.1210/en.2019-00025


    • Bangru, S, Arif, W, Seimetz, J, Bhate, A, Chen, J, Rashan, EH, Carstens, RP, Anakk, S & Kalsotra, A 2018, 'Alternative splicing rewires Hippo signaling pathway in hepatocytes to promote liver regeneration', Nature Structural and Molecular Biology, vol. 25, no. 10, pp. 928-939. DOI: 10.1038/s41594-018-0129-2
    • Erickson HL, Anakk S. (2018) Identification of IQ motif-containing GTPase Activating Protein 1 as a regulator of long-term ketosis. JCI Insight. DOI: 10.1172/jci.insight.99866


    • Akinrotimi O, Riessen R, VanDuyne P, Park JE, Lee YK, Wong LJ, Zavacki AM, Schoonjans K, Anakk S. (2017) Shp deletion prevents hepatic steatosis and when combined with Fxr loss protects against type 2 diabetes. Hepatology. DOI: 10.1002/hep.29305.
    • Desai MS, Mathur B, Eblimit Z, Vasquez H, Taegtmeyer H, Karpen SJ, Penny DJ, Moore DD, Anakk S. (2017) Bile acid excess induces cardiomyopathy and metabolic dysfunctions in the heart. Hepatology 65(1):189-201. DOI: 10.1002/hep.28890


    • Bhate, A.; Parker, D.J.; Bebee, T.W.; Ahn, J.; Arif, W.; Rashan, E.H.; Chorghade, S.; Chau, A.; Lee, J.H.; Anakk, S.; Carstens, R.P., ESRP2 controls an adult splicing programme in hepatocytes to support postnatal liver maturation. Nature Communications 2015, 6. Article number 8768, doi:10.1038/ncomms9768.


    • Chow, E.C.; Magomedova, L.; Quach, H.P.; Patel, R.; Durk, M.R.; Fan, J.; Maeng, H.J.; Irondi, K.; Anakk, S.; Moore, D.D.; Cummins; C.L., Vitamin D receptor activation down-regulates the small heterodimer partner and increases CYP7A1 to lower cholesterol. Gastroenterology, 2014, 146(4), 1048-1059.
    • Kerr, T.A.; Matsumoto, Y.; Matsumoto, H.; Xie, Y.; Hirschberger, L.L.; Stipanuk, M.H.; Anakk, S.; Moore, D.D.; Watanabe, M.; Kennedy, S.; Davidson, N.O., Cysteine sulfinic acid decarboxylase regulation: A role for farnesoid X receptor and small heterodimer partner in murine hepatic taurine metabolism. Hepatology Research, 2014, 44(10).
    • Mathur, B.; Chau, A.; Wheeler, L.; Mathews, C.; Moore, D.D.; Anakk, S., SAT-0432: Constitutive Androstane Receptor, a Xeno-Sensor, Regulates dNTP Levels and Cellular Proliferation, 2014.


    • Anakk, S.; Bhosale, M.; Schmidt, V.A.; Johnson, R.L.; Finegold, M.J.; Moore, D.D., Bile acids activate YAP to promote liver carcinogenesis. Cell Reports, 2013, 5(4), 1060-1069.