Brenda Wilson

Description

Address

Biography

Education:

B.A. (Biochemistry and German), Barnard College/Columbia University, 1981

Deutscher Akademischer Austauschdienst, Ludwig-Maximilians Universität, Munich, Germany, Diplomarbeit 1981-1982

Ph.D. (Chemistry), Johns Hopkins University, 1989

Postdoctoral (Microbiology and Molecular Genetics), Harvard Medical School, 1989-1993

Research

Research Topics: Bacterial protein toxins, their interaction with host cells, their effects on intracellular signal transduction, and development of novel alternative anti-toxin therapeutics; human and nonhuman primate vaginal and gut microbial ecosystems (microbiomes) and their role in health and disease

Publications

  • 2016
    • Clemons NC; Luo S; Ho M; Wilson BA “Selective membrane redistribution and depletion of G -?q protein by Pasteurella multocida toxin” Toxins (2016), in press
    • Vlcková K; Gomez A; Petrželková KJ; Whittier CA; Todd AF; Yeoman CJ; Nelson KE; Wilson3 BA; Stumpf3 RM; Modry D; White BA; Leigh SR "Effect of antibiotic treatment on the gastrointestinal microbiota of free-ranging western lowland gorillas (Gorilla gorilla gorilla)" Microb Ecology (2016), DOI: 10.1007/s00248-016-0745-5
    • Gomez A; Petrzelkova K; Burns MB; Yeoman CJ; Amato KR; Vlckova K; Modry D; Todd A; Jost Robinson CA; Remis MJ; Torralba M; Morton E; Umana JD; Carbonero F; Gaskins HR; Nelson KE; Wilson3 BA; Stumpf3 RM; White BA; Leigh SR; Blekhman R. Gut Microbiome of Coexisting BaAka Pygmies and Bantu Reflects Gradients of Traditional Subsistence Patterns. Cell Reports 2016, 14, 9, p. 2142-2153.
    • Stumpf3, R. M., Gomez, A., Amato, K. R., Yeoman, C. J., Polk, J. D., Wilson3, B. A., Nelson, K. E., White, B. A. & Leigh, S. R. Microbiomes, metagenomics, and primate conservation: New strategies, tools, and applications. Biological Conservation 2016, 199, p. 56-66.
    • Gomez, A., Rothman, J. M., Petrzelkova, K., Yeoman, C. J., Vlckova, K., Umaña, J. D., Carr, M., Modry, D., Todd, A., Torralba, M., Nelson, K. E., Stumpf3, R. M., Wilson3, B. A., Blekhman, R., White, B. A. & Leigh, S. R. Temporal variation selects for diet-microbe co-metabolic traits in the gut of Gorilla spp. ISME Journal 2016, 10, 2, p. 514-526.
  • 2015
    • Gomez, A., Rothman, J. M., Petrzelkova, K., Yeoman, C. J., Vlckova, K., Umaña, J. D., Carr, M., Modry, D., Todd, A., Torralba, M., Nelson, K. E., Stumpf3, R. M., Wilson3, B. A., Blekhman, R., White, B. A. & Leigh, S. R. Temporal variation selects for diet-microbe co-metabolic traits in the gut of Gorilla spp. ISME Journal 2016, 10, 2, p. 514-526.
    • Amato KR; Yeoman CJ; Cerda G; Schmitt C; Cramer JD; Berg Miller ME; Gomez A; Turner T; Wilson3 BA; Stumpf3 RM; Nelson KE; White BA; Knight R; Leigh SR "Variable responses of human and nonhuman primate gut microbiomes to a Western diet" Microbiome (2015) 3(1):e53
    • Gomez, A., Petrzelkova, K., Yeoman, C. J., Vlckova, K., Mrázek, J., Koppova, I., Carbonero, F., Ulanov, A., Modry, D., Todd, A., Torralba, M., Nelson, K. E., Gaskins, H. R., Wilson3, B., Stumpf3, R. M., White, B. A. & Leigh, S. R. Gut microbiome composition and metabolomic profiles of wild western lowland gorillas (Gorilla gorilla gorilla) reflect host ecology. Molecular Ecology 2015, 24, 10, p. 2551-2565.
    • Liu, Y.; Zhao, Y. B.; Lyngso, J.; You, S. X.; Wilson, W. L.; Tu, H. H.; Boppart, S. A., Suppressing Short-Term Polarization Noise and Related Spectral Decoherence in All-Normal Dispersion Fiber Supercontinuum Generation. Journal of Lightwave Technology 2015, 33, (9), 1814-1820, DOI:10.1109/Jlt.2015.2397276.

    • Fan Y; Geren I; Dong J; Lou J; Conrad F; Wen WH; Smith TA; Smith LA; Ho M; Pires-Alves M; Wilson BA; Marks JD "Monoclonal antibodies targeting the alpha-exosite of botulinum neurotoxin serotype A inhibit catalytic activity" PLoS ONE (2015), 10(8):e0135306
    • Fan Y; Dong J; Lou J; Wen W; Conrad F; Geren I; Smith T; Smith L; Ho M; Pires-Alves M; Wilson BA; Marks JD "Monoclonal antibodies that inhibit the proteolytic activity of botulinum neurotoxin serotype B" Toxins (2015), 7(9):3405-3023
    • Wilson BA; Ho M (book chapter) "Evolutionary aspects of toxin-producing bacteria" In: The Comprehensive Sourcebook of Bacterial Protein Toxins, Fourth Edition, JE Alouf, D Ladant, and MR Popoff (Eds.), Elsevier Ltd., 2015, Waltham, Massachusetts, USA, pp. 3-39.
    • Wilson BA, Ho M. The biosecurity threat posed by biological toxins. In: Handbooks in Toxinology: Biological Toxins and Bioterrorism (2015), Gopalakrishnakone P, Balali-Mood M, Singh BR, Llewellyn L (Eds.), Springer Science, Dordrecht, pp. 141-183
    • Wilson BA; Bergmann S; Ho M; Orth JHC (book chapter) "Pasteurella multocida toxin" In: The Comprehensive Sourcebook of Bacterial Protein Toxins, Fourth Edition, JE Alouf, D Ladant, and MR Popoff (Eds.), Elsevier Ltd., 2015, Waltham, Massachusetts, USA, pp. 463-498.
    • Kapheim KM; Rao VD; Yeoman CJ; Wilson BA; White BA; Goldenfeld ND; Robinson GE "Castespecific differences in hindgut microbial communities of honey bees (Apis mellifera)" PLoS ONE (2015), 10(4):e0123911
  • 2014
    • Wilson BA, Ho M. Cargo-delivery platforms for targeted delivery of inhibitor cargos against botulism. Current Topics in Medicinal Chemistry (2014) 14(18):2081-2093 [PMID: 25335885]
    • Walther-Antonio MR; Jeraldo P; Berg Miller ME; Yeoman CJ; Nelson KE; Wilson BA; White BA; Chia N; Creedon DJ. Pregnancy's stronghold on the vaginal microbiome. PLoS ONE (2014), 9(6):e98514 [PMID: 24896831]
    • Brothers MC; Geissler B; Hisao GS; Wilson BA; Satchell KJF; Rienstra CM "Backbone 1H, 13C, and 15N and side-chain assignments of an effector membrane localization domain from Vibrio vulificus MARTX toxin" J Biomolecular NMR (2014) 8(2):225-228 [PMID: 23765285]
    • Brothers MC; Geissler B; Hisao GS; Satchell KJF; Wilson BA; Rienstra CM. Backbone 1H, 13C, and 15N and side-chain assignments of the membrane localization domain from Pasteurella multocida toxin. J Biomolecular NMR (2014), 8(1):221-224 [PMID: 23765284]
    • Patel V; Oh A; Voit A; Sultatos LG; Babu GJ; Wilson BA; Ho M; McArdle JJ "Altered active zones, vesicle pools, nerve terminal conductivity, and morphology during experimental MuSK myasthenia gravis" PLoS ONE (2014) 9(12):e110571
    • Yildirim, S., Yeoman, C. J., Janga, S. C., Thomas, S. M., Ho, M., Leigh, S. R., Consortium, P. M., White, B. A., Wilson3, B. A. & Stumpf3, R. M. Primate vaginal microbiomes exhibit species specificity without universal Lactobacillus dominance. ISME Journal 2014, 8, 12, p. 2431-2444.
    • Amato, K. R., Leigh, S. R., Kent, A., Mackie, R. I., Yeoman, C. J., Stumpf3, R. M., Wilson3, B. A., Nelson, K. E., White, B. A. & Garber, P. A. The role of gut microbes in satisfying the nutritional demands of adult and juvenile wild, black howler monkeys (Alouatta pigra). American Journal of Physical Anthropology 2014, 155, 4, p. 652-664.
  • 2013
    • Wilson BA, Ho M. Pasteurella multocida - from zoonoses to cellular microbiology. Clinical Microbiology Reviews (2013) 26(3):631-655 [PMID: 23824375]
    • Repella TL; Ho M; Wilson BA. Determinants of pH-dependent modulation of translocation in dermonecrotic G-protein-deamidating toxins. Toxins (2013), 5:1167-1179 [PMID: 23771204]
    • Gargi A; Tamilselvam B; Powers B; Prouty MG; Lincecum T; Eshraghi A; Maldonado-Arocho FJ; Wilson BA; Bradley KA; Blanke SR. Cellular interactions of the cytolethal distending toxins from Escherichia coli and Haemophilus ducreyi. J Biol Chem (2013), 288(11):7492-7505 [PMID: 23306199]
    • Oubrahim H; Wong A; Wilson BA; Chock PB. Pasteurella multocida toxin (PMT) upregulates CTGF which leads to mTORC1 activation in Swiss 3T3 cells. Cell Signaling (2013) 25(5):1136-1148 [PMID: 23415771]
    • Oubrahim H; Wong A; Wilson BA; Chock PB. Mammalian target of rapamycin complex 1 (mTORC1) plays a role in Pasteurella multocida toxin (PMT)-mediated protein synthesis and proliferation in Swiss 3T3 cells. J Biol Chem (2013), 288(4):2805-2815 [PMID: 23223576]
    • Zhu L; Kuang Z; Wilson BA; Lau GW "Competence-independent activity of pneumococcal EndA mediates degradation of extracellular DNA and NETs and is important for virulence" PLoS ONE (2013), 8(7):e70363
    • Walther-Antonio MRS; Chia N; Jeraldo P; Yeoman CJ; Nelson KE; Wilson BA; White BA; Creedon DJ "Vaginal microbiome remains stable during normal pregnancy" Reproductive Sciences (2013), 20(suppl): Feb issue
  • 2012
    • Ho M; Goh C-H; Brothers MC; Wang S; Young RL; Ou Y; Lui JN-M; Kalafatis M; Lan X; Wolf AE; Rienstra CM; Wilson BA. Glycine insertion at protease cleavage site of SNAP25 resists cleavage but enhances affinity for botulinum neurotoxin serotype A. Protein Science (2012), 21:318-326 [PMID: 22170566]
    • Orth JHC; Fester I; Siegert P; Weise M; Lanner U; Kamitani S; Tachibana T; Wilson BA; Schlosser A; Horiguchi Y; Aktories. Substrate specificity of Pasteurella multocida toxin for a-subunits of heterotrimeric G proteins. FASEB J (2012) 27(2):832-842 [PMID: 23150526]
    • Bannai Y; Aminova LR; Faulkner MJ; Ho M; Wilson BA. Rho/ROCK-dependent inhibition of 3T3- L1 adipogenesis by G-protein-deamidating dermonecrotic toxins through differential regulation of Notch1, Pref1/Dlk1, and ß-catenin signaling. Frontiers in Cellular and Infection Microbiology (2012), 2:80e [PMID: 22919671]
    • Wilson BA; Ho M (refereed review) "Pasteurella multocida toxin interaction with host cells: Entry and cellular effects" Current Topics Microbiol Immunol (2012) 361:93-111

Press

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