Rohit Bhargava



  • 4265 Beckman Institute
  • 405 North Mathews Avenue
  • Urbana, Illinois 61801


Rohit Bhargava is Founder Professor of Engineering in the Department of Bioengineering and affiliate professor in ECE, MechSE, ChBE and Chemistry as well as the Carle-Illinois College of Medicine. He serves at the Director of the Cancer Center at Illinois. Rohit’s research is focused on chemical imaging (infrared and Raman) and, more recently, on 3D printing. The major theme of his work is to uncover tumor-microenvironment factors in cancer progression using new technology. He received a dual B.Tech. degree (Chemical Engineering and Polymer Science and Engineering) from the Indian Institute of Technology, New Delhi and a PhD from Case Western Reserve University (in Macromolecular Science and Engineering). Subsequently, he was a Research Fellow at the National Institutes of Health and has been at Illinois since as Assistant Professor (2005-2011), Associate Professor (2011-2012) and Professor (2012-). In addition, Rohit has contributed to new approaches in team-based research and education as well. He founded the Cancer Center at Illinois, which is combining high quality technology and engineering with the field of oncology. Earlier in his career, Rohit was the first assistant professor hired into the new Bioengineering department at Illinois and played a key role in its establishment and development. Using real-world problems to inspire education and student development, among his recent educational innovations are the development of a challenge-inspired model for undergraduate education (Cancer Scholars Program), iFEAT program for graduate students, C*STAR collaborative program and National Institutes of Health (NIH) T32-funded graduate training program focusing on the Tissue Microenvironment. 


Beckman Vision and Spirit Award (2017)                                                                                               
Agilent Thought Leader Award (2016)                                                                                                
Fellow, American Institute for Medical and Biological Engineering (2015)                                        
Fellow, Society for Applied Spectroscopy (2015)                                                                                  
Craver Award, Coblentz Society (2013)                                                                                                 
FACSS Innovation Award (2012)                                                                                                          
Campus Award for Exceptional Promotion & Tenure Dossier (2011)                                         
Xerox Award for Faculty Research (2011)                                                                                       
Fellow, Center for Advanced Study (2010)                                                                                              
DoD Young Investigator (2007)                                                                                                              



Fundamental work in optical theory and numerical methods in his laboratory directly leads to new instrumentation and technologies in infrared imaging. Instruments developed in his laboratory have been used to provide new means to characterize and define cancer using chemical imaging. He led the first large scale validation of spectroscopic imaging for cancer pathology and recent innovations of stainless staining and systems approach to prognostication are developing the area of digital molecular pathology in cancer, brain and cardiovascular applications.


  • 2018-01-01
    • T.P. Wrobel, R. Bhargava “Infrared spectroscopic imaging advances as an analytical technology for biomedical sciences” Anal. Chem. In press (2018)
    • A. Ganguli, A. Ornob, N. Spegazzini, Y. Liu, G. Damhorst, T. Ghonge, B. Thornton, C. J. Konopka, W. Dobrucki, S. E. Clare, R. Bhargava, A. M. Smith, F. Kosari, R. Bashir “Pixelated spatial gene expression analysis from tissue” Nat. Comm. 9, Art. number: 202 (2018)
  • 2017-01-01
    • A.M. Andrews, R. Bhargava, R. Kennedy, L. Li, J.V. Sweedler “The Chemistry of Thought: The Role of the Measurement Sciences in Brain Research” Anal. Chem. 89, 4757-4757 (2017)
    • A. Ghosh, P. Mukherjee, S. Deb, R. Bhargava “Mapping Solvation Environments in Porous Metal Organic Frameworks with Infrared Chemical Imaging” J. Phys. Chem. Lett. 8, 5325–5330 (2017). DOI: 10.1021/acs.jpclett.7b02104
    • I.L. Rasskazov, N. Spegazzini, P. S. Carney, R. Bhargava “Dielectric Sphere Clusters as a Model to Understand Infrared Spectroscopic Imaging Data Recorded from Complex Samples” Anal. Chem. 89, 10813–10818 (2017). DOI: 10.1021/acs.analchem.7b02168
    • M.K. Gelber, M.R. Kole, N. Kim, N. Aluru, R. Bhargava “Quantitative Chemical Imaging Within Non-Planar Microfluidics” Anal. Chem. 89, 1716–1723 (2017) DOI: 10.1021/acs.analchem.6b03943
  • 2016-01-01
    • S. Tiwari, C. Hoke, V. Reddy, J. Raman, R. Bhargava “Translating infrared spectroscopic imaging for rapid analysis of biopsy samples using a discrete frequency approach” Anal. Chem. 88, 10183-10190 (2016) DOI: 10.1021/acs.analchem.6b02754
    • F. Ostadhossein, S.K. Misra, P. Mukherjee, A. Ostadhossein, E. Daza, S. Tiwari, S. Mittal, M.C. Gryka, R. Bhargava, D. Pan “Breast Cancer Therapy: Defined host-guest chemistry on Nanocarbon for sustained inhibition of cancer” Small 12, 5782-5782 (2016) DOI: 10.1002/smll.201601161
    • P. Mukherjee, S.J. Lim, T.P. Wrobel, R. Bhargava,* A.M. Smith* “Measuring and predicting the internal structure of semiconductor nanocrystals through Raman spectroscopy” J. Am. Chem. Soc. 138, 10887-10896 (2016) [*joint corresponding authors] DOI: 10.1021/jacs.6b03907
    • S.K. Misra, P. Mukherjee, H-H. Chang, S. Tiwari, M. Gryka, R. Bhargava, D. Pan “Multi-functionality Redefined with Colloidal Carotene Carbon Nanoparticles for Synchronized Chemical Imaging, Enriched Cellular Uptake and Therapy” Sci. Rep. 6, Article 29299 (2016)
    • F.N. Keith, R.K. Reddy, R. Bhargava “Development of a practical spatial-spectral analysis protocol for breast histopathology using Fourier transform infrared spectroscopic imaging” Faraday Discuss. 187, 43-68 (2016) DOI: 10.1039/c5fd00199d
    • R. Bhargava, A. Madabhushi “Emerging themes in image informatics and molecular analysis for digital pathology” Annu. Rev. Biomed. Engr. 18, 387–412 (2016) - invited
  • 2016
    • Bhargava, A.; Chan, V.; Kimball, E. S.; Oyer, D. S., Effects of Age on Glycemic Control in Patients with Type 2 Diabetes Treated with Insulin Detemir: A Post-Hoc Analysis of the Predictive (Tm) 303 Study. Drugs & Aging 2016, 33, (2), 135-141, DOI:10.1007/s40266-016-0342-9.
    • Dubowsky, S. E.; Deutsch, B.; Bhargava, R.; McCall, B. J., Infrared Emission Spectroscopy of Atmospheric-Pressure Ball Plasmoids. Journal of Molecular Spectroscopy 2016, 322, 1-8, DOI:10.1016/j.jms.2016.02.005.
    • Kunze, C.; Mentzel, H. J.; Krishnamurthy, R.; Fleck, R.; Stenzel, M.; Bhargava, R.; Burrowes, D.; Sutter, G.; Schultze-Mosgau, M.; Santiuste, M.; Hahn, G., Pharmacokinetics and Safety of Macrocyclic Gadobutrol in Children Aged Younger Than 2 Years Including Term Newborns in Comparison to Older Populations. Investigative Radiology 2016, 51, (1), 50-57, DOI:10.1097/Rli.0000000000000204.
    • Kwak, J. T.; Hewitt, S. M.; Kajdacsy-Balla, A. A.; Sinha, S.; Bhargava, R., Automated Prostate Tissue Referencing for Cancer Detection and Diagnosis. BMC Bioinformatics 2016, 17, DOI:ARTN 227 10.1186/s12859-016-1086-6.
    • Misra, S. K.; Mukherjee, P.; Ohoka, A.; Schwartz-Duval, A. S.; Tiwari, S.; Bhargava, R.; Pan, D., Vibrational Spectroscopy and Imaging for Concurrent Cellular Trafficking of Co-Localized Doxorubicin and Deuterated Phospholipid Vesicles. Nanoscale 2016, 8, (5), 2826-2831, DOI:10.1039/c5nr07975f.
    • Saha, M.; Arun, I.; Basak, B.; Agarwal, S.; Ahmed, R.; Chatterjee, S.; Bhargava, R.; Chakraborty, C., Quantitative Microscopic Evaluation of Mucin Areas and Its Percentage in Mucinous Carcinoma of the Breast Using Tissue Histological Images. Tissue & Cell 2016, 48, (3), 265-273, DOI:10.1016/j.tice.2016.02.005.
  • 2015-01-01
    • L. S. Leslie, T. P. Wrobel, D. Mayerich, S. Bindra, R. Emmadi, R. Bhargava “High definition infrared spectroscopic imaging for lymph node histopathology” PLoS One 10:e0127238 (2015). DOI: doi: 10.1371/journal.pone.0127238
    • M. K. Gelber, R. Bhargava “Monolithic multilayer microfluidics via sacrificial molding of 3D-printed isomalt” Lab Chip 15, 1736–1741 (2015). DOI: 10.1039/c4lc01392a.
    • J. T. Kwak, A. Kajdacsy-Balla, V. Macias, M. J. Walsh, S. Sinha, R. Bhargava “Improving prediction of prostate cancer recurrence using chemical imaging” Sci. Rep. 5, 8758 (2015).
  • 2015
    • Yeh, K.; Kenkel, S.; Liu, J. N.; Bhargava, R., Fast Infrared Chemical Imaging with a Quantum Cascade Laser. Analytical Chemistry 2015, 87, (1), 485-493, DOI:10.1021/Ac5027513.

    • Tiwari, S.; Zong, X. Y.; Holton, S. E.; Prasanth, K. V.; Bhargava, R., Fourier Transform Infrared (FT-IR) Spectroscopy and Imaging of the Nucleus to Characterize DNA Contributions in Different Phases of the Cell Cycle. Medical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging 2015, 9417, DOI:Unsp 941720 DOI:10.1117/12.2082347.

    • Tiwari, S.; Reddy, V. B.; Bhargava, R.; Raman, J., Computational Chemical Imaging for Cardiovascular Pathology: Chemical Microscopic Imaging Accurately Determines Cardiac Transplant Rejection. Plos One 2015, 10, (5), DOI:ARTN e0125183 DOI:10.1371/journal.pone.0125183.

    • Leslie, L. S.; Kadjacsy-Balla, A.; Bhargava, R., High-Definition Fourier Transform Infrared Spectroscopic Imaging of Breast Tissue. Medical Imaging 2015: Digital Pathology 2015, 9420, DOI:Artn 94200i DOI:10.1117/12.2082461.

    • Kwak, J. T.; Kajdacsy-Balla, A.; Macias, V.; Walsh, M.; Sinha, S.; Bhargava, R., Improving Prediction of Prostate Cancer Recurrence Using Chemical Imaging. Scientific Reports 2015, 5, DOI:Artn 8758 DOI:10.1038/Srep08758.

    • Han, J.; Qiu, W.; Tiwari, S.; Bhargava, R.; Gao, W.; Xing, B. S., Consumer-Grade Polyurethane Foam Functions as a Large and Selective Absorption Sink for Bisphenol a in Aqueous Media. Journal of Materials Chemistry A 2015, 3, (16), 8870-8881, DOI:10.1039/C5ta00868a.

    • Gelber, M. K.; Bhargava, R., Monolithic Multilayer Microfluidics via Sacrificial Molding of 3d-Printed Isomalt. Lab on a Chip 2015, 15, (7), 1736-1741, DOI:10.1039/C4lc01392a.

    • DeVetter, B. M.; Mukherjee, P.; Murphy, C. J.; Bhargava, R., Measuring Binding Kinetics of Aromatic Thiolated Molecules with Nanoparticles Via Surface-Enhanced Raman Spectroscopy. Nanoscale 2015, 7, (19), 8766-8775, DOI:10.1039/C5nr01006c.

    • Deutsch, B.; Reddy, R.; Mayerich, D.; Bhargava, R.; Carney, P. S., Compositional Prior Information in Computed Infrared Spectroscopic Imaging. Journal of the Optical Society of America a-Optics Image Science and Vision 2015, 32, (6), 1126-1131, DOI:10.1364/Josaa.32.001126.

    • Chng, B. X. K.; van Dijk, T.; Bhargava, R.; Carney, P. S., Enhancement and Extinction Effects in Surface-Enhanced Stimulated Raman Spectroscopy. Physical Chemistry Chemical Physics 2015, 17, (33), 21348-21355, DOI:10.1039/c4cp05089d.
    • Leslie, L. S.; Wrobel, T. P.; Mayerich, D.; Bindra, S.; Emmadi, R.; Bhargava, R., High Definition Infrared Spectroscopic Imaging for Lymph Node Histopathology. Plos One 2015, 10, (6), DOI:UNSP e0127238 10.1371/journal.pone.0127238.
    • Liu, J. N.; Bhargava, R.; Cunningham, B. T., Discrete-Frequency Infrared Microspectroscopy using Monolithically Integrated Photonic Filters. 2015 Photonics Conference (IPC) 2015.
    • Mukherjee, P.; Misra, S. K.; Gryka, M. C.; Chang, H. H.; Tiwari, S.; Wilson, W. L.; Scott, J. W.; Bhargava, R.; Pan, D., Tunable Luminescent Carbon Nanospheres with Well-Defined Nanoscale Chemistry for Synchronized Imaging and Therapy. Small 2015, 11, (36), 4691-4703, DOI:10.1002/smll.201500728.
    • Ray, P. S.; Jensen, T. W.; Ray, T.; Gholamalamdari, O.; Tsai, C. Y.; Kim, B.; Bhargava, R.; Prasanth, K. V., Foxc1/Foxa1 Transcriptional Balance in Breast Cancer: From Acquisition of Mesenchymal and Stem Cell Traits to Occult Lymph Node Independent Breast Cancer Metastasis. Cancer Research 2015, 75, DOI:10.1158/1538-7445.Sabcs14-P1-07-30.
    • Tiwari, S.; Reddy, V. B.; Bhargava, R.; Raman, J., Computational Chemical Imaging for Cardiovascular Pathology: Chemical Microscopic Imaging Accurately Determines Cardiac Transplant Rejection. Plos One 2015, 10, (5), DOI:ARTN e0125183 10.1371/journal.pone.0125183.
    • Wu, Q.; Madany, P.; Akech, J.; Dobson, J. R.; Douthwright, S.; Browne, G.; Colby, J. L.; Winter, G. E.; Bradner, J. E.; Pratap, J.; Sluder, G.; Bhargava, R.; Chiosea, S. I.; van Wijnen, A. J.; Stein, J. L.; Stein, G. S.; Lian, J. B.; Nickerson, J. A.; Imbalzano, A. N., The Swi/Snf Atpases Are Required for Triple Negative Breast Cancer Cell Proliferation. Journal of Cellular Physiology 2015, 230, (11), 2683-2694, DOI:10.1002/jcp.24991.
  • 2014
    • DeVetter, B. M.; Bhargava, R.; Murphy, C. J., Computational Study of the Surface-Enhanced Raman Scattering from Silica-Coated Silver Nanowires. Photochemistry and Photobiology 2014, 90, (2), 415-418, DOI: 10.1111/php.12205.

    • Holton, S. E.; Bergamaschi, A.; Katzenellenbogen, B. S.; Bhargava, R., Integration of Molecular Profiling and Chemical Imaging to Elucidate Fibroblast-Microenvironment Impact on Cancer Cell Phenotype and Endocrine Resistance in Breast Cancer. Plos One 2014, 9, (5), e96878.

    • Mayerich, D.; van Dijk, T.; Walsh, M.; Schulmerich, M.; Carney, P. S.; Bhargava, R., Quantitative Confocal Phase Imaging by Synthetic Optical Holography. Analyst 2014, 10, 1039.

    • Wu, Q.; Madany, P.; Akech, J.; Dobson, J.; Douthwright, S.; Browne, G.; Colby, J. L.; Schnabl, J. M.; Pratap, J.; Sluder, G.; Bhargava, R.; Chiosea, S. I.; Van Wijnen, A. J.; Stein, J. L.; Stein, G. S.; Lian, J. B.; Nickerson, J. A.; Imbalzano, A. N., Brg1 Promotes Breast Cancer by Reprogramming Lipid Biosynthesis. Molecular Biology of the Cell 2014, 25.

    • Rosenberg, A.; Surya, J.; Liu, R. Y.; Streyer, W.; Law, S.; Leslie, L. S.; Bhargava, R.; Wasserman, D., Flat Mid-Infrared Composite Plasmonic Materials Using Lateral Doping-Patterned Semiconductors. Journal of Optics 2014, 16, (9), DOI:Artn 094012 DOI:10.1088/2040-8978/16/9/094012.

    • Mayerich, D. M.; Walsh, M.; Kadjacsy-Balla, A.; Mittal, S.; Bhargava, R., Breast Histopathology Using Random Decision Forests-Based Classification of Infrared Spectroscopic Imaging Data. Medical Imaging 2014: Digital Pathology 2014, 9041, DOI:Artn 904107 DOI:10.1117/12.2043783.

    • Mayerich, D.; Van Dijk, T.; Walsh, M. J.; Schulrnerich, M. V.; Carney, P. S.; Bhargava, R., On the Importance of Image Formation Optics in the Design of Infrared Spectroscopic Imaging Systems. Analyst 2014, 139, (16), 4031-4036, DOI:10.1039/C3an01687k.

    • Liu, J. N.; Schulmerich, M. V.; Bhargava, R.; Cunningham, B. T., Sculpting Narrowband Fano Resonances Inherent in the Large-Area Mid-Infrared Photonic Crystal Microresonators for Spectroscopic Imaging. Optics Express 2014, 22, (15), 18142-18158, DOI:10.1364/Oe.22.018142.

    • DeVetter, B. M.; Sivapalan, S. T.; Patel, D. D.; Schulmerich, M. V.; Murphy, C. J.; Bhargava, R., Observation of Molecular Diffusion in Polyelectrolyte-Wrapped Sers Nanoprobes. Langmuir 2014, 30, (29), 8931-8937, DOI:10.1021/La501944k.

    • Baker, M. J.; Trevisan, J.; Bassan, P.; Bhargava, R.; Butler, H. J.; Dorling, K. M.; Fielden, P. R.; Fogarty, S. W.; Fullwood, N. J.; Heys, K. A.; Hughes, C.; Lasch, P.; Martin-Hirsch, P. L.; Obinaju, B.; Sockalingum, G. D.; Sule-Suso, J.; Strong, R. J.; Walsh, M. J.; Wood, B. R.; Gardner, P.; Martin, F. L., Using Fourier Transform IR Spectroscopy to Analyze Biological Materials. Nature Protocols 2014, 9, (8), 1771-1791, DOI: 10.1038/nprot.2014.110.

  • 2013
    • Abouimrane, A.; Odom, S. A.; Tavassol, H.; Schulmerich, M. V.; Wu, H. M.; Bhargava, R.; Gewirth, A. A.; Moore, J. S.; Amine, K., 3-Hexylthiophene as a Stabilizing Additive for High Voltage Cathodes in Lithium-Ion Batteries. Journal of the Electrochemical Society 2013, 160, (2), A268-A271, DOI: 10.1149/2.039302jes.

    • Kodali, A. K.; Schulmerich, M.; Palekar, R.; Bhargava, R., Sculpting the Analytical Volume in and around Nanoparticle Sensors Using a Multilayer Geometry. Analytical Chemistry 2013, 85, (8), 3842-3848.

    • Kwon, B.; Jiang, J.; Schulmerich, M. V.; Xu, Z. D.; Bhargava, R.; Liu, G. L.; King, W. P., Bimaterial Microcantilevers with Black Silicon Nanocone Arrays. Sensors and Actuators A-Physical 2013, 199, 143-148, DOI: 10.1016/j.sna.2013.05.007.

    • Kwon, B.; Schulmerich, M. V.; Bhargava, R.; King, W. P., Infrared Emission from Heated Microcantilevers. Nanoscale and Microscale Thermophysical Engineering 2013, 17, (2), 141-153, DOI: 10.1080/15567265.2012.760693.

    • Kwon, B.; Seong, M.; Liu, J. N.; Rosenberger, M. R.; Schulmerich, M. V.; Bhargava, R.; Cunningham, B. T.; King, W. P., Large Infrared Absorptance of Bimaterial Microcantilevers Based on Silicon High Contrast Grating. Journal of Applied Physics 2013, 114, (15), DOI: 10.1063/1.4825313.

    • Liu, Y. Y.; Zhang, C. Y.; Hu, D. H.; Kuhlenschmidt, M. S.; Kuhlenschmidt, T. B.; Mylon, S. E.; Kong, R.; Bhargava, R.; Nguyen, T. H., Role of Collector Alternating Charged Patches on Transport of Cryptosporidium Parvum Oocysts in a Patchwise Charged Heterogeneous Micromodel. Environmental Science & Technology 2013, 47, (6), 2670-2678.

    • Mayerich, D.; Walsh, M.; Schulmerich, M.; Bhargava, R., Real-Time Interactive Data Mining for Chemical Imaging Information: Application to Automated Histopathology. BMC Bioinformatics 2013, 14, DOI: 10.1186/1471-2105-14-156.

    • Moreno-Torres, J. G.; Llora, X.; Goldberg, D. E.; Bhargava, R., Repairing Fractures between Data Using Genetic Programming-Based Feature Extraction: A Case Study in Cancer Diagnosis. Information Sciences 2013, 222, 805-823.

    • Reddy, R. K.; Walsh, M. J.; Schulmerich, M. V.; Carney, P. S.; Bhargava, R., High-Definition Infrared Spectroscopic Imaging. Applied Spectroscopy 2013, 67, (1), 86-92.

    • Shah, A. B.; Sivapalan, S. T.; DeVetter, B. M.; Yang, T. K.; Wen, J. G.; Bhargava, R.; Murphy, C. J.; Zuo, J. M., High-Index Facets in Gold Nanocrystals Elucidated by Coherent Electron Diffraction. Nano Letters 2013, 13, (4), 1840-1846.

    • Sivapalan, S. T.; DeVetter, B. M.; Yang, T. K.; Schulmerich, M. V.; Bhargava, R.; Murphy, C. J., Surface-Enhanced Raman Spectroscopy of Polyelectrolyte-Wrapped Gold Nanoparticles in Colloidal Suspension. Journal of Physical Chemistry C 2013, 117, (20), 10677-10682, DOI: 10.1021/jp402392y.

    • Sivapalan, S. T.; DeVetter, B. M.; Yang, T. K.; van Dijk, T.; Schulmerich, M. V.; Carney, P. S.; Bhargava, R.; Murphy, C. J., Off-Resonance Surface-Enhanced Raman Spectroscopy from Gold Nanorod Suspensions as a Function of Aspect Ratio: Not What We Thought. ACS Nano 2013, 7, (3), 2099-2105.

    • van Dijk, T.; Mayerich, D.; Bhargava, R.; Carney, P. S., Rapid Spectral-Domain Localization. Optics Express 2013, 21, (10), 12822-12830, DOI: 10.1364/oe.21.012822.

    • van Dijk, T.; Mayerich, D.; Carney, P. S.; Bhargava, R., Recovery of Absorption Spectra from Fourier Transform Infrared (FT-IR) Microspectroscopic Measurements of Intact Spheres. Applied Spectroscopy 2013, 67, (5), 546-552, DOI: 10.1366/12-06847.

    • van Dijk, T.; Sivapalan, S. T.; DeVetter, B. M.; Yang, T. K.; Schulmerich, M. V.; Murphy, C. J.; Bhargava, R.; Carney, P. S., Competition between Extinction and Enhancement in Surface-Enhanced Raman Spectroscopy. Journal of Physical Chemistry Letters 2013, 4, (7), 1193-1196.

    • Yeh, K.; Schulmerich, M.; Bhargava, R., Mid-Infrared Microspectroscopic Imaging with a Quantum Cascade Laser. Next-Generation Spectroscopic Technologies VI 2013, 8726, DOI: 10.1117/12.2015984.

  • 2012
    • Bhargava, R., Resolution in Mid-Infrared Imaging: The Theory. Spectroscopy 2012, 27, (2), 74-74.

    • Kwak, J. T.; Reddy, R.; Sinha, S.; Bhargava, R., Analysis of Variance in Spectroscopic Imaging Data from Human Tissues. Analytical Chemistry 2012, 84, (2), 1063-1069.

    • Kwon, B.; Rosenberger, M.; Bhargava, R.; Cahill, D. G.; King, W. P., Dynamic Thermomechanical Response of Bimaterial Microcantilevers to Periodic Heating by Infrared Radiation. Review of Scientific Instruments 2012, 83, DOI: 10.1063/1.3680107.

    • Kwon, B.; Schulmerich, M. V.; Elgass, L. J.; Kong, R.; Holton, S. E.; Bhargava, R.; King, W. P., Infrared Microspectroscopy Combined with Conventional Atomic Force Microscopy. Ultramicroscopy 2012, 116, 56-61.

    • Mahr, D. M.; Bhargava, R.; Insana, M. F., Three-Dimensional in Silico Breast Phantoms for Multimodal Image Simulations. IEEE Transactions on Medical Imaging 2012, 31, (3), 689-697.

    • Walsh, M. J.; Kajdacsy-Balla, A.; Bhargava, R., Mid-Infrared Spectroscopic Imaging for Tissue Histopathology. Laboratory Investigation 2012, 92, 518A-518A.

    • Ambekar, R.; Lau, T. Y.; Walsh, M.; Bhargava, R.; Toussaint, K. C., Quantifying Collagen Structure in Breast Biopsies Using Second-Harmonic Generation Imaging. Biomedical Optics Express 2012, 3, (9), 2021-2035.

    • Bhargava, R., Infrared Spectroscopic Imaging: The Next Generation. Applied Spectroscopy 2012, 66, (10), 1091-1120.

    • Kole, M. R.; Reddy, R. K.; Schulmerich, M. V.; Gelber, M. K.; Bhargava, R., Discrete Frequency Infrared Microspectroscopy and Imaging with a Tunable Quantum Cascade Laser. Analytical Chemistry 2012, 84, (23), 10366-10372.

    • Lu, N. X.; Mylon, S. E.; Kong, R.; Bhargava, R.; Zilles, J. L.; Nguyen, T. H., Interactions between Dissolved Natural Organic Matter and Adsorbed DNA and Their Effect on Natural Transformation of Azotobacter Vinelandii. Science of the Total Environment 2012, 426, 430-435.

    • Odom, S. A.; Tyler, T. P.; Caruso, M. M.; Ritchey, J. A.; Schulmerich, M. V.; Robinson, S. J.; Bhargava, R.; Sottos, N. R.; White, S. R.; Hersam, M. C.; Moore, J. S., Autonomic Restoration of Electrical Conductivity Using Polymer-Stabilized Carbon Nanotube and Graphene Microcapsules. Applied Physics Letters 2012, 101, (4).

    • Schulmerich, M. V.; Walsh, M. J.; Gelber, M. K.; Kong, R.; Kole, M. R.; Harrison, S. K.; McKinney, J.; Thompson, D.; Kull, L. S.; Bhargava, R., Protein and Oil Composition Predictions of Single Soybeans by Transmission Raman Spectroscopy. Journal of Agricultural and Food Chemistry 2012, 60, (33), 8097-8102.

    • Walsh, M. J.; Reddy, R. K.; Bhargava, R., Label-Free Biomedical Imaging with Mid-IR Spectroscopy. IEEE Journal of Selected Topics in Quantum Electronics 2012, 18, (4), 1502-1513.

  • 2011
    • Walsh, M. J.; Mayerich, D. M.; Wiley, E. L.; Kajdacsy-Balla, A.; Bhargava, R., Mid-Infrared Spectroscopic Imaging for Breast Tissue Histopathology: Towards 'Stainless Staining'. Modern Pathology 2011, 24, 1941.

    • Yao, J. M.; Le, A. P.; Schulmerich, M. V.; Maria, J.; Lee, T. W.; Gray, S. K.; Bhargava, R.; Rogers, J. A.; Nuzzo, R. G., Soft Embossing of Nanoscale Optical and Plasmonic Structures in Glass. ACS Nano 2011, 5, (7), 5763-5774.

    • Yao, J. M.; Le, A. P.; Schulmerich, M. V.; Maria, J.; Lee, T. W.; Gray, S. K.; Bhargava, R.; Rogers, J. A.; Nuzzo, R. G., Soft Embossing of Nanoscale Optical and Plasmonic Structures in Glass. Acs Nano 2011, 5, (7), 5763-5774.

    • Liu, J. N.; Schulmerich, M. V.; Bhargava, R.; Cunningham, B. T., Optimally Designed Narrowband Guided-Mode Resonance Reflectance Filters for Mid-Infrared Spectroscopy. Optics Express 2011, 19, (24), 24182-24197.

    • Chanda, D.; Shigeta, K.; Truong, T.; Lui, E.; Mihi, A.; Schulmerich, M.; Braun, P. V.; Bhargava, R.; Rogers, J. A., Coupling of Plasmonic and Optical Cavity Modes in Quasi-Three-Dimensional Plasmonic Crystals. Nature Communications 2011, 2, DOI: 10.1038/ncomms1487.

    • Holton, S. E.; Walsh, M. J.; Bhargava, R., Subcellular Localization of Early Biochemical Transformations in Cancer-Activated Fibroblasts Using Infrared Spectroscopic Imaging. Analyst 2011, 136, (14), 2953-2958.

    • Kodali, A. K.; Bhargava, R., Effect of Non-Specificity in Shape, Size, and Dielectric Properties on Electromagnetic Extinction and Optical Field Enhancement from Spherical Nanolayered Metal-Dielectric Particles. Theoretical Chemistry Accounts 2011, 130, (4-6), 991-1000.

    • Kong, R.; Bhargava, R., Characterization of porcine skin as a model for human skin studies using infrared spectroscopic imaging. Analyst 2011, 136, (11), 2359-2366.

    • Kwak, J. T.; Hewitt, S. M.; Sinha, S.; Bhargava, R., Multimodal microscopy for automated histologic analysis of prostate cancer. BMC Cancer 2011, 11.

    • Nasse, M. J.; Walsh, M. J.; Mattson, E. C.; Reininger, R.; Kajdacsy-Balla, A.; Macias, V.; Bhargava, R.; Hirschmugl, C. J., High-resolution Fourier-transform infrared chemical imaging with multiple synchrotron beams. Nature Methods 2011, 8, (5), 413-416.

    • Kwon, B.; Wang, C.; Park, K.; Bhargava, R.; King, W. P., Thermomechanical Sensitivity of Microcantilevers in the Mid-Infrared Spectral Region. Nanoscale and Microscale Thermophysical Engineering 2011, 15, (1), 16-27.

    • Davis, B. J.; Carney, P. S.; Bhargava, R., Theory of Infrared Microspectroscopy for Intact Fibers. Analytical Chemistry 2011, 83, (2), 525-532.

  • 2010
    • Kodali, A. K.; Llora, X.; Bhargava, R., Optimally designed nanolayered metal-dielectric particles as probes for massively multiplexed and ultrasensitive molecular assays. Proceedings of the National Academy of Sciences of the United States of America 2010, 107, (31), 13620-13625.

    • Kodali, A. K.; Schulmerich, M.; Ip, J.; Yen, G.; Cunningham, B. T.; Bhargava, R., Narrowband Midinfrared Reflectance Filters Using Guided Mode Resonance. Analytical Chemistry 2010, 82, (13), 5697-5706.

    • Kodali, A. K.; Schulmerich, M. V.; Palekar, R.; Llora, X.; Bhargava, R., Optimized nanospherical layered alternating metal-dielectric probes for optical sensing. Optics Express 2010, 18, (22), 23302-23313.

    • Davis, B. J.; Carney, P. S.; Bhargava, R., Theory of Midinfrared Absorption Microspectroscopy: I. Homogeneous Samples. Analytical Chemistry 2010, 82, (9), 3474-3486.

    • Davis, B. J.; Carney, P. S.; Bhargava, R., Theory of Mid-infrared Absorption Microspectroscopy: II. Heterogeneous Samples. Analytical Chemistry 2010, 82, (9), 3487-3499.

    • Kong, R.; Reddy, R. K.; Bhargava, R., Characterization of Tumor Progression in Engineered Tissue using Infrared Spectroscopic Imaging. Analyst 2010, 135, 1569 - 1578.

    • Reddy, R. K.; Bhargava, R., Accurate histopathology from low signal-to-noise ratio spectroscopic imaging data. Analyst 2010, 135, (11), 2818-2825.

    • Schulmerich, M. V.; Reddy, R.; Kodali, A. K.; Elgass, L. J.; Tangella, K.; Bhargava, R., Dark Field Raman Microscopy. Analytical Chemistry 2010, 82, (14), 6273-6280.

  • 2009
    • Llora, X.; Priya, A.; Bhargava , R., Observer-Invariant Histopathology using Genetics-Based Machine Learning. Natural Computing 2009, 8, 101-120.

    • Bhargava, R., Special Issue: Prominent Young Vibrational Spectroscopists 2009 Preface. Vibrational Spectroscopy 2009, 50, (1), 1-1.

    • Bhargava, R.; Perlman, R. S.; Fernandez, D. C.; Levin , I. W.; Bartick, E. G., Non-invasive detection of superimposed latent fingerprints and inter-ridge trace evidence by infrared spectroscopic imaging. Analytical and Bioanalytical Chemistry 2009, 394, (8), 2069-2075.

  • 2008
    • Park, K.; Lee, J.; Bhargava, R.; King, W. P., Routine femtogram-level chemical analyses using vibrational spectroscopy and self-cleaning scanning probe microscopy tips. Analytical Chemistry 2008, 80, (9), 3221-3228.

  • 2007
    • Srinivasan, G.; Bhargava, R., Fourier transform-infrared spectroscopic imaging: The emerging evolution from a microscopy tool to a cancer imaging modality. Spectroscopy 2007, 22, (7), 30-31.

    • Bhargava, R.; Hewitt, S. M.; Levin, I. W. Re:Unrealistic expectations for IR microspectroscopic imaging. Nature Biotechnology 2007, 25, 31-33.

    • Bhargava, R., Towards a practical fourier transform infrared chemical imaging protocol for cancer histopathology. Analytical and Bioanalytical Chemistry 2007, 389, (4), 1155-1169.

  • 2006
    • Bhargava, R.; Fernandez, D. C.; Hewitt, S. M.; Levin, I. W. High throughput assessment of cells and tissues: Bayesian classification of spectral metrics from infrared vibrational spectroscopic imaging data. Biochimica Et Biophysica Acta-Biomembranes 2006, 1758, (7), 830-845.

  • 2005
    • Fernandez, D. C.; Bhargava, R.; Hewitt, S. M.; Levin, I. W. Infrared Spectroscopic Imaging for Observer-invariant Histopathology. Nature Biotechnology 2005, 23, 469-474.

    • Levin, I. W., Bhargava, R. Fourier Transform Infrared Vibrational Spectroscopic Imaging: Integration of Microscopy and Molecular Recognition. Annu. Rev. Phys. Chem. 2005, 56, 429-474.

  • 2004
    • Bhargava, R., Levin, I. W. (2004), "Probing the Structure and Dynamics of Macromolecular Composites by Infrared Spectroscopy and Imaging," Vibrational Spectroscopy, 34, 13-24.

  • 2003
    • Bhargava, R., Wang, S. Q., Koenig, J. L. (2003), "FTIR Microspectroscopy of Polymeric Systems," Advances in Polymer Science, 163, 137-191.

    • Bhargava, R., Levin, I. W. (2003), "Non-invasive Imaging of Molecular Dynamics in Heterogeneous Materials" Macromolecules, 36, 92-96.

  • 2001
    • Bhargava, R., Levin, I. W. (2001), "FTIR imaging: Theory and Practice," Analytical Chemistry, 73, 5157-5167.


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