Hyun Joon Kong


  • Title: Professor
  • Group: Neurotechnology for Memory and Cognition
  • Status: Beckman Part-time Faculty
  • Home: Chemical and Biomolecular Engineering


  • 2057 Beckman Institute
  • 405 North Mathews Avenue
  • Urbana, Illinois 61801


LAS Centennial Scholar, 2013-2016


The overall goal of our lab is to develop advanced material systems for fundamental and applied biosciences. Specially, we focus on tailoring nano- and micro-structures of materials inspired by nature via simple but novel methods and further modulating their chemical and physical properties for multiple applications including drug delivery, diagnosis/bioimaging, 3D cell culture and therapies, and tissue repair and regeneration.


  • 2016
    • Schmidt, J; Lee, M.K.; Ko, E.; Jeong, J.H.; DiPietro, L.; Kong, H. Alginate Sulfates Mitigates Binding Kinetics of Proangiogenic Growth Factors with Receptors towards Revascularization. Molecular Pharmaceutics (In press, 2016).
    • Lee, M., Park, J., Wang, X., Roein-Peikar M., Ko, E., Qin, E., Lee, J., Ha, T.J., Kong, H.J. Rupture force of cell adhesion ligand tethers modulates biological activities of a cell-laden hydrogel. Chemical Communication (In press, 2016).
    • Raman, R., Bhaduri, B., Lee, M.K., Shkumatov, A., Mir, M., Popescu3, G., Kong3, H.J., & Bashir4, R. Projection micro-stereolithography for high-resolution patterning of microvasculature. Advanced Healthcare Materials 5: 622 (2016).
    • Raman, R., Clay, N, Sen, S., Melhem, M., Qin, E., Kong3, H. & Bashir4, R. 3D Printing Enables Separation of Orthogonal Functions Within a Hydrogel Particle. Biomedical Devices (In press, 2016).
  • 2015
    • Lee, M. K.; Rich, M. H.; Shkumatov, A.; Jeong, J. H.; Boppart3, M. D.; Bashir4, R.; Gillette1, M. U.; Lee, J.; Kong3, H., Glacier Moraine Formation-Mimicking Colloidal Particle Assembly in Microchanneled, Bioactive Hydrogel for Guided Vascular Network Construction. Advanced Healthcare Materials 2015, 4, (2), 195-201, DOI:10.1002/adhm.201400153.
    • Rich, M., Lee, M.K., Marshall, N., Clay, N., Chen, J., Mahmassani, Z., Boppart3, M., Kong3, H.J. Water-Hydrogel Binding Affinity Modulates Freeze-Drying Induced Micropore Architecture and Skeletal Myotube Formation. Biomacromolecules 16:2255-2264 (2015).
    • Chen, J., Clay, N.E., Park, N.-h., Kong, H. Non-Spherical Particles for Targeted Drug Delivery. Chemical Engineering Science 125, 20-24 (2015).
    • Shkumatov, A., Thompson, M., Choi, K.M., Sicard, D., Baek, K., Kim, D.H., Tschumperlin, D.J., Prakash, Y.S., Kong, H.J. Matrix stiffness-modulated proliferation and secretory function of the airway smooth muscle cells. American Journal of Physiology: Lung Cellular Molecular Physiology 308:L1125-1135 (2015).
    • Lai, M-H., Clay, N., Kim, D. H., Kong, H.J. Bacterium-Mimicking nanoparticle surface functionalization with targeting motifs. Nanoscale 7: 6737-6744 (2015).
    • Lee, M.K., Rich, M.H., Baek, K., Lee, J., Kong, H. Bioinspired tuning of hydrogel permeabilityrigidity dependency for 3D cell culture. Scientific Reports (Nature) 5: 8948 (2015).
    • Lee, M.K., Rich, M., Lee, J.H., & Kong, H.J. A bio-inspired, microchanneled hydrogel with controlled spacing of cell adhesion ligands regulates 3D spatial organization of cells and tissue. Biomaterials, 58:26-34 (2015).
    • Cha, C., Jeong, J.H., & Kong, H.J. Poly (ethylene glycol)-Poly (lactic-co-glycolic acid) Core-Shell Microspheres with Enhanced Controllability of Drug Encapsulation and Release Rate. Journal of Biomaterials Science, Polymer Edition. 26: 828-840 (2015).
    • Baek, K., Liang, J., Lim, W.T., Zhao, H., Kim, D.H., & Kong, H.J. In Situ Assembly of Anti- Fouling/Bacterial Silver Nanoparticle-Hydrogel Composites with Controlled Particle Release and Matrix Softening. ACS Applied Materials & Interfaces, 7:15359–15367 (2015).
    • Baek, K., Clay, N.E., Qin, E., Sullivan, K., & Kong, H.J. In situ assembly of the collagenpolyacrylamide interpenetrating network hydrogel: Enabling decoupled control of stiffness and degree of swelling. European Polymer Journal (Invited). 72:413-422 (2015).
    • Smith, C.E., Ernenwein, D., Shkumatov, A., Clay, N., Lee, J., Melhem, M., Misra, S., Zimmerman, S.C. & Kong, H.J. Hydrophilic Packaging of Iron Oxide Nanoclusters for Highly Sensitive Imaging. Biomaterials 69: 184-190 (2015).
    • Pan, Y.T., Smith, C.E., Kwok, K.S., Chen, J., Kong, H.J., Yang, H. Functionalized Ultrathin Palladium Nanosheets as Patches for HepG2 Cancer Cells. Chemical Communication 51:1471-1474 (2015).
    • Chen, J., Lee, M.K., Qin, E., Misra, S., & Kong, H.J. Van der Waals force-induced loading of proangiogenic nanoparticles on microbubbles for enhanced neovascularization. Nanoscale 7: 17139- 17147 (2015).
  • 2014
    • Kong, H.J. & Wong, J.Y. Materials for biological modulation, sensing, and imaging. MRS Bulletin, 39: 12-14 (2014).
    • Smith, C. & Kong, H.J. Cross-linkable liposomes stabilize a magnetic resonance contrast-enhancing polymeric fastener. Langmuir 30, 3697 (2014).
    • Shkumatov, A., Baek, K., & Kong, H.J. Matrix Rigidity-Modulated Cardiovascular Organoid Formation from Embryoid Bodies. PLoS ONE 9(4): e94764. (2014)
    • Lai, M.H., Lee, S., Smith, C.E., Kim, K. & Kong, H.J. Tailoring Polymersome Bilayer Permeability Improves Enhanced Permeability and Retention Effect for Bioimaging. ACS Appl. Mater. Interfaces 6, 10821-10829 (2014).
    • Yang, T., Huh, W., Kong, H.J., Jho, J.Y. & Kim, I.W. Effects of polymer architecture and charge density on the pH-responsive Ca (II) release from brushite. Colloids and Surfaces A. 459:74-81 (2014).
    • Brahmbhatt A, NievesTorres E, Yang B, Edwards WD, Roy Chaudhury P, Lee MK, Kong H.J., Mukhopadhyay D, Kumar R, Misra S. The role of iex-1 in the pathogenesis of venous neointimal hyperplasia associated with hemodialysis arteriovenous fistula. PLoS One. 18;9(7):e102542 (2014).
    • Vega L., J.C.M., Lee, M.K., Jeong, J.H., Smith, C.E., Lee, K.Y., Chung, H.J., Leckband, D.E. & Kong3, H.J. Recapitulating cell-cell adhesion using N-Cadherin biologically tethered to substrates. Biomacromolecules 15(6), 2172–2179 (2014)
    • Rich, M.H., Lee, M.K., Baek, K., Jeong, J.H., Kim, D.H., Millet, L.J., Bashir4, R., Kong3, H. Material-mediated proangiogenic factor release pattern modulates quality of regenerated blood vessels. Journal of Controlled Release 196: 363-369 (2014).
  • 2013
    • Schmidt, J., Jeong, J.H., Chan, V., Cha, C., Baek, K., Lai, M-H, Bashir4, R., Kong3, H.J. Tailoring the Dependency between Rigidity and Water Uptake of a Microfabricated Hydrogel with the Conformational Rigidity of a Polymer Cross-linker. Biomacromolecules 14, 1361 (2013).
    • Jeong, J.H., Liang, Y., Jang, M., Cha, C., Chu, C., Lee, H., Jung, W.G., Kim, J.W., Boppart3, S.A., & Kong3, H.J. Stiffness-modulated water retention and neovascularization of dermal fibroblastencapsulating collagen gel. Tissue Engineering 19, 1275 (2013).
    • Cha, C., Antoniadou, E., Lee, M., Jeong, J., Ahmed, W.W., Saif1, T.A., Boppart3, S.A. & Kong3, H.J. Tailoring Hydrogel Adhesion to Polydimethylsiloxane Substrates Using Polysaccharide Glue. Angewandte Chemie 125, 7087 (2013).
    • Damhorst, G.L., Smith, C.E., Salm, E.M., Sobieraj, M.M., Mi, H., Kong3, H.J. & Bashir4 R. A liposome-based ion release impedance sensor for biological detection. Biomedical Devices 15, 895 (2013).
    • Baek, K.H., Jeong, J., Shkumatov, A., Bashir4, R. & Kong3, H.J. In situ self-folding assembly of multi-walled hydrogel tube for uniaxial, sustained molecular release. Advanced Materials 25, 5568 (2013).
    • Jeong JH, Schmidt JJ, Kohman RE, Zill AT, Devolder RJ, Smith CE, Lai MH, Shkumatov A, Jensen TW, Schook LG, Zimmerman SC, Kong H.J. Leukocyte-Mimicking Stem Cell Delivery via in Situ Coating of Cells with a Bioactive Hyperbranched Polyglycerol. Journal of the American Chemical Society 135, 8770 (2013).
    • Janardhana, R., Yang, B., Vohra, P., Roy, B., Withers, S., Bhattacharya, S., Mandrekar, J., Kong, H.J., Leof, E.B., Mukopadyyay, D., & Misra, S., Simvastatin reduces venous stenosis formation in a murine hemodialysis vascular access model. Kidney International 84, 338 (2013).
    • Yonet, N., M. Rich, Lee, M.K., Lai, M-H, & Kong, H.J. Spatiotemporal Control of Erosion and Molecular Release from Micropatterned Poly(ethylene glycol)-based Hydrogel. Biomaterials 34, 8416 (2013).
    • DeVolder, R., Antoniadou, E. & Kong, H.J. Enzymatically cross-linked injectable alginate-g-pyrrole hydrogels for neovascularization. Journal of Controlled Release 172, 30 (2013).
    • Clay, N., Baek, K.H., Shkumatov, A., Lai, M.-H., Smith, C.E., Rich, M. & Kong, H.J. Flow- Mediated Stem Cell Labeling with Superparamagnetic Iron Oxide Nanoparticle Clusters. ACS Appl. Mater. Interfaces 5, 10266 (2013).
    • Smith, C.E., Shkumatov, A., Withers, S. G., Yang, B., Glockner, J. F., Misra, S., Roy, E. J., Wong, C.-H., Zimmerman, S. C. & Kong, H.J. A Polymeric Fastener Can Easily Functionalize Liposome Surfaces with Gadolinium for Enhanced Magnetic Resonance Imaging. ACS Nano 7, 9599 (2013).
    • Liang, Y., Kong, H.J. & Tong, Y.W. Generation of Cell-Instructive Collagen Gels through Thermodynamic Control. ACS Macro Letters 2, 1077 (2013).
  • 2012
    • C. Cha, S.R. Kim, Y.S. Jin, H.J. Kong, Tuning structural durability of yeast-encapsulating alginate gel beads with interpenetrating networks for sustained bioethanol production. Biotechnology & Bioengineering, 109, 63-73 (2012).
    • Jeong, J., Cha, C., Kaczamarowki, A., Oh, S., Kong, H.J. Polyaspartamide Vesicles Induced by Metallic Nanoparticles. Soft Matter, 8, 2237-2242 (2012)
    • An, E., Jeong, C.B., Cha, C., Kim, D.H., Lee, H., Kong, H.J., Kim, J., Kim, J.W. Fabrication of microgel-in-liposome particles with improved water retention. Langmuir 28, 4095 (2012).
    • Chu, C. & Kong, H.J. Interplay of Cell Adhesion Matrix Stiffness and Cell Type for Non-Viral Gene Delivery. Acta Biomaterialia 8, 2612 (2012).
    • Lai, M., Jeong, J., DeVolder, R., Brockman, C., Schroeder, C.M., Kong, H.J. Ellipsoidal polyaspartamide polymersomes with enhanced cell-targeting ability. Advanced Functional Materials 22, 3239 (2012)
    • DeVolder, R., Kim, E.S., Kim, I.W. & Kong, H.J. Modulating the rigidity and mineralization of collagen gels using poly(lactic-co-glycolic acid) microparticles. Tissue Engineering 18, 1642 (2012).
    • DeVolder, R., Kong, H.J. Hydrogels for in vivo-like three-dimensional cellular studies. Wiley Interdisciplinary Reviews: Systems Biology and Medicine 4, 351 (2012).
    • DeVolder, R., Andrew, T.Z., Jeong, J.H., Kong, H.J. Microfabrication of proangiogenic cell-laden alginate-g-Pyrrole hydrogels. Biomaterials 33, 7718 (2012)
    • Cho, E. C., Kong, H.J., Oh, T., Cho, K., Protein adhesion regulated by nanoscale surface conformation. Soft Matter 8: 11801-11808 (2012).
    • C. Cha, J.H. Jeong, X. Tang, A. Zill, S.C. Zimmerman, Y. Prakash, T. Saif1, H.J. Kong3, “Top-down synthesis of versatile polyaspartamide linkers for single-step protein conjugation to materials” Bioconjugate Chemistry , 22, 2377-2383 (2012).
    • V. Chan, J.H. Jeong, P. Bajaj, M. Collens, T. Saif1, H.J. Kong3, R. Bashir4, “Multi-Material Bio- Fabrication of Hydrogel Cantilevers and Actuators with Stereolithography” Lab on a Chip, 12, 88- 98 (2012).
    • J. H. Jeong, V. Chan, C. Cha, P. Zortuluna, C. Dyck, K. Jimmy Hsia, R. Bashir4, H. J. Kong3, ’Living’ Microvascular Stamp for Patterning of Functional Neovessels; Orchestrated Control of Matrix Property and Geometry. Advanced Materials 23, 3139-3143 (2012).
    • Zhao, Y., Graf, B., Chaney, E., Mahmassani, Z., Antoniadou, E., DeVolder, R., Kong3, H.J., Boppart3, M., & Boppart3, S. Integrated multimodal optical microscopy for structural and functional imaging of engineered and natural skin. Journal of Biophotonics 5, 437 (2012)
    • Larry, J.M., Elise, A.C., Robert, F. Kidong, P., Kong3, H.J., King4, W.P., Bashir4, R. Characterization of Mass and Swelling of Hydrogel Microstructures using MEMS Resonant Mass Sensor Arrays. Small 8, 2555 (2012).
    • V. Chan, M.B. Collens, J.H. Jeong, H.J. Kong3, R. Bashir4, Directed cell growth and alignment on protein-patterned 3D hydrogels with stereolithography. Virtual and Physical Prototyping (2012)
    • Chan, V., Park, K., Collens, M., Kong3, H.J., Saif1, T., & Bashir4, R., Development of miniaturized walking biological machines. Scientific Reports (2012).


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