- Title: Professor
- Group: Nanoelectronics and Nanomaterials
- Status: Beckman Affiliate Faculty
- Home: Physics
Alexey Bezryadin recieved his PH.D. from the Joseph Fourier University and Low-Temperature Research Center (CRTBT-CNRS), Grenoble, France in 1995. He is currently an assistant Professor in the Illinois Department of Physics and an affiliate faculty member in the Beckman Institute Nanoelectronics and Nanomaterials group. He is also a Research Assistant Professor at the Illinois Micro and Nanotechnology Laboratory.
Center for Advanced Study Fellow (2004); Xerox Junior Faculty Research Award (2004); National Science Foundation CAREER Award (2002); Alfred P. Sloan Foundation Fellowship (2002); Citation for outstanding Ph.D. thesis work ("Avec Mention et Félicitations du Jury") Joseph Fourier University, Grenoble, France (1995).
The main goal of the reseach is to apply biological machines as tools to achieve high-resolution, high-rate imaging on the molecular level. Several proof-of-principle studies have been reported that interfaced molecular motors with nanoscale man-made objects, but the dream of using Nature's own nanomachines for practical applications has yet to be realized. Thus, molecular motors remain interesting structures that stir the imagination but which have not been used to create practically important functional devices.
We aim to make this important step by combining nanofabrication, kinesin-mediated microtubule transport, microfluidics, and optical single-molecule detection. It is expected that a resolution of ~50 nm or less can be achieved, on single molecules or segments of DNA molecules, using near-field optical slit microscopy. A molecular motor, based on a microtubule-kinesin interaction, will perform this task. If successful, this approach will enable rapid DNA mapping and possibly single-nucleotide polymorphism identification with ~10 times higher spatial resolution at the single-DNA-molecule level in a massively parallel way. Also, if successful, this method will probably be the first practical application of molecular motors, which have attracted much attention recently but so far have not provided many practical solutions to important technological problems.
Rogachev, A.; Bollinger, A.T.; Bezryadin, A. Influence of high magnetic fields on the superconducting transition of one-dimensional Nb and MoGe nanowires. Physical Review Letters 2005, 94, 017004.
Re-meika, M. and Bezryadin, A. Electron-beam-induced crystallization and nanostructuring of suspended metallic nanowires. Nanotechnology 2005, 16, 1172-1176.
Hopkins, D.; Pekker, D.; Goldbart, P.; Bezryadin, A. Superconducting phase gradiometer made using DNA molecular templates. Science 2005, 308, 1762.
Coskun, U.C.; Wei, T.C.; Visveshwara, S.; Goldbart, P.; Bezryadin, A. h/e Magnetic Flux Modulation of the Energy Gap in Nanotube Quantum Dots. Science 2004, 304, 1132.
Porath, D., Bezryadin, A., de Vries, S., and Dekker, C. (2000), "Direct measurements of electrical transport through DNA molecules," Nature, 403, pp. 635-638.
Bezryadin, A., Lau, C.N., and Tinkham, M. (2000), "Quantum suppression of superconductivity in ultrathin nanowires," Nature, 404, pp. 971-974.
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