Stephanie S. Ceman
Primary AffiliationCellular and Molecular Foundations of Intelligent Behavior
I am interested in the molecular basis of cognition, which I study using fragile X syndrome as a model system. Fragile X syndrome (FXS) is caused by the absence of expression of the fragile X mental retardation protein FMRP, which is encoded by the FMR1 gene. FMRP is an RNA binding protein that binds ~4% of brain RNAs and regulates their translation. I am focused on understanding how FMRP regulates translation of its bound RNAs. I collaborate with Roberto Galvez at the Beckman Institute in studying the behavioral and spine phenotype in Fmr1 knockout mice to gain insight into the neuronal deficits underlying FXS. My group has discovered a novel helicase MOV10 that associates with FMRP and facilitates translation regulation of commonly bound RNAs (Kenny et al, Cell Reports 2014). To gain insight into MOV10 function in brain, we are creating a MOV10 knockout mouse. We will characterize the behavior of this mouse by collaborating with Justin Rhodes. One of the great intellectual advantages of my association with the Beckman Institute is my association with the Neuroscience program. This affiliation has greatly enhanced my development as a neuroscientist.
- Kenny, P. J.; Zhou, H. J.; Kim, M.; Skariah, G.; Khetani, R. S.; Drnevich, J.; Arcila, M. L.; Kosik, K. S.; Ceman, S., Mov10 and FMRP Regulate Ago2 Association with Microrna Recognition Elements. Cell Reports 2014, 9, (5), 1729-1741, DOI:10.1016/j.celrep.2014.10.054.
- Blackwell, E.; Ceman, S., Arginine Methylation of RNA-Binding Proteins Regulates Cell Function and Differentiation. Molecular Reproduction and Development 2012, 79, (3), 163-175.
- Kim, M.; Ceman, S., Fragile X Mental Retardation Protein: Past, Present and Future. Current Protein & Peptide Science 2012, 13, (4), 358-371.
- Winograd, C.; Ceman, S., Exploring the Zebra Finch Taeniopygia Guttata as a Novel Animal Model for the Speech-Language Deficit of Fragile X Syndrome, In Modeling Fragile X Syndrome; Denman, R. B., Ed. 2012; Vol. 54, 181-197.
- Blackwell, E.; Ceman, S., A New Regulatory Function of the Region Proximal to the Rgg Box in the Fragile X Mental Retardation Protein. Journal of Cell Science 2011, 124, (18), 3060-3065.
- Ceman, S.; Saugstad, J., MicroRNAs: Meta-controllers of gene expression in synaptic activity emerge as genetic and diagnostic markers of human disease. Pharmacology & Therapeutics 2011, 130, (1), 26-37.
- Blackwell, E.; Zhang, X.; Ceman, S., Arginines of the RGG box regulate FMRP association with polyribosomes and mRNA. Human Molecular Genetics 2010, 19, (7), 1314-1323.
- Cheever, A.; Blackwell, E.; Ceman, S., Fragile X protein family member FXR1P is regulated by microRNAs. Rna-a Publication of the Rna Society 2010, 16, (8), 1530-1539.
- Cheever, A.; Ceman, S., Phosphorylation of FMRP inhibits association with Dicer. RNA-A Publication of the RNA Society 2009, 15, (3), 362-366.
- Cheever, A.; Ceman, S., Translation regulation of mRNAs by the fragile X family of proteins through the microRNA pathway. RNA Biology 2009, 6, (2), 175-178.
- Kim, M.; Bellini, M.; Ceman, S., Fragile X Mental Retardation Protein FMRP Binds mRNAs in the Nucleus. Molecular and Cellular Biology 2009, 29, (1), 214-228.
- Narayanan, U.; Nalavadi, V.; Nakamoto, M.; Thomas, G.; Ceman, S.; Bassell, G. J.; Warren, S. T., S6K1 phosphorylates and regulates fragile X mental retardation protein (FMRP) with the neuronal protein synthesis-dependent mammalian target of rapamycin (mTOR) signaling cascade. Journal of Biological Chemistry 2008, 283, (27), 18478-18482.
- Winograd, C.; Clayton, D.; Ceman, S., Expression of Fragile X Mental Retardation Protein within the Vocal Control System of Developing and Adult Male Zebra Finches. Neuroscience 2008, 157, (1), 132-142.