Elena Romanova's directory photo.

Elena Romanova

Research Assistant Professor

Primary Affiliation

Neurotechnology for Memory and Cognition


Status Research Staff

Home Department of Chemistry

Phone 300-1932


Address 2255 Beckman Institute, 405 North Mathews Avenue

  • Biography

    Elena Romanova is a research assistant professor at the Department of Chemistry. Her primary affiliation is Neurotechnology for Memory and Cognition. After earning her Ph.D, she joined a newly established, NIDA funded, Neuroproteomics & Neurometabolomics Center on Cell-Cell Signaling to lead the development and validation of customized cutting-edge technological solutions for investigation of neurochemical changes in the brain resulted from drug abuse and addiction. Currently, Professor Romanova continues supporting expanded national and international neuroscience communities of the Center by coordinating and overseeing multidisciplinary, collaborative user projects on intricacies of intercellular communication. She joined the faculty of the Department of Chemistry at UIUC as Research Assistant Professor in January 2019.


    • B.S., biology, Belarusian State University

    • Ph.D., chemistry, University of Illinois, 2005

  • Research

    Research areas:

    • Bioanalytical mass spectrometry

    • Proteomics

    • Peptidomics

    Research interests:

    • Development and optimization of sampling

    • Liquid separations

    • Molecule structural characterization

    Overall direction of research is bioanalytical chemistry with emphasis on microanalysis, mass spectrometry and liquid separation techniques for measurement and characterization of biomolecules and/or drugs in nervous and neuroendocrine systems. Specific approaches include but not limited to high throughput peptidomics, direct single cell and tissue chemical profiling by mass spectrometry, differential quantitative assessment of neurochemical changes under pathophysiological conditions or environmental challenges, and mass spectrometry imaging, all with the use of relevant bioinformatics tools. The overarching goal of research is to gain insights into molecular basis of complex physiological responses in various animal models that play critical roles in fundamental or translational research and, respectively, in advancement of human health. 

  • 2022

    • Anapindi, K. D. B., Romanova, E. V., Checco, J. W., & Sweedler, J. V. (2022). Mass Spectrometry Approaches Empowering Neuropeptide Discovery and Therapeutics. Pharmacological Reviews, 74(3), 662-679.
    • Chan-Andersen, P. C., Romanova, E. V., Rubakhin, S. S., & Sweedler, J. V. (2022). Profiling 26,000 Aplysia californica neurons by single cell mass spectrometry reveals neuronal populations with distinct neuropeptide profiles. Journal of Biological Chemistry, 298(8), [102254].
    • De La Toba, E. A., Bell, S. E., Romanova, E. V., & Sweedler, J. V. (2022). Mass Spectrometry Measurements of Neuropeptides: From Identification to Quantitation. Annual Review of Analytical Chemistry, 15, 83-106.
    • Lin, P., Gillard, B. T., Pauža, A. G., Iraizoz, F. A., Ali, M. A., Mecawi, A. S., Alim, F. Z. D., Romanova, E. V., Burger, P. A., Greenwood, M. P., Adem, A., & Murphy, D. (2022). Transcriptomic plasticity of the hypothalamic osmoregulatory control centre of the Arabian dromedary camel. Communications biology, 5(1), [1008].
    • Rubakhin, S. S., Romanova, E. V., & Sweedler, J. V. (2022). High-Throughput Image-Guided Microprobe Mass Spectrometric Analysis of Single Cells. In Neuromethods (pp. 115-163). (Neuromethods; Vol. 184). Humana Press Inc..


    • Romanova, E. V., & Sweedler, J. V. (2015). Peptidomics for the discovery and characterization of neuropeptides and hormones. Trends in Pharmacological Sciences, 36(9), 579-586.
    • Romanova, E. V., Rubakhin, S. S., Ossyra, J. R., Zombeck, J. A., Nosek, M. R., Sweedler, J. V., & Rhodes, J. S. (2015). Differential peptidomics assessment of strain and age differences in mice in response to acute cocaine administration. Journal of Neurochemistry, 135(5), 1038-1048.


    • Romanova, E. V., Aerts, J. T., Croushore, C. A., & Sweedler, J. V. (2014). Small-Volume Analysis of Cell-Cell Signaling Molecules in the Brain. Neuropsychopharmacology, 39(1), 50-64.


    • Romanova, E. V., Dowd, S. E., & Sweedler, J. V. (2013). Quantitation of endogenous peptides using mass spectrometry based methods. Current Opinion in Chemical Biology, 17(5), 801-808.


    • Rubakhin, S. S., Romanova, E. V., Nemes, P., & Sweedler, J. V. (2011). Profiling metabolites and peptides in single cells. Nature Methods, 8(4), S20-S29.


    • Collins, J. J., Hou, X., Romanova, E. V., Lambrus, B. G., Miller, C. M., Saberi, A., Sweedler, J. V., & Newmark, P. A. (2010). Genome-wide analyses reveal a role for peptide hormones in planarian germline development. PLoS biology, 8(10), [e1000509].


    • Romanova, E. V., Rubakhin, S., & Sweedler, J. V. (2008). One-step sampling, extraction, and storage protocol for peptidomics using dihydroxybenzoic acid. Analytical Chemistry, 80(9), 3379-3386.