Hee Jung Chung's directory photo.

Hee Jung Chung

Associate Professor

Primary Affiliation

Neurotechnology for Memory and Cognition


Status Affiliate Faculty

Home Department of Molecular and Integrative Physiology

Phone 244-6839



  • Biography

    Hee Jung Chung is an associate professor in the Department of Molecular and Integrative Physiology. Her research interests include neurological and behavioral disorders.


    • B.S., Cornell University, 1995
    • Ph.D., Johns Hopkins University School of Medicine, 2002
    • Postdoc, University of California, 2002-2009
  • Honors
    • 2014: James E. Heath Award for excellence in teaching in Physiology, University of Illinois 
    • 2013-2014: Targeted Research Initiative for Severe Symptomatic Epilepsies Grant Award, Epilepsy Foundation 
    • 2011-2013: Basil O'Connor Starter Scholar Research Award, March of Dimes Foundation 
    • 2011-2014: Carver Young Investigator Competition Award, Roy J. Carver Charitable Trust 
  • Research

    Research areas:

    • Brain Plasticity

    • Molecular and Cellular Neuroscience

    • Neural Bases of Disease and Disorders

    • Neural Excitability, Synapses, and Glia

    Research interests:

    • Neurological and Behavioral Disorders

    Epilepsy is a common chronic brain disorder that is caused by excessive brain activity clinically characterized as seizures. About 40% of epilepsy is associated with genetic mutations. The cause for the rest of epilepsy is unclear. Since ion channels are critical regulators of neuronal activity, the goals of my research program at the University of Illinois at Urbana Champaign (UIUC) have been to (1) understand how epilepsy mutations affect ion channel function and lead to hyperexcitability in inherited or de novo epilepsy, and (2) identify molecular mechanisms that alter ion channels to cause hyperexcitability in acquired epilepsy.

  • 2024

    • Mind In Vitro Platforms: Versatile, Scalable, Robust, and Open Solutions to Interfacing with Living Neurons Zhang, X., Dou, Z., Kim, S. H., Upadhyay, G., Havert, D., Kang, S., Kazemi, K., Huang, K. Y., Aydin, O., Huang, R., Rahman, S., Ellis-Mohr, A., Noblet, H. A., Lim, K. H., Chung, H. J., Gritton, H. J., Saif, M. T. A., Kong, H. J., Beggs, J. M. and Gazzola, M., Mar 20 2024, In: Advanced Science. 11, 11, 2306826.
    • Neuronal innervation regulates the secretion of neurotrophic myokines and exosomes from skeletal muscle Huang, K.-Y., Upadhyay, G., Ahn, Y., Sakakura, M., Pagan-Diaz, G. J., Cho, Y., Weiss, A. C., Huang, C., Mitchell, J. W., Li, J., Tan, Y., Deng, Y.-H., Ellis-Mohr, A., Dou, Z., Zhang, X., Kang, S., Chen, Q., Sweedler, J. V., Im, S. G. and Bashir, R. and 5 others, , May 7 2024, In: Proceedings of the National Academy of Sciences. 121, 19, e2313590121.


    • Artificial confocal microscopy for deep label-free imaging Chen, X., Kandel, M. E., He, S., Hu, C., Lee, Y. J., Sullivan, K., Tracy, G., Chung, H. J., Kong, H. J., Anastasio, M. and Popescu, G., Mar 2023, In: Nature Photonics. 17, 3, p. 250-258 9 p.
    • Intracerebral Nanoparticle Transport Facilitated by Alzheimer Pathology and Age Tracy, G. C., Huang, K. Y., Hong, Y. T., Ding, S., Noblet, H. A., Lim, K. H., Kim, E. C., Chung, H. J. and Kong, H., Dec 13 2023, In: Nano letters. 23, 23, p. 10971-10982 12 p.
    • Quantitative DNA-PAINT imaging of AMPA receptors in live neurons Youn, Y., Lau, G. W., Lee, Y., Maity, B. K., Gouaux, E., Chung, H. J. and Selvin, P. R., Feb 27 2023, In: Cell Reports Methods. 3, 2, 100408.


    • Heterozygous Deletion of Epilepsy Gene KCNQ2 Has Negligible Effects on Learning and Memory Tracy, G. C., Wilton, A. R., Rhodes, J. S. and Chung, H. J., Jul 19 2022, In: Frontiers in Behavioral Neuroscience. 16, 930216.
    • Homeostatic regulation of extracellular signal-regulated kinase 1/2 activity and axonal Kv7.3 expression by prolonged blockade of hippocampal neuronal activity Baculis, B. C., Kesavan, H., Weiss, A. C., Kim, E. H., Tracy, G. C., Ouyang, W., Tsai, N. P. and Chung, H. J., Jul 28 2022, In: Frontiers in Cellular Neuroscience. 16, 838419.
    • Pharmacological inhibition of STriatal-Enriched protein tyrosine Phosphatase by TC-2153 reduces hippocampal excitability and seizure propensity Walters, J. M., Kim, E. C., Zhang, J., Jeong, H. G., Bajaj, A., Baculis, B. C., Tracy, G. C., Ibrahim, B., Christian-Hinman, C. A., Llano, D. A., Huesmann, G. and Chung, H. J., May 2022, In: Epilepsia. 63, 5, p. 1211-1224 14 p.


    • An epilepsy-causing mutation leads to co-translational misfolding of the Kv7.2 channel Urrutia, J., Aguado, A., Gomis-Perez, C., Muguruza-Montero, A., Ballesteros, O. R., Zhang, J., Nuñez, E., Malo, C., Chung, H. J., Leonardo, A., Bergara, A. and Villarroel, A., Dec 2021, In: BMC biology. 19, 1, 109.
    • Multiscale Assay of Unlabeled Neurite Dynamics Using Phase Imaging with Computational Specificity Kandel, M. E., Kim, E., Lee, Y. J., Tracy, G., Chung, H. J. and Popescu, G., May 28 2021, In: ACS Sensors. 6, 5, p. 1864-1874 11 p.
    • PIP2-dependent coupling of voltage sensor and pore domains in Kv7.2 channel Pant, S., Zhang, J., Kim, E. C., Lam, K., Chung, H. J. and Tajkhorshid, E., Dec 2021, In: Communications biology. 4, 1, 1189.
    • Spontaneous seizure and memory loss in mice expressing an epileptic encephalopathy variant in the calmodulin-binding domain of Kv7.2 Kim, E. C., Zhang, J., Tang, A. Y., Bolton, E. C., Rhodes, J. S., Christian-Hinman, C. A. and Chung, H. J., Dec 21 2021, In: Proceedings of the National Academy of Sciences. 118, 51, e2021265118.


    • A sensitive and specific nanosensor for monitoring extracellular potassium levels in the brain Liu, J., Li, F., Wang, Y., Pan, L., Lin, P., Zhang, B., Zheng, Y., Xu, Y., Liao, H., Ko, G., Fei, F., Xu, C., Du, Y., Shin, K., Kim, D., Jang, S. S., Chung, H. J., Tian, H., Wang, Q. and Guo, W. and 4 others, , Apr 1 2020, In: Nature Nanotechnology. 15, 4, p. 321-330 10 p.
    • Heterozygous loss of epilepsy gene KCNQ2 alters social, repetitive and exploratory behaviors Kim, E. C., Patel, J., Zhang, J., Soh, H., Rhodes, J. S., Tzingounis, A. V. and Chung, H. J., Jan 1 2020, In: Genes, Brain and Behavior. 19, 1, e12599.
    • Identifying mutation hotspots reveals pathogenetic mechanisms of KCNQ2 epileptic encephalopathy Zhang, J., Kim, E. C., Chen, C., Procko, E., Pant, S., Lam, K., Patel, J., Choi, R., Hong, M., Joshi, D., Bolton, E., Tajkhorshid, E. and Chung, H. J., Dec 1 2020, In: Scientific reports. 10, 1, 4756.
    • Optimizing Quantum Dot Probe Size for Single-Receptor Imaging Le, P., Vaidya, R., Smith, L. D., Han, Z., Zahid, M. U., Winter, J., Sarkar, S., Chung, H. J., Perez-Pinera, P., Selvin, P. R. and Smith, A. M., Jul 28 2020, In: ACS Nano. 14, 7, p. 8343-8358 16 p.
    • Polycystin 2 is increased in disease to protect against stress-induced cell death Brill, A. L., Fischer, T. T., Walters, J. M., Marlier, A., Sewanan, L. R., Wilson, P. C., Johnson, E. K., Moeckel, G., Cantley, L. G., Campbell, S. G., Nerbonne, J. M., Chung, H. J., Robert, M. E. and Ehrlich, B. E., Dec 1 2020, In: Scientific reports. 10, 1, 386.
    • The Role of Kv7 Channels in Neural Plasticity and Behavior Baculis, B. C., Zhang, J. and Chung, H. J., Sep 18 2020, In: Frontiers in Physiology. 11, 568667.


    • Counting growth factors in single cells with infrared quantum dots to measure discrete stimulation distributions Le, P., Lim, S. J., Baculis, B. C., Chung, H. J., Kilian, K. and Smith, A. M., Dec 1 2019, In: Nature communications. 10, 1, 909.
    • Reactive oxygen species-responsive drug delivery systems for the treatment of neurodegenerative diseases Ballance, W. C., Qin, E. C., Chung, H. J., Gillette, M. U. and Kong, H., Oct 2019, In: Biomaterials. 217, 119292.


    • Helicobacter pylori Infection Modulates Host Cell Metabolism through VacA-Dependent Inhibition of mTORC1 Kim, I. J., Lee, J., Oh, S. J., Yoon, M. S., Jang, S. S., Holland, R. L., Reno, M. L., Hamad, M. N., Maeda, T., Chung, H. J., Chen, J. and Blanke, S. R., May 9 2018, In: Cell Host and Microbe. 23, 5, p. 583-593.e8
    • Loss of fragile X protein FMRP impairs homeostatic synaptic downscaling through tumor suppressor p53 and ubiquitin E3 ligase Nedd4-2 Lee, K. Y., Jewett, K. A., Chung, H. J. and Tsai, N. P., Aug 15 2018, In: Human molecular genetics. 27, 16, p. 2805-2816 12 p.
    • Reduced axonal surface expression and phosphoinositide sensitivity in Kv7 channels disrupts their function to inhibit neuronal excitability in Kcnq2 epileptic encephalopathy Kim, E. C., Zhang, J., Pang, W., Wang, S., Lee, K. Y., Cavaretta, J. P., Walters, J., Procko, E., Tsai, N. P. and Chung, H. J., Oct 2018, In: Neurobiology of Disease. 118, p. 76-93 18 p.


    • Electroconvulsive seizures in rats and fractionation of their hippocampi to examine seizure-induced changes in postsynaptic density proteins Jang, S. S., Jeong, H. G. and Chung, H. J., Aug 2017, In: Journal of Visualized Experiments. 2017, 126, e56016.
    • Epilepsy-associated gene Nedd4-2 mediates neuronal activity and seizure susceptibility through AMPA receptors Zhu, J., Lee, K. Y., Jewett, K. A., Man, H. Y., Chung, H. J. and Tsai, N. P., Feb 2017, In: PLoS genetics. 13, 2, e1006634.
    • Mdm2 mediates FMRP- and Gp1 mGluR-dependent protein translation and neural network activity Liu, D. C., Seimetz, J., Lee, K. Y., Kalsotra, A., Chung, H. J., Lu, H. and Tsai, N. P., Oct 15 2017, In: Human molecular genetics. 26, 20, p. 3895-3908 14 p.
    • Prolonged seizure activity causes caspase dependent cleavage and dysfunction of G-protein activated inwardly rectifying potassium channels Baculis, B. C., Weiss, A. C., Pang, W., Jeong, H. G., Lee, J. H., Liu, D. C., Tsai, N. P. and Chung, H. J., Dec 1 2017, In: Scientific reports. 7, 1, 12313.


    • Emerging link between Alzheimer's disease and homeostatic synaptic plasticity Jang, S. S. and Chung, H. J., 2016, In: Neural Plasticity. 2016, 7969272.
    • Seizure-Induced Regulations of Amyloid- ß, STEP 61 , and STEP 61 Substrates Involved in Hippocampal Synaptic Plasticity Jang, S. S., Royston, S. E., Lee, G., Wang, S. and Chung, H. J., 2016, In: Neural Plasticity. 2016, 2123748.
    • Three dimensional conjugation of recombinant N-cadherin to a hydrogel for: In vitro anisotropic neural growth Vega, J. C. M. L., Lee, M. K., Qin, E. C., Rich, M., Lee, K. Y., Kim, D. H., Chung, H. J., Leckband, D. E. and Kong, H., 2016, In: Journal of Materials Chemistry B. 4, 42, p. 6803-6811 9 p.


    • N-methyl-D-aspartate receptors mediate activity-dependent down-regulation of potassium channel genes during the expression of homeostatic intrinsic plasticity Lee, K. Y., Royston, S. E., Vest, M. O., Ley, D. J., Lee, S., Bolton, E. C. and Chung, H. J., Dec 2015, In: Molecular Brain. 8, 1, 4.
    • Regulation of STEP61 and tyrosine-phosphorylation of NMDA and AMPA receptors during homeostatic synaptic plasticity Jang, S. S., Royston, S. E., Xu, J., Cavaretta, J. P., Vest, M. O., Lee, K. Y., Lee, S., Jeong, H. G., Lombroso, P. J. and Chung, H. J., Sep 22 2015, In: Molecular Brain. 8, 1, 55.


    • NMDA receptors and L-type voltage-gated Ca2+ channels mediate the expression of bidirectional homeostatic intrinsic plasticity in cultured hippocampal neurons Lee, K. Y. and Chung, H. J., Sep 26 2014, In: Neuroscience. 277, p. 610-623 14 p.
    • Polarized axonal surface expression of neuronal KCNQ potassium channels is regulated by calmodulin interaction with KCNQ2 subunit Cavaretta, J. P., Sherer, K. R., Lee, K. Y., Kim, E. H., Issema, R. S. and Chung, H. J., Jul 31 2014, In: PloS one. 9, 7, e103655.
    • Recapitulating cell-cell adhesion using N-cadherin biologically tethered to substrates Vega L., J. C. M., Lee, M. K., Jeong, J. H., Smith, C. E., Lee, K. Y., Chung, H. J., Leckband, D. E. and Kong, H., Jun 9 2014, In: Biomacromolecules. 15, 6, p. 2172-2179 8 p.
    • Role of calmodulin in neuronal Kv7/KCNQ potassium channels and epilepsy Chung, H. J., Jun 1 2014, In: Frontiers in Biology. 9, 3, p. 205-215 11 p.
    • Small quantum dots conjugated to nanobodies as immunofluorescence probes for nanometric microscopy Wang, Y., Cai, E., Rosenkranz, T., Ge, P., Teng, K. W., Lim, S. J., Smith, A. M., Chung, H. J., Sachs, F., Green, W. N., Gottlieb, P. and Selvin, P. R., Dec 17 2014, In: Bioconjugate Chemistry. 25, 12, p. 2205-2211 7 p.
    • Stable small quantum dots for synaptic receptor tracking on live neurons Cai, E., Ge, P., Lee, S. H., Jeyifous, O., Wang, Y., Liu, Y., Wilson, K. M., Lim, S. J., Baird, M. A., Stone, J. E., Lee, K. Y., Davidson, M. W., Chung, H. J., Schulten, K. J., Smith, A. M., Green, W. N. and Selvin, P. R., Nov 10 2014, In: Angewandte Chemie - International Edition. 53, 46, p. 12484-12488 5 p.


    • Repeated Cocaine Weakens GABAB-Girk Signaling in Layer 5/6 Pyramidal Neurons in the Prelimbic Cortex Hearing, M., Kotecki, L., MarronFernandezdeVelasco, E., Fajardo-Serrano, A., Chung, H. J., Luján, R. and Wickman, K., Oct 2 2013, In: Neuron. 80, 1, p. 159-170 12 p.


    • Constructing a road map from synapses to behaviour. Meeting on Synapses: From Molecules to Circuits and Behavior Chung, H. J. and Lee, H. K., 2009, In: EMBO Reports. 10, 9, p. 958-962 5 p.
    • G protein-activated inwardly rectifying potassium channels mediate depotentiation of long-term potentiation Hee, J. C., Ge, W. P., Qian, X., Wiser, O., Yuh, N. J. and Jan, L. Y., Jan 13 2009, In: Proceedings of the National Academy of Sciences of the United States of America. 106, 2, p. 635-640 6 p.
    • Neuronal activity regulates phosphorylation-dependent surface delivery of G protein-activated inwardly rectifying potassium channels Hee, J. C., Qian, X., Ehlers, M., Yuh, N. J. and Jan, L. Y., Jan 13 2009, In: Proceedings of the National Academy of Sciences of the United States of America. 106, 2, p. 629-634 6 p.


    • Channeling to the Nucleus Chung, H. J. and Jan, L. Y., Dec 21 2006, In: Neuron. 52, 6, p. 937-940 4 p.
    • Polarized axonal surface expression of neuronal KCNQ channels is mediated by multiple signals in the KCNQ2 and KCNQ3 C-terminal domains Chung, H. J., Jan, Y. N. and Jan, L. Y., Jun 6 2006, In: Proceedings of the National Academy of Sciences of the United States of America. 103, 23, p. 8870-8875 6 p.


    • Regulation of the NMDA receptor complex and trafficking by activity-dependent phosphorylation of the NR2B subunit PDZ ligand Hee, J. C., Yan, H. H., Lau, L. F. and Huganir, R. L., Nov 10 2004, In: Journal of Neuroscience. 24, 45, p. 10248-10259 12 p.


    • Molecular mechanism for loss of visual cortical responsiveness following brief monocular deprivation Heynen, A. J., Yoon, B. J., Liu, C. H., Chung, H. J., Huganir, R. L. and Bear, M. F., Aug 1 2003, In: Nature Neuroscience. 6, 8, p. 854-862 9 p.
    • Requirement of AMPA receptor GluR2 phosphorylation for cerebellar long-term depression Chung, H. J., Steinberg, J. P., Huganir, R. L. and Linden, D. J., Jun 13 2003, In: Science. 300, 5626, p. 1751-1755 5 p.


    • Identification of protein kinase C phosphorylation sites within the AMPA receptor GluR2 subunit McDonald, B. J., Chung, H. J. and Huganir, R. L., 2001, In: Neuropharmacology. 41, 6, p. 672-679 8 p.
    • Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression Kim, C. H., Hee Jung Chung, J. C., Lee, H. K. and Huganir, R. L., Sep 25 2001, In: Proceedings of the National Academy of Sciences of the United States of America. 98, 20, p. 11725-11730 6 p.


    • Phosphorylation of the AMPA receptor subunit GluR2 differentially regulates its interaction with PDZ domain-containing proteins Hee Jung Chung, J. C., Xia, J., Scannevin, R. H., Zhang, X. and Huganir, R. L., Oct 1 2000, In: Journal of Neuroscience. 20, 19, p. 7258-7267 10 p.