Zeynep Madak-Erdogan's directory photo.

Zeynep Madak-Erdogan

Associate Professor

Primary Affiliation

Multimodal Vascular Imaging


Status Affiliate Faculty

Home Department of Food Science and Human Nutrition

Phone 300-9063



  • Biography

    Dr. Madak-Erdogan is the Sylvia D. Stroup Scholar of Nutrition and Cancer, Associate Professor of Nutrition, Health Innovation Professor, and the Director of Women’s Health, Hormones and Metabolism lab at the University of Illinois, Urbana Champaign. She is also the Education Program Leader at Cancer Center at Illinois. She received her Ph.D. and undertook postdoctoral studies on mechanisms of estrogen receptor action at UIUC, then joined the Department of Food Science and Human Nutrition in 2014. In addition to mentoring several undergraduate and graduate students, she has taught courses in Cancer Metabolism, Basic Toxicology, Diet, Nutrition and Cancer, and Nutrition and Women’s Health. She has received several awards including a Pre- and Postdoctoral Research Training Program in Endocrine Developmental and Reproductive Toxicology Fellowships from the National Institute of Environmental Health Sciences, a fellowship from the National Center for Supercomputing Applications, the Women in Endocrinology Young Investigator Award from the Endocrine Society, and the Mary Swartz Rose Young Investigator Award and Bio-Serv Experimental Nutrition Award from the American Society for Nutrition. She is the Editor-in-Chief of the Journal of the Endocrine Society.

  • Honors

    Mary Swartz Rose Young Investigator Award from American Society of Nutrition (2016); Scholars Travel Fund, Travel Award for presenting in ENDO meeting (2015); Scholars Travel Fund, Travel Award for presenting in Keystone Meeting (2015); Arnold O. Beckman Award (2015); ENDO Early Investigators Award (2015); Scholars Travel Fund, Travel Award (2015); Eugenia Rosemberg Memorial Fund, Abstract Travel Award (2015).

  • Research

    Dr. Madak-Erdogan uses systems biology approaches to understand how hormones and metabolism affect women’s health. Her lab uses various animal and 3D-reengineered models, as well as advanced statistical and computational analysis, to understand how nutrients, environmental toxicant exposures, and hormones impact metabolic health and hormone-dependent cancer outcomes. Topics of interest include investigating how breast tumors become deadly; how to leverage nutrition and diet to improve the efficacy of cancer treatments; and understanding the impact of hormones on women’s metabolic and cardiovascular health.

  • 2021

    • Arredondo Eve, A., Tunc, E., Liu, Y-J., Agrawal, S., Erbak Yilmaz, H., Emren, S. V., Akyildiz Akçay, F., Mainzer, L., Žurauskiene, J., & Madak Erdogan, Z. (2021). Identification of Circulating Diagnostic Biomarkers for Coronary Microvascular Disease in Postmenopausal Women Using Machine-Learning Techniques. Metabolites, 11(6), [339]. DOI: 10.3390/metabo11060339
    • Imir, O. B., Kaminsky, A. Z., Zuo, Q-Y., Liu, Y-J., Singh, R., Spinella, M. J., Irudayaraj, J., Hu, W-Y., Prins, G. S., & Madak Erdogan, Z. (2021). Per- and Polyfluoroalkyl Substance Exposure Combined with High-Fat Diet Supports Prostate Cancer Progression. Nutrients, 13(11). DOI: 10.3390/nu13113902
    • Sikora, M. J., Riggins, R. B., & Madak-Erdogan, Z. (2021). Making an IMPACT on Career Development for Early- And Mid-career Faculty. Endocrinology (United States), 162(3). DOI: 10.1210/endocr/bqaa247
    • Zuo, Q., Band, S., Kesavadas, M., & Madak Erdogan, Z. (2021). Obesity and Postmenopausal Hormone Receptor-positive Breast Cancer: Epidemiology and Mechanisms. Endocrinology (United States), 162(12). DOI: 10.1210/endocr/bqab195
    • Zuo, Q., Chen, K. L., Eve, A. A., Liu, Y. J., Kim, S. H., Katzenellenbogen, B. S., Katzenellenbogen, J. A., & Madak-Erdogan, Z. (2021). Pathway preferential estrogens prevent hepatosteatosis due to ovariectomy and high-fat diets. Nutrients, 13(10), [3334]. DOI: 10.3390/nu13103334


    • Cazier, J-B, Mainzer, LS, Ge, W, Žurauskiene, J & Madak-Erdogan, Z 2020, 'Health disparities research is enabled by data diversity but requires much tighter integration of collaborative efforts', Journal of Global Health, vol. 10, no. 2, pp. 020351. DOI: 10.7189/jogh.10.020351
    • Cotul, EK, Zuo, Q, Santaliz-Casiano, A, Imir, OB, Mogol, AN, Tunc, E, Duong, K, Lee, JK, Ramesh, R, Odukoya, E, Kesavadas, MP, Ziogaite, M, Smith, BP, Mao, C, Shapiro, DJ, Park, BH, Katzenellenbogen, BS, Daly, D, Aranda, E, O’Neill, JD, Walker, C, Landesman, Y & Madak-Erdogan, Z 2020, 'Combined Targeting of Estrogen Receptor Alpha and Exportin 1 in Metastatic Breast Cancers', Cancers, vol. 12, no. 9, 2397, pp. 1-22. DOI: 10.3390/cancers12092397
    • Eve, AA, Liu, X, Wang, Y, Miller, MJ, Jeffery, EH & Madak-Erdogan, Z 2020, 'Biomarkers of Broccoli Consumption: Implications for Glutathione Metabolism and Liver Health', Nutrients, vol. 12, no. 9, 2514, pp. 1-16. DOI: 10.3390/nu12092514
    • Oktay, K, Santaliz-Casiano, A, Patel, M, Marino, N, Storniolo, AMV, Torun, H, Acar, B & Madak Erdogan, Z 2020, 'A Computational Statistics Approach to Evaluate Blood Biomarkers for Breast Cancer Risk Stratification', Hormones and Cancer, vol. 11, no. 1, pp. 17-33. DOI: 10.1007/s12672-019-00372-3
    • Smith, BP, Auvil, LS, Welge, M, Bushell, CB, Bhargava, R, Elango, N, Johnson, K & Madak-Erdogan, Z 2020, 'Identification of early liver toxicity gene biomarkers using comparative supervised machine learning', Scientific Reports, vol. 10, no. 1, 19128. DOI: 10.1038/s41598-020-76129-8
    • Tunc, E, Eve, AA & Madak-Erdogan, Z 2020, 'Coronary Microvascular Dysfunction and Estrogen Receptor Signaling', Trends in Endocrinology and Metabolism, vol. 31, no. 3, pp. 228-238. DOI: 10.1016/j.tem.2019.11.001
    • Zuo, Q & Madak Erdogan, Z 2020, 'The Window of Vulnerability for Uterus', Endocrinology, vol. 161, no. 8. DOI: 10.1210/endocr/bqaa104


    • Kulkoyluoglu-Cotul, E, Arca, A & Madak-Erdogan, Z 2019, 'Crosstalk between Estrogen Signaling and Breast Cancer Metabolism', Trends in Endocrinology and Metabolism, vol. 30, no. 1, pp. 25-38. DOI: 10.1016/j.tem.2018.10.006
    • Kulkoyluoglu-Cotul, E, Smith, BP, Wrobel, K, Zhao, YC, Chen, KLA, Hieronymi, K, Imir, OB, Duong, K, O’Callaghan, C, Mehta, A, Sahoo, S, Haley, B, Chang, H, Landesman, Y & Madak-Erdogan, Z 2019, 'Combined Targeting of Estrogen Receptor Alpha and XPO1 Prevent Akt Activation, Remodel Metabolic Pathways and Induce Autophagy to Overcome Tamoxifen Resistance', Cancers, vol. 11, no. 4, 479. DOI: 10.3390/cancers11040479
    • Madak-Erdogan, Z, Band, S, Zhao, YC, Smith, BP, Kulkoyluoglu-Cotul, E, Zuo, Q, Casiano, AS, Wrobel, K, Rossi, G, Smith, RL, Kim, SH, Katzenellenbogen, JA, Johnson, ML, Patel, M, Marino, N, Storniolo, AMV & Flaws, JA 2019, 'Free fatty acids rewire cancer metabolism in obesity-associated breast cancer via estrogen receptor and mTOR signaling', Cancer Research, vol. 79, no. 10, pp. 2494-2510. DOI: 10.1158/0008-5472.CAN-18-2849


    • Chen, KL & Madak-Erdogan, Z 2018, 'Estrogens and female liver health', Steroids, vol. 133, pp. 38-43. DOI: 10.1016/j.steroids.2017.10.015
    • Chen, KLA, Liu, X, Zhao, YC, Hieronymi, K, Rossi, G, Auvil, LS, Welge, M, Bushell, C, Smith, RL, Carlson, KE, Kim, SH, Katzenellenbogen, JA, Miller, MJ & Madak-Erdogan, Z 2018, 'Long-Term Administration of Conjugated Estrogen and Bazedoxifene Decreased Murine Fecal ß-Glucuronidase Activity Without Impacting Overall Microbiome Community', Scientific reports, vol. 8, no. 1, 8166. DOI: 10.1038/s41598-018-26506-1
    • Smith, BP & Madak-Erdogan, Z 2018, 'Urban Neighborhood and Residential Factors Associated with Breast Cancer in African American Women: a Systematic Review', Hormones and Cancer, vol. 9, no. 2, pp. 71-81. DOI: 10.1007/s12672-018-0325-x


    • Chen, KLA, Zhao, YC, Hieronymi, K, Smith, BP & Madak-Erdogan, Z 2017, 'Bazedoxifene and conjugated estrogen combination maintains metabolic homeostasis and benefits liver health', PloS one, vol. 12, no. 12, Y. DOI: 10.1371/journal.pone.0189911
    • Madak-Erdogan, Z, Charn, TH, Jiang, Y, Liu, ET, Katzenellenbogen, JA & Katzenellenbogen, BS 2017, 'Corrigendum to: Integrative genomics of gene and metabolic regulation by estrogen receptors and, and their coregulators (Molecular Systems Biology, (2014), 9, 1, (676), 10.1038/msb.2013.28)', Molecular Systems Biology, vol. 13, no. 4, 929. DOI: 10.15252/msb.20177595


    • Chambliss, K.L.; Barrera, J.; Umetani, M., Umetani, J.; Kim, S.H.; Madak-Erdogan,3 Z.; Katzenellenbogen,1 B.S.; Katzenellenbogen, J.A.; Mineo, C. and Shaul, P.W., Non-Nuclear Estrogen Receptor Activation and Cardiometabolic Disease Protection, in press Endocrinology
    • Gong P.; Madak-Erdogan,3 Z., Flaws J.A.; Shapiro D.J., Katzenellenbogen J.A., and Katzenellenbogen,1 B.S.; Estrogen Receptor-a and Aryl Hydrocarbon Receptor Involvement in the Actions of Botanical Estrogens in Target Cells, Mol Cell Endocrinol. 2016 Aug 16. PMID:27543265.
    • Kulkoyluoglu E.; Madak-Erdogan Z.; Role of nuclear and extranuclear estrogen receptor signaling in breast cancer, Steroids. 2016 Jul 6. PMID:27394959.
    • Madak-Erdogan Z., Kim SH, Gong P, Zhao YC, Zhang H, Chambliss KL, Carlson KE, Mayne CG, Shaul PW, Korach KS, Katzenellenbogen JA, Katzenellenbogen1 BS. Design of pathway preferential estrogens that provide beneficial metabolic and vascular effects without stimulating reproductive tissues. Science Signaling 2016 May 24;9(429):ra53. PubMed PMID: 27221711.
    • Wrobel, K.U.; Zhao, Y.C.; Kulkoyluoglu, E.; Chen, KL.; Hieronymi K.; Holloway, J.; Li, S.; Ray, T.; Ray, P.S.; Lipka, A.E.; Smith, R.L.; Madak-Erdogan, Z.; XPO1 Regulates tamoxifen responsiveness in estrogen receptor positive breast tumors by decreasing nuclear localization of ERK5, Mol Endocrinol. 2016 Aug PMID:27533791.
    • Zhao YC, Madak Erdogan Z. Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer. J Vis Exp. 2016 Mar 17;PubMed PMID: 27023311.


    • Kim, S.H.; Madak-Erdogan,3 Z.; Bae, S.C.; Carlson, K.; Mayne, C.; Granick, S.; Katzenellenbogen,1 B.S.; Katzenellenbogen, J.A., Ligand Accessibility and Bioactivity of a Hormone-Dendrimer Conjugate, Journal of the American Chemical Society 2015 Aug 19;137(32):10326-35.
    • Madak-Erdogan,3 Z.*; Gong, P., Zhao, YC, Xu, L.; Wrobel, K.U.; Hartman, J., Wang, M. Cam, A. Doerge, D., Khan, I.A., Katzenellenbogen, J.A., Katzenellenbogen,1 B.S., Helferich, 1 W.G., Dietary licorice root supplementation improves menopause associated metabolic syndrome and provides resiliency to high-fat diet *Corresponding author, Mol Nutr Food Res. 2015 Nov 10.
    • Madak-Erdogan,3 Z.; Gong, P., Katzenellenbogen,1 B.S., Differential Utilization of Nuclear and Extranuclear Receptor Signaling Pathways in the Actions of Estrogens, SERMs, and a Tissue- Selective Estrogen Complex (TSEC), J Steroid Biochem Mol Biol. 2015 Dec 12.


    • Bergamaschi, A., Madak-Erdogan,3 Z., Kim Y., Choi Y.L., Lu H. and Katzenellenbogen,1 B.S. The forkhead transcription factor FOXM1 promotes endocrine resistance and invasiveness in estrogen receptor-positive breast cancer by expansion of stem-like cancer cells., Breast Cancer Research. 2014 Sep 12;16(5):436. PMID:25213081.
    • Gong P.*, Madak-Erdogan,3 Z.*, Li J., Cheng J., Greenlief M., and Katzenellenbogen,1 B.S. Transcriptome Analyses Reveal Distinct Patterns of Gene Regulation by Different Botanical Estrogens in Dietary Supplements, Nuclear Receptor Signaling Atlas 2014 Sep 12 PMID:25363786 *Equal contribution.
    • Madak-Erdogan,3 Z., Ventrella R, Petry L., Katzenellenbogen1 BS, Novel Roles for ERK5 and Cofilin as Critical Mediators Linking ERalpha-Driven Transcription, Actin Reorganization and Invasiveness in Breast Cancer., Molecular Cancer Research, 2014 May;12(5):714-27, PMID: 24505128.


    • Jiang, Y., Gong, P., Madak-Erdogan,3 Z., Martin, T., Jeyakumar, M., Carlson, K., Khan, I., Smillie, T.J., Chittiboyina, A.G., Rotte S.C.K., Helferich, 1 W.G., Katzenellenbogen, J.A., Katzenellenbogen1, B.S., Mechanism Enforcing the Estrogen Receptor Beta-Selectivity of Botanical Estrogens, FASEB Journal 2013 Nov;27(11):4406-18, PMID: 23882126.
    • Kim K*, Madak-Erdogan,3 Z., Katzenellenbogen1, B.S., A MicroRNA196a2 and TP63 Circuit Regulated by Estrogen Receptor-a and ERK2 that Controls Breast Cancer Proliferation and Invasiveness Properties, Hormones and Cancer. 2013 Apr;4(2):78-91, PMID: 23250869 , *Equal contribution.
    • Madak-Erdogan,3 Z., Charn T.H, Jiang Y, Liu E.T., Katzenellenbogen J.A., Katzenellenbogen1, B.S., Integrative Genomics of Gene and Metabolic Regulation by Estrogen Receptors a and ß and Coregulators, Molecular Systems Biology 2013 Jun 18;9:676, PMID: 23774759.


    • Madak-Erdogan,3 Z., Katzenellenbogen1, B.S., Aryl Hydrocarbon Receptor Modulation of Estrogen Receptor-a-Mediated Gene Regulation by a Multimeric Chromatin Complex Involving the Two Receptors and the Coregulator RIP140, Toxicological Sciences. 2012 Feb;125(2):401-11, PMID:22071320.
    • Stossi F, Madak-Erdogan,3 Z, Katzenellenbogen1, B.S., ERK2 Acts Directly on Chromatin to Drive Macrophage-dependent Loss of Estrogen Receptor Alpha Expression in Breast Cancer Cells, Oncogene. 2012 Apr 5;31(14):1825-34, PMID:21860415.