Directory

Martin Burke's directory photo.

Martin Burke

Professor

Primary Affiliation

Artificial Intelligence for Materials

Affiliations

Status Part-time Faculty

Home Department of Chemistry

Phone 244-8726

Email mdburke@illinois.edu

Address 3257 Beckman Institute, 405 North Mathews Avenue

  • Biography

    Martin Burke is a professor in the Department of Chemistry and the May and Ving Lee Professor for Chemical Innovation at the University of Illinois Urbana-Champaign. He led the SHIELD Team at Illinois, and is also a professor in the Carle Illinois College of Medicine and the Carl R. Woese Institute for Genomic Biology.

    Education

    • B.A., chemistry, John Hopkins University, 1998

    • Ph.D., chemistry, Harvard University, 2003

    • M.D., health sciences and technology, Harvard Medical School and Massachusetts Institute of Technology, 2005

  • Honors

    • 2022: Elected, National Academy of Medicine

    • 2022: Fellow, American Association for the Advancement of Science

    • 2021: Presidential Medallion, University of Illinois 

    • 2021: Johns Hopkins University Distinguished Alumnus Award

    • 2021: LAS Impact Award, UIUC

    • 2021: Member, American Society for Clinical Investigation

    • 2019: iCON Award

    • 2019: Mukaiyama Award, Japan

    • 2017: American Chemical Society Nobel Laureate Award for Graduate Education

  • Research

    Research interests:

    • Synthesis

    • study of small molecules with protein-like functions

    Research in the Burke group focuses on the synthesis and study of small molecules with the capacity to perform protein-like functions. Ultimately, we envision such compounds serving as substitutes for missing or dysfunctional proteins, thereby operating as prostheses on the molecular scale. To enable these studies, we seek to develop new strategies and methods that make the process of complex small molecule synthesis as simple, efficient, and flexible as possible. We further aim to harness the power of this chemistry to illuminate the underpinnings of higher-order small molecule function in atomistic detail. Collectively, these efforts seek to make possible the development of molecular prosthetics as a general strategy for the understanding and betterment of human health.

  • 2024

    • Computational prediction of complex cationic rearrangement outcomes Klucznik, T., Syntrivanis, L. D., Bas, S., Mikulak-Klucznik, B., Moskal, M., Szymkuc, S., Mlynarski, J., Gadina, L., Beker, W., Burke, M. D., Tiefenbacher, K. and Grzybowski, B. A., Jan 18 2024, In: Nature. 625, 7995, p. 508-515 8 p.
    • Delocalized, asynchronous, closed-loop discovery of organic laser emitters Strieth-Kalthoff, F., Hao, H., Rathore, V., Derasp, J., Gaudin, T., Angello, N. H., Seifrid, M., Trushina, E., Guy, M., Liu, J., Tang, X., Mamada, M., Wang, W., Tsagaantsooj, T., Lavigne, C., Pollice, R., Wu, T. C., Hotta, K., Bodo, L. and Li, S. and 23 others, , May 17 2024, In: Science. 384, 6697, eadk9227.
    • Minimizing higher-order aggregation maximizes iron mobilization by small molecules Blake, A. D., Chao, J., SantaMaria, A. M., Ekaputri, S., Green, K. J., Brown, S. T., Rakowski, C. K., Choi, E. K., Aring, L., Chen, P. J., Snead, N. M., Matje, D. M., Geng, T., Octaviani, A., Bailey, K. L., Hollenbach, S. J., Fan, T. M., Seo, Y. A. and Burke, M. D., 2024, (Accepted/In press) In: Nature chemical biology.
    • Molecule Maker Lab Institute: Accelerating, advancing, and democratizing molecular innovation Burke, M. D., Denmark, S. E., Diao, Y., Han, J., Switzky, R. and Zhao, H., Mar 1 2024, In: AI Magazine. 45, 1, p. 117-123 7 p.

    2023

    • A Materials Acceleration Platform for Organic Laser Discovery Wu, T. C., Aguilar-Granda, A., Hotta, K., Yazdani, S. A., Pollice, R., Vestfrid, J., Hao, H., Lavigne, C., Seifrid, M., Angello, N., Bencheikh, F., Hein, J. E., Burke, M., Adachi, C. and Aspuru-Guzik, A., Feb 9 2023, In: Advanced Materials. 35, 6, 2207070.
    • MIDA- and TIDA-Boronates Stabilize a-Radicals Through B-N Hyperconjugation LaPorte, A. J., Feldner, J. E., Spies, J. C., Maher, T. J. and Burke, M. D., Oct 2 2023, In: Angewandte Chemie - International Edition. 62, 40, e202309566.
    • REACTION MINER: An Integrated System for Chemical Reaction Extraction from Textual Data Zhong, M., Ouyang, S., Jiao, Y., Kargupta, P., Luo, L., Shen, Y., Zhou, B., Zhong, X., Liu, X., Li, H., Xiao, J., Jiang, M., Hu, V., Wang, X., Ji, H., Burke, M., Zhao, H. and Han, J., 2023, p. 389-402. 14 p.
    • Segmental Dynamics of Membranous Cholesterol are Coupled Della Ripa, L. A., Courtney, J. M., Phinney, S. M., Borcik, C. G., Burke, M. D., Rienstra, C. M. and Pogorelov, T. V., Jul 19 2023, In: Journal of the American Chemical Society. 145, 28, p. 15043-15048 6 p.
    • Small Molecule-mediated Restoration Of Airway Surface Physiology In Human Cystic Fibrosis Lung Epithelia Burke, M. D. (Inventor) and Muraglia, K. A. (Inventor), Dec 26 2023, U.S. Patent No. 11850256
    • Synthetic drug kills fungi but spares kidney cells Maji, A. and Burke, M. D., 2023, (Accepted/In press) In: Nature.
    • Tuning sterol extraction kinetics yields a renal-sparing polyene antifungal Maji, A., Soutar, C. P., Zhang, J., Lewandowska, A., Uno, B. E., Yan, S., Shelke, Y., Murhade, G., Nimerovsky, E., Borcik, C. G., Arango, A. S., Lange, J. D., Marin-Toledo, J. P., Lyu, Y., Bailey, K. L., Roady, P. J., Holler, J. T., Khandelwal, A., SantaMaria, A. M. and Sanchez, H. and 18 others, , Nov 30 2023, In: Nature. 623, 7989, p. 1079-1085 7 p.

    2022

    • A small molecule redistributes iron in ferroportin-deficient mice and patient-derived primary macrophages Ekaputri, S., Choi, E. K., Sabelli, M., Aring, L., Green, K. J., Chang, J. O., Bao, K., Choi, H. S., Iwase, S., Kim, J., Corradini, E., Pietrangelo, A., Burke, M. D. and Seo, Y. A., Jun 28 2022, In: Proceedings of the National Academy of Sciences. 119, 26, e2121400119.
    • Automated iterative Csp3-C bond formation Blair, D. J., Chitti, S., Trobe, M., Kostyra, D. M., Haley, H. M. S., Hansen, R. L., Ballmer, S. G., Woods, T. J., Wang, W., Mubayi, V., Schmidt, M. J., Pipal, R. W., Morehouse, G. F., Palazzolo Ray, A. M. E., Gray, D. L., Gill, A. L. and Burke, M. D., Apr 7 2022, In: Nature. 604, 7904, p. 92-97 6 p.
    • CHEMICAL-REACTION-AWARE MOLECULE REPRESENTATION LEARNING Wang, H., Li, W., Jin, X., Cho, K., Ji, H., Han, J. and Burke, M. D., 2022.
    • Closed-loop optimization of general reaction conditions for heteroaryl Suzuki-Miyaura coupling Angello, N. H., Rathore, V., Beker, W., Wolos, A., Jira, E. R., Roszak, R., Wu, T. C., Schroeder, C. M., Aspuru-Guzik, A., Grzybowski, B. A. and Burke, M. D., Oct 28 2022, In: Science. 378, 6618, p. 399-405 7 p.
    • Digitizing Chemical Synthesis in 3D Printed Reactionware Bubliauskas, A., Blair, D. J., Powell-Davies, H., Kitson, P. J., Burke, M. D. and Cronin, L., Jun 13 2022, In: Angewandte Chemie - International Edition. 61, 24, e202116108.
    • Iterations from the chemical cosmos Loving, D. C. and Burke, M. D., Jan 2022, In: Nature Synthesis. 1, 1, p. 11-12 2 p.
    • Machine Learning May Sometimes Simply Capture Literature Popularity Trends: A Case Study of Heterocyclic Suzuki-Miyaura Coupling Beker, W., Roszak, R., Wolos, A., Angello, N. H., Rathore, V., Burke, M. D. and Grzybowski, B. A., Mar 23 2022, In: Journal of the American Chemical Society. 144, 11, p. 4819-4827 9 p.
    • Mitigation of SARS-CoV-2 transmission at a large public university Ranoa, D. R. E., Holland, R. L., Alnaji, F. G., Green, K. J., Wang, L., Fredrickson, R. L., Wang, T., Wong, G. N., Uelmen, J., Maslov, S., Weiner, Z. J., Tkachenko, A. V., Zhang, H., Liu, Z., Ibrahim, A., Patel, S. J., Paul, J. M., Vance, N. P., Gulick, J. G. and Satheesan, S. P. and 129 others, , Dec 2022, In: Nature communications. 13, 1, 3207.
    • Preparation of MIDA Anhydride and Reaction with Boronic Acids Chen, P. J., Kelly, A. M., Blair, D. J. and Burke, M. D., 2022, In: Organic Syntheses. 99, p. 92-112 21 p.
    • REACTCLASS: Cross-Modal Supervision for Subword-Guided Reactant Entity Classification Wang, X., Hu, V., Jiang, M., Zhang, Y., Xiao, J., Loving, D. C., Ji, H., Burke, M. and Han, J., 2022, Proceedings - 2022 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2022. Adjeroh, D., Long, Q., Shi, X., Guo, F., Hu, X., Aluru, S., Narasimhan, G., Wang, J., Kang, M., Mondal, A. M. and Liu, J. (eds.). Institute of Electrical and Electronics Engineers Inc., p. 844-847 4 p. (Proceedings - 2022 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2022).
    • Restoring Physiology In Iron-deficient Organisms Using Small Molecules Burke, M. D. (Inventor) and Grillo, A. S. (Inventor), Dec 6 2022, U.S. Patent No. 11517540
    • Saliva-based Molecular Testing For SARS-CoV-2 Burke, M. D. (Inventor), Fan, T. M. (Inventor), Hergenrother, P. J. (Inventor), Brooke, C. B. (Inventor), Ranoa, D. R. E. (Inventor), Holland, R. L. (Inventor), Alnaji, F. G. (Inventor), Green, K. J. (Inventor) and Wang, L. (Inventor), Dec 20 2022, U.S. Patent No. 11530457
    • Stereospecific Csp3Suzuki-Miyaura Cross-Coupling That Evades ß-Oxygen Elimination Laporte, A. J., Shi, Y., Hein, J. E. and Burke, M. D., Sep 2 2022, In: ACS Catalysis. p. 10905-10912 8 p.
    • Targeting fungal membrane homeostasis with imidazopyrazoindoles impairs azole resistance and biofilm formation Revie, N. M., Iyer, K. R., Maxson, M. E., Zhang, J., Yan, S., Fernandes, C. M., Meyer, K. J., Chen, X., Skulska, I., Fogal, M., Sanchez, H., Hossain, S., Li, S., Yashiroda, Y., Hirano, H., Yoshida, M., Osada, H., Boone, C., Shapiro, R. S. and Andes, D. R. and 7 others, , Dec 2022, In: Nature communications. 13, 1, 3634.
    • Using automated synthesis to understand the role of side chains on molecular charge transport Li, S., Jira, E. R., Angello, N. H., Li, J., Yu, H., Moore, J. S., Diao, Y., Burke, M. D. and Schroeder, C. M., Dec 2022, In: Nature communications. 13, 1, 2102.

    2021

    • Amphotericin B derivatives with improved therapeutic index Struble, J. (Inventor), Burke, M. D. (Inventor), Dailey, I. (Inventor), Palyam, N. (Inventor), Knapp, D. M. (Inventor), Wang, P. (Inventor), Davis, S. A. (Inventor), Uno, B. E. (Inventor) and Gray, K. C. (Inventor), Jun 8 2021, U.S. Patent No. 11028114
    • Amphotericin B derivatives with improved therapeutic index Struble, J. (Inventor), Burke, M. D. (Inventor), Dailey, I. (Inventor), Palyam, N. (Inventor), Knapp, D. M. (Inventor), Wang, P. (Inventor), Davis, S. A. (Inventor), Uno, B. E. (Inventor) and Gray, K. C. (Inventor), Sep 14 2021, U.S. Patent No. 11117920, Jun 17 2019
    • Amphotericin B induces epithelial voltage responses in people with cystic fibrosis Chorghade, R. S., Kim, B. R., Launspach, J. L., Karp, P. H., Welsh, M. J. and Burke, M. D., May 2021, In: Journal of Cystic Fibrosis. 20, 3, p. 540-550 11 p.
    • Fungicidal amphotericin B sponges are assemblies of staggered asymmetric homodimers encasing large void volumes Lewandowska, A., Soutar, C. P., Greenwood, A. I., Nimerovsky, E., De Lio, A. M., Holler, J. T., Hisao, G. S., Khandelwal, A., Zhang, J., SantaMaria, A. M., Schwieters, C. D., Pogorelov, T. V., Burke, M. and Rienstra, C., Dec 2021, In: Nature Structural Biology. 28, 12, p. 972-981 10 p.
    • Hybrid Amphotericin B derivatives with reduced toxicity Burke, M. D. (Inventor), Khandelwal, A. (Inventor), Zhang, J. (Inventor) and SantaMaria, A. (Inventor), Dec 14 2021, U.S. Patent No. 11198705, Sep 6 2019
    • Sterol Sponge Mechanism Is Conserved for Glycosylated Polyene Macrolides Guo, X., Zhang, J., Li, X., Xiao, E., Lange, J. D., Rienstra, C. M., Burke, M. D. and Mitchell, D. A., May 26 2021, In: ACS Central Science. 7, 5, p. 781-791 11 p.
    • Transition between Nonresonant and Resonant Charge Transport in Molecular Junctions Li, S., Yu, H., Li, J., Angello, N., Jira, E. R., Li, B., Burke, M. D., Moore, J. S. and Schroeder, C. M., Oct 13 2021, In: Nano letters. 21, 19, p. 8340-8347 8 p.
    • Validation of a molecular assay to detect SARS-CoV-2 in saliva Pitman, J. L., Morris, A. J., Grice, S., Walsh, J. T., Wang, L., Burke, M. D. and Dixon-McIver, A., Dec 17 2021, In: New Zealand Medical Journal. 134, 1547, p. 14-27 14 p.
    • Well-Tolerated Amphotericin B Derivatives That Effectively Treat Visceral Leishmaniasis Morelle, C., Mukherjee, A., Zhang, J., Fani, F., Khandelwal, A., Gingras, H., Trottier, J., Barbier, O., Leprohon, P., Burke, M. D. and Ouellette, M., Aug 13 2021, In: ACS Infectious Diseases. 7, 8, p. 2472-2482 11 p.

    2020

    • A Computer Conquers Tactical Combinations Blair, D. J. and Burke, M. D., Jan 9 2020, In: Chem. 6, 1, p. 12-13 2 p.
    • A Mild Method for Making MIDA Boronates Kelly, A. M., Chen, P. J., Klubnick, J., Blair, D. J. and Burke, M. D., Dec 18 2020, In: Organic Letters. 22, 24, p. 9408-9414 7 p.
    • Automated synthesis of small molecules using chiral, non-racemic boronates Gillis, E. P. (Inventor), Burke, M. D. (Inventor) and Li, J. (Inventor), Aug 25 2020, U.S. Patent No. 10752577
    • Modular synthesis enables molecular ju-jitsu in the fight against antibiotic resistance Blair, D. J. and Burke, M. D., Oct 1 2020, In: Nature. 586, 7827, p. 32-33 2 p.
    • Protected organoboronic acids with tunable reactivity, and methods of use thereof Burke, M. D. (Inventor), Schmidt, M. J. (Inventor), Morehouse, G. (Inventor) and Pipal, R. W. (Inventor), Nov 24 2020, U.S. Patent No. 10844081
    • Saliva-Based Molecular Testing for SARS-CoV-2 that Bypasses RNA Extraction Ranoa, D. R. E., Holland, R. L., Alnaji, F. G., Green, K. J., Wang, L., Brooke, C. B., Burke, M., Fan, T. M. and Hergenrother, P., Jun 18 2020, (In preparation) Cold Spring Harbor Laboratory Press, 35 p. (bioRxiv).
    • Scalable synthesis of reduced toxicity derivative of amphotericin B Burke, M. D. (Inventor), Uno, B. E. (Inventor) and Rakshit, S. (Inventor), Jun 16 2020, U.S. Patent No. 10683318
    • Small Molecule Channels Harness Membrane Potential to Concentrate Potassium in trk1?trk2? Yeast Hou, J., Daniels, P. N. and Burke, M. D., Jun 19 2020, In: ACS chemical biology. 15, 6, p. 1575-1580 6 p.

    2019

    • Amphotericin B derivatives with improved therapeutic index Struble, J. (Inventor), Burke, M. D. (Inventor), Dailey, I. (Inventor), Palyam, N. (Inventor), Knapp, D. M. (Inventor), Wang, P. (Inventor), Davis, S. A. (Inventor), Uno, B. E. (Inventor) and Gray, K. C. (Inventor), Jun 18 2019, U.S. Patent No. 10323057
    • Automated synthesis of small molecules using chiral, non-racemic boronates Gillis, E. P. (Inventor), Burke, M. D. (Inventor) and Li, J. (Inventor), Mar 26 2019, U.S. Patent No. 10239824
    • Axial shielding of Pd(II) complexes enables perfect stereoretention in Suzuki-Miyaura cross-coupling of Csp3 boronic acids Lehmann, J. W., Crouch, I. T., Blair, D. J., Trobe, M., Wang, P., Li, J. and Burke, M. D., Dec 1 2019, In: Nature communications. 10, 1, 1263.
    • Modular Syntheses of Phenanthroindolizidine Natural Products Jo, Y. I., Burke, M. D. and Cheon, C. H., Jun 7 2019, In: Organic Letters. 21, 11, p. 4201-4204 4 p.
    • Small-molecule ion channels increase host defences in cystic fibrosis airway epithelia Muraglia, K. A., Chorghade, R. S., Kim, B. R., Tang, X. X., Shah, V. S., Grillo, A. S., Daniels, P. N., Cioffi, A. G., Karp, P. H., Zhu, L., Welsh, M. J. and Burke, M. D., Mar 21 2019, In: Nature. 567, 7748, p. 405-408 4 p.
    • Stereoretentive cross-coupling of boronic acids Burke, M. D. (Inventor), Crouch, I. (Inventor), Lehmann, J. W. (Inventor), Palazzolo, A. M. E. (Inventor) and Simons, C. M. (Inventor), Aug 6 2019, U.S. Patent No. 10370393

    2018

    • Apparatus and methods for the automated synthesis of small molecules Gillis, E. P. (Inventor), Burke, M. D. (Inventor) and Ballmer, S. G. (Inventor), Jan 9 2018, U.S. Patent No. 9862733
    • Cross-coupling of unactivated secondary boronic acids Crouch, I. (Inventor), Burke, M. D. (Inventor) and Wang, P. (Inventor), Sep 11 2018, U.S. Patent No. 10072028
    • FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity Yien, Y. Y., Shi, J., Chen, C., Cheung, J. T. M., Grillo, A. S., Shrestha, R., Li, L., Zhang, X., Kafina, M. D., Kingsley, P. D., King, M. J., Ablain, J., Li, H., Zon, L. I., Palis, J., Burke, M. D., Bauer, D. E., Orkin, S. H., Koehler, C. M. and Phillips, J. D. and 4 others, , Dec 21 2018, In: Journal of Biological Chemistry. 293, 51, p. 19797-19811 15 p.
    • Methods for forming protected organoboronic acids Burke, M. D. (Inventor), Dick, G. R. (Inventor), Knapp, D. M. (Inventor), Gillis, E. P. (Inventor) and Klubnick, J. A. (Inventor), Mar 6 2018, U.S. Patent No. 9908900
    • Peridinin Is an Exceptionally Potent and Membrane-Embedded Inhibitor of Bilayer Lipid Peroxidation Haley, H. M. S., Hill, A. G., Greenwood, A. I., Woerly, E. M., Rienstra, C. M. and Burke, M. D., Nov 14 2018, In: Journal of the American Chemical Society. 140, 45, p. 15227-15240 14 p.
    • Scalable synthesis of reduced toxicity derivative of amphotericin B Burke, M. D. (Inventor), Uno, B. E. (Inventor) and Rakshit, S. (Inventor), Oct 2 2018, U.S. Patent No. 10087206
    • Solid-State NMR of highly 13C-enriched cholesterol in lipid bilayers Della Ripa, L. A., Petros, Z. A., Cioffi, A. G., Piehl, D. W., Courtney, J. M., Burke, M. D. and Rienstra, C. M., Apr 1 2018, In: Methods. 138-139, p. 47-53 7 p.
    • The Molecular Industrial Revolution: Automated Synthesis of Small Molecules Trobe, M. and Burke, M. D., Apr 9 2018, In: Angewandte Chemie - International Edition. 57, 16, p. 4192-4214 23 p.
    • Towards the generalized iterative synthesis of small molecules Lehmann, J. W., Blair, D. J. and Burke, M. D., 2018, In: Nature Reviews Chemistry. 2, 2, 0115.

    2017

    • Amphotericin B derivative with reduced toxicity Burke, M. D. (Inventor) and Uno, B. E. (Inventor), Aug 22 2017, U.S. Patent No. 9738677
    • Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals Grillo, A. S., SantaMaria, A. M., Kafina, M. D., Cioffi, A. G., Huston, N. C., Han, M., Seo, Y. A., Yien, Y. Y., Nardone, C., Menon, A. V., Fan, J., Svoboda, D. C., Anderson, J. B., Hong, J. D., Nicolau, B. G., Subedi, K., Gewirth, A. A., Wessling-Resnick, M., Kim, J. and Paw, B. H. and 1 others, , May 12 2017, In: Science. 356, 6338, p. 608-616 9 p.
    • Slow release of organoboronic acids in cross-coupling reactions Gillis, E. P. (Inventor), Burke, M. D. (Inventor) and Knapp, D. M. (Inventor), Dec 19 2017, U.S. Patent No. 9845317
    • System for controlling the reactivity of boronic acids Burke, M. D. (Inventor) and Gillis, E. P. (Inventor), Aug 15 2017, U.S. Patent No. 9732102
    • The natural productome Palazzolo, A. M. E., Simons, C. L. W. and Burke, M. D., May 30 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 22, p. 5564-5566 3 p.

    2016

    • Apparatus and methods for the automated synthesis of small molecules Gillis, E. P. (Inventor), Burke, M. D. (Inventor) and Ballmer, S. G. (Inventor), Jan 19 2016, U.S. Patent No. 9238597
    • Automated synthesis of small molecules using chiral, non-racemic boronates Gillis, E. P. (Inventor), Burke, M. D. (Inventor) and Li, J. (Inventor), Jul 12 2016, U.S. Patent No. 9388131
    • Methods for forming protected organoboronic acids Burke, M. D. (Inventor), Dick, G. R. (Inventor), Knapp, D. M. (Inventor), Gillis, E. P. (Inventor) and Klubnick, J. A. (Inventor), May 31 2016, U.S. Patent No. 9353131
    • MIDA boronates are hydrolysed fast and slow by two different mechanisms Gonzalez, J. A., Ogba, O. M., Morehouse, G. F., Rosson, N., Houk, K. N., Leach, A. G., Cheong, P. H. Y., Burke, M. D. and Lloyd-Jones, G. C., Nov 1 2016, In: Nature Chemistry. 8, 11, p. 1067-1075 9 p.
    • Our Path to Less Toxic Amphotericins Endo, M. M., Cioffi, A. G. and Burke, M. D., Feb 12 2016, In: Synlett. 27, 3, p. 337-354 18 p.
    • Slow release of organoboronic acids in cross-coupling reactions Gillis, E. P. (Inventor), Burke, M. D. (Inventor) and Knapp, D. M. (Inventor), May 3 2016, U.S. Patent No. 9328102
    • System for controlling the reactivity of boronic acids Lee, S. J. (Inventor), Gillis, E. P. (Inventor), Burke, M. D. (Inventor), Knapp, D. M. (Inventor) and Gray, K. C. (Inventor), May 3 2016, U.S. Patent No. 9328127

    2015

    • Automated synthesis of small molecules using chiral, non-racemic boronates Gillis, E. P. (Inventor), Burke, M. D. (Inventor) and Li, J. (Inventor), Apr 21 2015, U.S. Patent No. 9012658
    • C3-OH of Amphotericin B Plays an Important Role in Ion Conductance Davis, S. A., Della Ripa, L. A., Hu, L., Cioffi, A. G., Pogorelov, T. V., Rienstra, C. M. and Burke, M. D., Dec 9 2015, In: Journal of the American Chemical Society. 137, 48, p. 15102-15104 3 p.
    • From Synthesis to Function via Iterative Assembly of N-Methyliminodiacetic Acid Boronate Building Blocks Li, J., Grillo, A. S. and Burke, M. D., Jul 22 2015, In: Accounts of chemical research. 48, 8, p. 2297-2307 11 p.
    • Nontoxic antimicrobials that evade drug resistance Davis, S. A., Vincent, B. M., Endo, M. M., Whitesell, L., Marchillo, K., Andes, D. R., Lindquist, S. and Burke, M. D., Jul 20 2015, In: Nature chemical biology. 11, 7, p. 481-487 7 p.
    • Restored physiology in protein-deficient yeast by a small molecule channel Cioffi, A. G., Hou, J., Grillo, A. S., Diaz, K. A. and Burke, M. D., Aug 19 2015, In: Journal of the American Chemical Society. 137, 32, p. 10096-10099 4 p.
    • Slow release of organoboronic acids in cross-coupling reactions Gillis, E. P. (Inventor), Burke, M. D. (Inventor) and Knapp, D. M. (Inventor), Apr 14 2015, U.S. Patent No. 9006463
    • Synthesis of many different types of organic small molecules using one automated process Li, J., Ballmer, S. G., Gillis, E. P., Fujii, S., Schmidt, M. J., Palazzolo, A. M. E., Lehmann, J. W., Morehouse, G. F. and Burke, M. D., Mar 13 2015, In: Science. 347, 6227, p. 1221-1226 6 p.

    2014

    • Amphotericin forms an extramembranous and fungicidal sterol sponge Anderson, T. M., Clay, M. C., Cioffi, A. G., Diaz, K. A., Hisao, G. S., Tuttle, M. D., Nieuwkoop, A. J., Comellas, G., Maryum, N., Wang, S., Uno, B. E., Wildeman, E. L., Gonen, T., Rienstra, C. M. and Burke, M. D., May 2014, In: Nature chemical biology. 10, 5, p. 400-406 7 p.
    • Synthesis of most polyene natural product motifs using just 12 building blocks and one coupling reaction Woerly, E. M., Roy, J. and Burke, M. D., Jun 2014, In: Nature Chemistry. 6, 6, p. 484-491 8 p.

    2013

    • (1-Bromovinyl)-MIDA boronate: A readily accessible and highly versatile building block for small molecule synthesis Dedicated to Professor Paul Wender with deepest admiration on his receipt of the 2012 Tetrahedron Prize for Creativity in Organic Chemistry Woerly, E. M., Miller, J. E. and Burke, M. D., Sep 9 2013, In: Tetrahedron. 69, 36, p. 7732-7740 9 p.
    • C2'-OH of amphotericin B plays an important role in binding the primary sterol of human cells but not yeast cells Wilcock, B. C., Endo, M. M., Uno, B. E. and Burke, M. D., Jun 12 2013, In: Journal of the American Chemical Society. 135, 23, p. 8488-8491 4 p.
    • Methods for forming protected organoboronic acids Gillis, E. P. (Inventor), Burke, M. D. (Inventor), Klubnick, J. A. (Inventor), Dick, G. R. (Inventor), Knapp, D. M. (Inventor) and Uno, B. E. (Inventor), Oct 15 2013, U.S. Patent No. 8557980

    2012

    • A general solution for the 2-pyridyl problem Dick, G. R., Woerly, E. M. and Burke, M. D., Mar 12 2012, In: Angewandte Chemie - International Edition. 51, 11, p. 2667-2672 6 p.
    • Amphotericin primarily kills yeast by simply binding ergosterol Gray, K. C., Palacios, D. S., Dailey, I., Endo, M. M., Uno, B. E., Wilcock, B. C. and Burke, M. D., Feb 14 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 7, p. 2234-2239 6 p.
    • Electronic tuning of site-selectivity Wilcock, B. C., Uno, B. E., Bromann, G. L., Clark, M. J., Anderson, T. M. and Burke, M. D., Dec 2012, In: Nature Chemistry. 4, 12, p. 996-1003 8 p.
    • Slow release of organoboronic acids in cross-coupling reactions Gillis, E. P. (Inventor), Burke, M. D. (Inventor) and Knapp, D. M. (Inventor), Dec 25 2012, U.S. Patent No. 8338601
    • System for controlling the reactivity of boronic acids Lee, S. J. (Inventor), Gillis, E. P. (Inventor), Burke, M. D. (Inventor), Knapp, D. M. (Inventor) and Gray, K. C. (Inventor), Nov 27 2012, U.S. Patent No. 8318983

    2011

    • (Z)-(2-bromovinyl)-MIDA boronate: A readily accessible and highly versatile building block for small molecule synthesis Woerly, E. M., Struble, J. R., Palyam, N., O'Hara, S. P. and Burke, M. D., Jun 17 2011, In: Tetrahedron. 67, 24, p. 4333-4343 11 p.
    • A simple and general platform for generating stereochemically complex polyene frameworks by iterative cross-coupling Lee, S. J., Anderson, T. M. and Burke, M. D., Nov 15 2010, In: Angewandte Chemie - International Edition. 49, 47, p. 8860-8863 4 p.
    • Ethynyl MIDA boronate: A readily accessible and highly versatile building block for small molecule synthesis Struble, J. R., Lee, S. J. and Burke, M. D., Jun 26 2010, In: Tetrahedron. 66, 26, p. 4710-4718 9 p.
    • General method for synthesis of 2-heterocyclic N-methyliminodiacetic acid boronates Dick, G. R., Knapp, D. M., Gillis, E. P. and Burke, M. D., May 21 2010, In: Organic Letters. 12, 10, p. 2314-2317 4 p.
    • Pinene-derived iminodiacetic acid (PIDA): A powerful ligand for stereoselective synthesis and iterative cross-coupling of C(sp 3) boronate building blocks Li, J. and Burke, M. D., Sep 7 2011, In: Journal of the American Chemical Society. 133, 35, p. 13774-13777 4 p.
    • Synthesis-enabled functional group deletions reveal key underpinnings of amphotericin B ion channel and antifungal activities Palacios, D. S., Dailey, I., Siebert, D. M., Wilcock, B. C. and Burke, M. D., Apr 26 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 17, p. 6733-6738 6 p.
    • System for controlling the reactivity of boronic acids Burke, M. D. (Inventor), Gillis, E. P. (Inventor), Lee, S. J. (Inventor), Knapp, D. M. (Inventor) G and ray, K. C. (Inventor), Sep 6 2011, U.S. Patent No. 8013203
    • Total synthesis of synechoxanthin through iterative cross-coupling Fujii, S., Chang, S. Y. and Burke, M. D., Aug 16 2011, In: Angewandte Chemie - International Edition. 50, 34, p. 7862-7864 3 p.

    2010

    • Stereoretentive suzuki-miyaura coupling of haloallenes enables fully stereocontrolled access to (-)-Peridinin Woerly, E. M., Cherney, A. H., Davis, E. K. and Burke, M. D., May 26 2010, In: Journal of the American Chemical Society. 132, 20, p. 6941-6943 3 p.

    2009

    • A general solution for unstable boronic acids: Slow-release cross-coupling from air-stable MIDA boronates Knapp, D. M., Gillis, E. P. and Burke, M. D., May 27 2009, In: Journal of the American Chemical Society. 131, 20, p. 6961-6963 3 p.
    • B-protected haloboronic acids for iterative cross-coupling Ballmer, S. G., Gillis, E. P., Burke, M. D., Morton, D. and Davies, H. M. L., 2009, In: Organic Syntheses. 86, p. 344-359 16 p.
    • Flexible tetracycline synthesis yields promising antibiotics Burke, M. D., Feb 6 2009, In: Nature chemical biology. 5, 2, p. 77-79 3 p.
    • Iterative cross-coupling with MIDA boronates: Towards a general strategy for small-molecule synthesis Gillis, E. P. and Burke, M. D., 2009, In: Aldrichimica Acta. 42, 1, p. 17-27 11 p.
    • Vinyl MIDA boronate: a readily accessible and highly versatile building block for small molecule synthesis Uno, B. E., Gillis, E. P. and Burke, M. D., Apr 18 2009, In: Tetrahedron. 65, 16, p. 3130-3138 9 p.

    2008

    • Multistep synthesis of complex boronic acids from simple MIDA boronates Gillis, E. P. and Burke, M. D., Oct 29 2008, In: Journal of the American Chemical Society. 130, 43, p. 14084-14085 2 p.
    • Simple, efficient, and modular syntheses of polyene natural products via iterative cross-coupling Suk, J. L., Gray, K. C., Paek, J. S. and Burke, M. D., Jan 16 2008, In: Journal of the American Chemical Society. 130, 2, p. 466-468 3 p.

    2007

    • A post-PKS oxidation of the amphotericin B skeleton predicted to be critical for channel formation is not required for potent antifungal activity Palacios, D. S., Anderson, T. M. and Burke, M. D., Nov 14 2007, In: Journal of the American Chemical Society. 129, 45, p. 13804-13805 2 p.
    • A simple and modular strategy for small molecule synthesis: Iterative Suzuki-Miyaura coupling of B-protected haloboronic acid building blocks Gillis, E. P. and Burke, M. D., May 30 2007, In: Journal of the American Chemical Society. 129, 21, p. 6716-6717 2 p.

    2004

    • A Planning Strategy for Diversity-Oriented Synthesis Burke, M. D. and Schreiber, S. L., Dec 22 2004, In: Angewandte Chemie - International Edition. 43, 1, p. 46-58 13 p.
    • A synthesis strategy yielding skeletally diverse small molecules combinatorially Burke, M. D., Berger, E. M. and Schreiber, S. L., Nov 3 2004, In: Journal of the American Chemical Society. 126, 43, p. 14095-14104 10 p.

    2003

    • Chemoenzymatic route to macrocyclic hybrid peptide/polyketide-like molecules Kohli, R. M., Burke, M. D., Tao, J. and Walsh, C. T., Jun 18 2003, In: Journal of the American Chemical Society. 125, 24, p. 7160-7161 2 p.
    • Generating Diverse Skeletons of Small Molecules Combinatorially Burke, M. D., Berger, E. M. and Schreiber, S. L., Oct 24 2003, In: Science. 302, 5645, p. 613-618 6 p.

    2002

    • Teaching target-oriented and diversity-oriented organic synthesis at Harvard University Burke, M. D. and Lalic, G., 2002, In: Chemistry and Biology. 9, 5, p. 535-541 7 p.

    2001

    • Conformationally restricted hybrid analogues of the hormone 1a,25-dihydroxyvitamin D3: Design, synthesis, and biological evaluation White, M. C., Burke, M. D., Peleg, S., Brem, H. and Posner, G. H., 2001, In: Bioorganic and Medicinal Chemistry. 9, 7, p. 1691-1699 9 p.

    1998

    • Noncalcemic, antiproliferative, transcriptionally active, 24-fluorinated hybrid analogues of the hormone 1a,25-dihydroxyvitamin D3. Synthesis and preliminary biological evaluation Posner, G. H., Lee, J. K., Wang, Q., Peleg, S., Burke, M., Brem, H., Dolan, P. and Kensler, T. W., Jul 30 1998, In: Journal of Medicinal Chemistry. 41, 16, p. 3008-3014 7 p.