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Biography
James Hinman is an assistant professor in the Department of Psychology. His primary affiliation is Brain Connectivity and Networks.
Education
B.A., psychology, University of Connecticut, 2006
Ph.D., M.A., behavioral neuroscience, University of Connecticut, 2012
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Honors
2018: Interdisciplinary Navigation Symposium Best Poster award
2011: Doctoral Dissertation Fellowship, University of Connecticut
2011: Graduate Summer Research Award, University of Connecticut
2008-2010: Neuroscience Fellowship, University of Connecticut
2005,2006: New England Scholar, University of Connecticut
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Research
Research Areas:
Behavioral Neuroscience
Egocentric Spatial Coding
Allocentric Spatial Coding
Oscillatory Dynamics
Research Interests:
Spatial cognition
Spatial navigation
Learning & memory
Electrophysiology
Autism
The Hinman lab is broadly interested in spatial cognition and memory. The lab investigates how the brain represents space in order to navigate the world. To those ends they employ high-density electrophysiology and calcium imaging in freely behaving rats in order to record/image large populations of individual neurons from brain regions such as hippocampus, entorhinal cortex, retrosplenial cortex, and striatum while rats engage in a variety of tasks. Such data allows the Hinman Lab to identify the coding properties of individual neurons, as well as investigate the structure of population coding.
An important feature of many environments is the social landscape. Knowing who is around you is critically important for many animal species and the Hinman lab is investigating how the brain dynamically represents the spatial location of conspecifics, whether that conspecific is higher or lower in the social hierarchy or a complete stranger. By monitoring cohabitating groups of rats during adolescence they identify the social relationship between each member of the group and then record or image neural activity during social interactions between pairs of rats with a known relationship. By incorporating genetic Autism model rats in the group they are investigating how the neural representation of others is altered in animals with known differences in social interactions.
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2020
- lexander, A. S., Carstensen, L. C., Hinman, J. R., Raudies, F., William Chapman, G., & Hasselmo, M. E. (2020). Egocentric boundary vector tuning of the retrosplenial cortex. Science Advances, 6(8), [eaaz2322]. https://doi.org/10.1126/sciadv.aaz2322
2019
- Alexander AS, Carstensen L, Hinman JR, Raudies F, Chapman GW, Hasselmo ME (2019) Egocentric boundary vector tuning of the retrosplenial cortex. bioRxiv doi:https://doi.org/10.1101/702712.
- Alexander AS, Carstensen LC, Chapman GW, Raudies F, Hinman JR, Hasselmo ME (2019) Egocentric boundary vector tuning of the retrosplenial cortex. Soc. Neurosci. Abstr.
- Hinman, J. R., Chapman, G. W., & Hasselmo, M. E. (2019). Neuronal representation of environmental boundaries in egocentric coordinates. Nature communications, 10(1), [2772]. https://doi.org/10.1038/s41467-019-10722-y
- Hinman, J. R., Chapman, G. W., & Hasselmo, M. E. (2019). Neuronal representation of environmental boundaries in egocentric coordinates. Nature communications, 10(1), [2772]. https://doi.org/10.1038/s41467-019-10722-y
- inman JR, Chapman GW, Hasselmo ME (2019) Neuronal representation of environmental boundaries in egocentric coordinates. Nat Commun 10: 2772.
2018
- Alexander AS, Carstensen L, Hinman JR, Hasselmo ME (2018) Spatial correlates of the retrosplenial cortex during free exploration. iNav.
- Hinman JR, Chapman GW, Hasselmo ME (2018) Neuronal representation of environmental boundaries in egocentric coordinates. Soc. Neurosci. Absr.
- Hinman JR, Dannenberg H, Alexander AS, Hasselmo ME (2018) Neural mechanisms of navigation involving interactions of cortical and subcortical structures. J Neurophysiol 119: 2007 – 2029.
- Carstensen L, Alexander AS, Hinman JR, Hasselmo ME (2018) Spatial correlates of the retrosplenial cortex during free exploration. Soc. Neurosci. Absr.
- Hinman JR, Chapman GW, Hasselmo ME (2018) Egocentric representation of environmental boundaries in the striatum. iNav
- Hinman, J. R., Dannenberg, H., Alexander, A. S., & Hasselmo, M. E. (2018). Neural mechanisms of navigation involving interactions of cortical and subcortical structures. Journal of neurophysiology, 119(6), 2007-2029. https://doi.org/10.1152/jn.00498.2017
- Hinman, J. R., Dannenberg, H., Alexander, A. S., & Hasselmo, M. E. (2018). Neural mechanisms of navigation involving interactions of cortical and subcortical structures. Journal of neurophysiology, 119(6), 2007-2029. https://doi.org/10.1152/jn.00498.2017
- Rozeske RR, Wilson EK, Ajabi Z, Hinman JR, Brandon MP (2018) Egocentric boundary cell representation in the mouse dorsal medial striatum. iNav
2017
- Hasselmo ME, Hinman JR (2017) Marr’s influence on the standard model of hippocampus and the need for more theoretical advances. In: Vaina L, Passingham R (eds.) Computational Theories and their Implementation in the Brain: The Legacy of David Marr. Oxford University Press: Oxford, pp. 133 – 158.
- Hasselmo ME, Hinman JR, Dannenberg H, Stern C (2017) Models of spatial and temporal dimensions of memory. Curr Opin Behav Sci 17: 27 – 33.
- Hinman JR, Chapman GW, Hasselmo ME (2017) Egocentric representation of environmental boundaries in the striatum. Soc. Neurosci. Abstr.710.23.
- Hasselmo, M. E., & Hinman, J. R. (2017). Marr’s influence on the standard model of hippocampus, and the need for more theoretical advances. In Computational Theories and their Implementation in the Brain: The Legacy of David Marr (pp. 133-158). Oxford University Press. https://doi.org/10.1093/acprof:oso/9780198749783.003.0006
- Hasselmo, M. E., Hinman, J. R., Dannenberg, H., & Stern, C. E. (2017). Models of spatial and temporal dimensions of memory. Current Opinion in Behavioral Sciences, 17, 27-33. https://doi.org/10.1016/j.cobeha.2017.05.024
2016
- Dannenberg H, Hinman JR, Hasselmo ME (2016) Potential roles of cholinergic modulation in the neural coding of location and movement speed. J Physiol Paris 110: 52 – 64.
- Hasselmo ME, Hinman JR (2016) Computational Neuroscience: Hippocampus. In: Pfaff D, Volkow N (eds.) Neuroscience in the 21st century. Springer: New York, pp. 3081 – 3095.
- Hinman JR, Chapman GW, Hasselmo ME (2016) Representation of environmental boundaries within an egocentric reference frame. Soc. Neurosci. Abstr.359.13.
- Raudies F, Hinman JR, Hasselmo ME (2016) Modelling potential sensory influences on grid cells. J Physiol 594: 6513 – 6526.
- Hinman JR, Brandon MP, Chapman GW, Climer JR, Hasselmo ME (2016) Multiple running speed signals in medial entorhinal cortex. Neuron 91: 666 – 679.
- Hinman, J. R., Brandon, M. P., Climer, J. R., Chapman, G. W., & Hasselmo, M. E. (2016). Multiple Running Speed Signals in Medial Entorhinal Cortex. Neuron, 91(3), 666-679. https://doi.org/10.1016/j.neuron.2016.06.027
- Sabolek HR, Bunce JG, Penley SC, Hinman JR, Chrobak JJ (2006) Ketamine alters synchrony throughout the hippocampal formation. Soc. Neurosci. Abstr. 751.12
2015
- Climer JR, DiTullio R, Hinman JR, Hasselmo ME, Eden U (2015) Examining rhythmicity in extracellular recordings. Statistical Analysis of Neuronal Data 7.
- Jacobson TK, Schmidt B, Hinman JR, Escabí MA, Markus EJ (2015) Age-related decrease in theta and gamma coherence across dorsal CA1 pyramidale and radiatum layers. Hippocampus 25: 1327 – 1335.
- Schultheiss NW, Hinman JR, Hasselmo ME (2015) Models and theoretical frameworks for hippocampal and entorhinal cortex function in memory and navigation. In: Masami, T (ed.) Analysis and Modeling of coordinated multi-neuronal activity. Springer: New York, pp. 247-268.
- Hinman JR, Climer JR, Chapman GW, Hasselmo ME (2015) A novel slow (1-3 Hz) oscillatory cell type in the lateral septum. Soc. Neurosci. Abstr. 85.01.
2014
- Climer JR, DiTullio R, Hinman JR, Chapman GW, Brandon MP, Hasselmo ME, Eden U (2014) Addressing theta rhythmicity in extracellularly recorded neurons in rat and bat. Soc. Neurosci. Abstr. 465.06
- Long LL, Hinman JR, Chen C-M, Escabí MA, Chrobak JJ (2014) Theta dynamics in rat: speed and acceleration across the septotemporal axis. PLoS One 9:e97987.
- Long LL, Hinman JR, Chen C-M, Stevenson IH, Read HL, Escabí MA, Chrobak JJ (2014) Novel acoustic stimuli can alter locomotor speed to hippocampal theta relationship. Hippocampus 24: 1053 – 1058.
- Long LL, Norris AA, Hinman JR, Chen C-M, Stevenson IH, Read HL, Escabí MA, Chrobak JJ (2014) Novel acoustic stimuli can alter locomotor speed-theta relationship across the septotemporal axis of the hippocampus. Soc. Neurosci. Abstr. 751.08.
2013
- Hinman JR, Brandon MP, Chapman IV GW, Hasselmo ME (2013) Speed modulation of medial entorhinal cortical neurons during medial septal inactivation. Soc. Neurosci. Abstr. 769.01.
- Hinman JR, Penley SC, Escabí MA, Chrobak JJ (2013) Ketamine disrupts theta synchrony across the septotemporal axis of the CA1 region of hippocampus. J Neurophysiol 109: 570 – 579.
- Penley SC, Hinman JR, Long LL, Markus EJ, Escabí MA, Chrobak JJ (2013) Novel space alters theta and gamma local field potentials across the septotemporal axis of the rodent hippocampus. Front Syst Neurosci 7: 20.
- Schmidt B, Hinman JR, Jacobson T, Szkudlarek E, Argraves M, Escabí MA, Markus EJ (2013) Dissociation between dorsal and ventral theta oscillations during a place and response task. J Neurosci 33: 6212 – 6224.
- Jacobson T, Howe MD, Schmidt B, Hinman JR, Escabí MA, Markus EJ (2013) Hippocampal theta, gamma and theta-gamma coupling: Effects of aging, environmental change and cholinergic activation. J Neurophysiol 109: 1852 – 1865.
2012
- Chrobak JJ, Long LL, Escabí MA, Hinman JR (2012) Theta dynamics: septotemporal differences in response to habituation, spatial novelty and the absence of expected reward. Soc. Neurosci. Abstr. 918.18.
- Hinman JR, Long LL, Escabí MA, Chrobak JJ (2012) Theta dynamics: the relationship between theta frequency and locomotor speed in familiar and novel environments. Soc. Neurosci. Abstr. 918.17
- Long LL, Hinman JR, Escabí MA, Chrobak JJ (2012) Theta dynamics: speed, velocity acceleration and contribution to cognition. Soc. Neurosci. Abstr. 918.17.
- Penley SC, Hinman JR, Sabolek HR, Escabí MA, Markus EJ, Chrobak JJ (2012) Theta and gamma coherence across the septotemporal axis during distinct behavioral states. Hippocampus 22: 1164 – 1175.
2011
- Collins-Praino LE, Paul NE, Rychalsky K, Hinman JR, Chrobak JJ, Senatus PB and Salamone JD (2011). Pharmacological and physiological characterization of the tremulous jaw movement model, a rodent model of parkinsonian tremor: Potential insights into the pathophysiology of tremor. Front Syst Neurosci 5: 49.
- Hinman JR, Penley SC, Long LL, Escabí MA, Chrobak JJ (2011) Septotemporal variation in dynamics of theta: speed and habituation. J Neurophysiol 105: 2675 – 2686.
- Schmidt B, Argraves M, Szkudlarek E, Hinman JR, Jacobson TK, Escabí MA, Markus EJ (2011) Thetagamma modulation along the septotemporal axis during a place and response task. Soc. Neurosci. Abstr. 938.10.
- Szalkowski CE, Hinman JR, Threlkeld SW, Wang Y, LePack A, Rosen GD, Chrobak JJ, LoTurco JJ, Fitch RH (2011) Persistent spatial working memory deficits in rats following in utero RNAi of Dyx1c1. Genes, Brain and Behavior 10: 244 – 252.
- Corriveau JA, Hinman JR, Larossa C, Salamone J, Chrobak JJ (2011) “Episodic” memory in the rat: the “short” and “long” retention of a trial-unique, delayed conditional discrimination following NMDA antagonist treatment. Soc. Neurosci. Abstr. 938.13.
- Hinman JR, Penley SC, Escabí MA, Chrobak JJ (2011) Ketamine induced disruption in global theta coherence across the septotemporal axis of the hippocampus. Soc. Neurosci. Abstr. 938.15.
- Jacobson TK, Howe MD, Schmidt B, Hinman JR, Bohannon S, Mastro K, Escabí MA, Markus EJ (2011) Hippocampal oscillations in young and aged rats: Response to altered environments. Soc. Neurosci. Abstr. 938.20
- Long LL, Hinman JR, Penley SC, Escabí MA, Chrobak JJ (2011) Septotemporal variations in hippocampal theta and other oscillations during REM sleep. Soc. Neurosci. Abstr. 938.14.
2010
- Collins LE, Galtieri DJ, Brennum LT, Sager TN, Hockemeyer J, Müller CE, Hinman JR, Chrobak JJ, Salamone JD (2010) Oral tremor induced by the muscarinic agonist pilocarpine is suppressed by the adenosine A2A antagonist MSX-3 and SCH58261, but not the adenosine A1 antagonist DPCPX. Pharmacol Biochem Behav 94: 561 – 569.
- Long LL, Hinman JR, Penley SC, Escabí MA, Chrobak JJ (2010) Theta/gamma cross frequency coupling across the septotemporal axis of the hippocampus and the effects of ketamine. Soc. Neurosci. Abstr. 203.1.
- Hinman JR, Penley SC, Long LL, Escabí MA, Chrobak JJ (2010) Septotemporal variation in the effects of speed on the theta rhythm. Soc. Neurosci. Abstr. 203.2.
2009
- Hinman JR, Penley SC, Escabí MA, Chrobak JJ (2009) Septotemporal variation in the speed modulation of theta power. Winter Conf Neurobiol Learn Mem
- Sabolek HR, Penley SC, Hinman JR, Bunce JG, Markus EJ, Escabí MA, Chrobak JJ (2009) Theta and gamma coherence along the septotemporal axis of the hippocampus. J Neurophysiol 101:1192 – 1200.
- Penley SC, Hinman JR, Escabí MA, Markus EJ, Chrobak JJ (2009) Salience of environmental novelty: Theta power, frequency and coherence within the hippocampus and entorhinal cortex. Soc. Neurosci. Abstr. 192.28.
2008
- Chrobak JJ, Hinman JR (2008) Episodic memory, proactive interference and ketamine induced cognitive deficits in the rat. Soc. Neurosci. Abstr. 879.1.
- Hinman JR, Penley SC, Escabí MA, Chrobak JJ (2008) Theta/Gamma synchronization: the effects of the NMDA antagonist ketamine. Soc. Neurosci. Abstr. 879.2.
- Penley SC, Hinman JR, Escabí MA, Markus EJ, Chrobak JJ (2008) The effects of novelty and aging on the coherence of theta and gamma in the hippocampus and entorhinal cortex. Soc. Neurosci. Abstr. 879.3.
- Schmidt B, Hinman JR, Penley SC, Jacobson TK, Ciurylo E, Zhang E, Escabí MA, Markus EJ (2008) Local field potentials in the hippocampus, striatum and nucleus accumbens during a place and response task. Soc. Neurosci. Abstr. 389.3.
- Cleary CE, Hinman JR, DiPinto K, Malloy D, Threlkeld SW, Wang Y, Rosen GD, Chrobak JJ, Fitch RH (2008) Assessment of episodic memory performance following early interference with a dyslexia risk gene (Dyx1c1) in male Sprague-Dawley rats. Soc. Neurosci. Abstr. 249.3.
- man JR, Sabolek HR (2008) Revealing past memories: proactive interference and ketamineinduced memory deficits. J Neurosci 28: 4512 – 4520.
2007
- Hinman JR, Sabolek HR, Chrobak JJ (2007) Ketamine induced proactive interference between working and episodic memories in the rat: relation to hippocampal theta. Soc. Neurosci. Abstr. 305.8.
- Schmidt B, Penley SC, Hinman JR, Jacobson TK, Fairchild J, Gruenbaum B, Escabí MA, Markus EJ (2007) Oscillations of local field potentials in the rat dorsal hippocampus, dorsal striatum, and nucleus accumbens: Comparing place and response trials. Soc. Neurosci. Abstr. 640.7.
2006
- Hinman JR, Brandon MP, Sava S, Markus EJ (2006) Examining the orthogonality of hippocampal place cells across environments. Soc. Neurosci. Abstr. 371.2.