Directory

Jefferson Chan's directory photo.

Jefferson Chan

Associate Professor

Primary Affiliation

Photoacoustic Imaging

Affiliations

Status Part-time Faculty

Home Department of Chemistry

Phone 244-8272

Email jeffchan@illinois.edu

Address 4065 Beckman Institute, 405 North Mathews Avenue

  • Biography

    Professor Chan is an associate professor in the Department of Chemistry. His graduate work was recognized with the Boehringer Ingelheim Doctoral Research Award for the top Canadian thesis in the areas of organic and bioorganic chemistry. From 2011 to 2014 he was a Human Frontiers Science Program postdoctoral fellow at the University of California, Berkeley with Christopher Chang. He began his independent career at the University of Illinois, Urbana-Champaign in 2014.

    Education

    • B.Sc., chemistry, University of British Columbia, 2006
    • Ph.D., Simon Fraser University, 2011
  • Honors

    • 2022: School of Chemical Sciences Teaching Award

    • 2022: Camille Dreyfus Teacher-Scholar Award

    • 2021: Helen Corley Petit Scholar

    • 2021: Teachers Ranked as Excellent

    • 2020: Teachers Ranked as Excellent

    • 2019: Beckman Fellow Award

    • 2018: Thieme Chemistry Journal Award

    • 2018: Center for Advanced Study Fellowship

    • 2018: NSF CAREER Award

    • 2018: Research Corporation Scialog Fellow

    • 2017: Alfred P. Sloan Foundation Fellowship

  • Research

    Research interests:

    • Complex molecule synthesis

    • Chemical biology

    • Analyte-responsive imaging agents

    • Drug delivery platforms

    Professor Chan is currently working on the development of responsive imaging agents known as activity-based sensing probes. He uses a unique approach to detect a specific disease biomarker or biological analyte of interest known as activity-based sensing. In contrast to traditional binding-based approaches (e.g., appending an imaging agent to an antibody that targets a protein), he leverages unique chemistry of the target analyte for sensing. This approach allows him to tune the reactivity of his probes to detect fleeting species by accelerating the reaction or to attenuate reaction rates for biomarkers that are highly abundant. Chan has also coupled sensing to a variety of imaging modalities including fluorescence, bioluminescence, and photoacoustic imaging. He has used the chemical tools for diagnostic applications such as the development of a photoacoustic imaging-based companion diagnostic agent for cancer and a biopsy-free assessment method for elevated hepatic copper in Wilson’s disease. His goal is to expand his activity-based sensing design approach to developing probes for other imaging modalities including ultrasound, PET, SPECT, and MRI.

  • 2024

    • Activity-Based Nitric Oxide-Responsive Porphyrin for Site-Selective and Nascent Cancer Ablation Bandyopadhyay, S., Zhao, Z., East, A. K., Hernandez, R. T., Forzano, J. A., Shapiro, B. A., Yadav, A. K., Swartchick, C. B. and Chan, J., Feb 28 2024, In: ACS Applied Materials and Interfaces. 16, 8, p. 9680-9689 10 p.
    • Optical imaging probes for selective detection of butyrylcholinesterase Dirak, M., Chan, J. and Kolemen, S., Feb 7 2024, In: Journal of Materials Chemistry B. 12, 5, p. 1149-1167 19 p.

    2023

    • Activity-based bioluminescence probes for in vivo sensing applications Yadav, A. K. and Chan, J., Jun 2023, In: Current Opinion in Chemical Biology. 74, 102310.
    • Activity-Based Photoacoustic Probes for Detection of Disease Biomarkers beyond Oncology Lee, M. C., Landers, K. and Chan, J., Jun 21 2023, In: ACS Bio and Med Chem Au. 3, 3, p. 223-232 10 p.
    • Application of AlDeSense to Stratify Ovarian Cancer Cells Based on Aldehyde Dehydrogenase 1A1 Activity Lee, M. C., Gardner, S. H., Tapia Hernandez, R. and Chan, J., Mar 31 2023, In: Journal of visualized experiments : JoVE. 193
    • Biomimetic Approach to Promote Cellular Uptake and Enhance Photoacoustic Properties of Tumor-Seeking Dyes East, A. K., Lee, M. C., Jiang, C., Sikander, Q. and Chan, J., Apr 5 2023, In: Journal of the American Chemical Society. 145, 13, p. 7313-7322 10 p.
    • Comparison of a Minimally Invasive Transthoracic Approach and a Surgical Method for Intrapleural Injection of Tumor Cells in Mice Xu, J. J., Lucero, M. Y., Herndon, N. L., Lee, M. C. and Chan, J., Apr 2023, In: Comparative Medicine. 73, 2, p. 120-126 7 p.
    • Development of Nitroreductase-Activatable Fluoroquinolone Prodrugs Exhibiting Attenuated Magnesium Ion Binding Zhao, Z., Yadav, A. K., Weng, Y. and Chan, J., Oct 2023, In: Helvetica Chimica Acta. 106, 10, e202300100.
    • Hydrolysis-Resistant Ester-Based Linkers for Development of Activity-Based NIR Bioluminescence Probes Yadav, A. K., Zhao, Z., Weng, Y., Gardner, S. H., Brady, C. J., Pichardo Peguero, O. D. and Chan, J., Jan 18 2023, In: Journal of the American Chemical Society. 145, 2, p. 1460-1469 10 p.
    • Leveraging coordination chemistry to visualize metal ions via photoacoustic imaging Swartchick, C. B. and Chan, J., Jun 2023, In: Current Opinion in Chemical Biology. 74, 102312.
    • Leveraging intracellular ALDH1A1 activity for selective cancer stem-like cell labeling and targeted treatment via in vivo click reaction Bo, Y., Zhou, J., Cai, K., Wang, Y., Feng, Y., Li, W., Jiang, Y., Kuo, S. H., Roy, J., Anorma, C., Gardner, S. H., Luu, L. M., Lau, G. W., Bao, Y., Chan, J., Wang, H. and Cheng, J., Sep 5 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 36, e2302342120.
    • Xanthene-Based Nitric Oxide-Responsive Nanosensor for Photoacoustic Imaging in the SWIR Window Rathnamalala, C. S. L., Hernandez, S., Lucero, M. Y., Swartchick, C. B., Kalam Shaik, A., Hammer, N. I., East, A. K., Gwaltney, S. R., Chan, J. and Scott, C. N., Mar 20 2023, In: Angewandte Chemie - International Edition. 62, 13, e202214855.

    2022

    • Activity-Based NIR Bioluminescence Probe Enables Discovery of Diet-Induced Modulation of the Tumor Microenvironment via Nitric Oxide Yadav, A. K., Lee, M. C., Lucero, M. Y., Su, S., Reinhardt, C. J. and Chan, J., Apr 27 2022, In: ACS Central Science. 8, 4, p. 461-472 12 p.
    • Activity-based Photoacoustic Probes Reveal Elevated Intestinal MGL and FAAH Activity in a Murine Model of Obesity Lucero, M. Y., Gardner, S. H., Yadav, A. K., Borri, A., Zhao, Z. and Chan, J., Nov 2 2022, In: Angewandte Chemie - International Edition. 61, 44, e202211774.
    • Bioreducible N-oxide-based probes for imaging of hypoxia Chan, J. K. F. (Inventor) and Knox, H. J. (Inventor), Apr 5 2022, U.S. Patent No. 11292803, Aug 20 2019
    • Repurposing Cyanine Photoinstability To Develop Near-Infrared Light-Activatable Nanogels for In Vivo Cargo Delivery Tapia Hernandez, R., Lee, M. C., Yadav, A. K. and Chan, J., Oct 5 2022, In: Journal of the American Chemical Society. 144, 39, p. 18101-18108 8 p.
    • Selective Fluorescent Probe For Aldehyde Dehydrogenase Chan, J. K. F. (Inventor), Anorma, C. D. (Inventor) and Bearrood, T. E. (Inventor), Aug 9 2022, U.S. Patent No. 11407725
    • Stable, Bright, and Long-Fluorescence-Lifetime Dyes for Deep-Near-Infrared Bioimaging Li, J., Dong, Y., Wei, R., Jiang, G., Yao, C., Lv, M., Wu, Y., Gardner, S. H., Zhang, F., Lucero, M. Y., Huang, J., Chen, H., Ge, G., Chan, J., Chen, J., Sun, H., Luo, X., Qian, X. and Yang, Y., Aug 10 2022, In: Journal of the American Chemical Society. 144, 31, p. 14351-14362 12 p.
    • Synthesis of Silicon-Substituted Hemicyanines for Multimodal SWIR Imaging East, A. K., Lee, M. C., Smaga, L. P., Jiang, C., Mallojjala, S. C., Hirschi, J. S. and Chan, J., Nov 25 2022, In: Organic Letters. 24, 46, p. 8509-8513 5 p.
    • Targeted contrast agents and activatable probes for photoacoustic imaging of cancer Zhao, Z., Swartchick, C. B. and Chan, J., Feb 7 2022, In: Chemical Society Reviews. 51, 3, p. 829-868 40 p.
    • Thiol-based fluorescent probe for reactive species Chan, J. K. F. (Inventor) and Pino, N. W. (Inventor), May 24 2022, U.S. Patent No. 11339175, Nov 6 2019

    2021

    • A General Approach to Convert Hemicyanine Dyes into Highly Optimized Photoacoustic Scaffolds for Analyte Sensing** Gardner, S. H., Brady, C. J., Keeton, C., Yadav, A. K., Mallojjala, S. C., Lucero, M. Y., Su, S., Yu, Z., Hirschi, J. S., Mirica, L. M. and Chan, J., Aug 16 2021, In: Angewandte Chemie - International Edition. 60, 34, p. 18860-18866 7 p.
    • A General Strategy to Optimize the Performance of aza-BODIPY-based Probes for Enhanced Photoacoustic Properties Yadav, A. K., Tapia Hernandez, R. and Chan, J., 2021, Photoacoustic Probes for In Vivo Imaging. Chan, J. (ed.). Academic Press Inc., p. 415-441 27 p. (Methods in Enzymology; vol. 657).
    • Acoustogenic Probes: A Demonstration to Introduce the Photoacoustic Effect via Analyte Sensing Tapia Hernandez, R., Forzano, J. A., Lucero, M. Y., Anorma, C. and Chan, J., Aug 10 2021, In: Journal of Chemical Education. 98, 8, p. 2618-2624 7 p.
    • Activity-based Photoacoustic Probe for Biopsy-free Assessment of Copper in Murine Models of Wilson's Disease and Liver Metastasis Lucero, M. Y., Tang, Y., Zhang, C. J., Su, S., Forzano, J. A., Garcia, V., Huang, X., Moreno, D. and Chan, J., Sep 7 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 36
    • Advances in Activity-Based Sensing Probes for Isoform-Selective Imaging of Enzymatic Activity Gardner, S. H., Reinhardt, C. J. and Chan, J., Mar 1 2021, In: Angewandte Chemie - International Edition. 60, 10, p. 5000-5009 10 p.
    • Development of NIR-II Photoacoustic Probes Tailored for Deep-Tissue Sensing of Nitric Oxide Lucero, M. Y., East, A. K., Reinhardt, C. J., Sedgwick, A. C., Su, S., Lee, M. C. and Chan, J., May 12 2021, In: Journal of the American Chemical Society. 143, 18, p. 7196-7202 7 p.
    • Near-infrared II Photoacoustic Probes for Nitric Oxide Sensing Lucero, M. Y., East, A. K. and Chan, J., 2021, Photoacoustic Probes for In Vivo Imaging. Chan, J. (ed.). Academic Press Inc., p. 157-180 24 p. (Methods in Enzymology; vol. 657).
    • New directions of activity-based sensing forin vivoNIR imaging East, A. K., Lucero, M. Y. and Chan, J., Mar 14 2021, In: Chemical Science. 12, 10, p. 3393-3405 13 p.
    • Photoacoustic imaging of elevated glutathione in models of lung cancer for companion diagnostic applications Lucero, M. Y. and Chan, J., Dec 2021, In: Nature Chemistry. 13, 12, p. 1248-1256 9 p.
    • Photoacoustic Probes for In Vivo Imaging Chan, J. K. F. (Editor), 2021, Academic Press Inc. 502 p. (Methods in Enzymology; vol. 657)
    • Thienylpiperidine Donor NIR Xanthene-Based Dye for Photoacoustic Imaging Rathnamalala, C. S. L., Pino, N. W., Herring, B. S., Hooper, M., Gwaltney, S. R., Chan, J. and Scott, C. N., Oct 1 2021, In: Organic Letters. 23, 19, p. 7640-7644 5 p.

    2020

    • A Photoactivatable Formaldehyde Donor with Fluorescence Monitoring Reveals Threshold to Arrest Cell Migration Smaga, L. P., Pino, N. W., Ibarra, G. E., Krishnamurthy, V. and Chan, J., Jan 15 2020, In: Journal of the American Chemical Society. 142, 2, p. 680-684 5 p.
    • Acoustic-based chemical tools for profiling the tumor microenvironment Yadav, A. K., Hernandez, S., Su, S. and Chan, J., Aug 2020, In: Current Opinion in Chemical Biology. 57, p. 114-121 8 p.
    • Activity-Based Sensing of Ascorbate by Using Copper-Mediated Oxidative Bond Cleavage Yu, Z. H., Reinhardt, C. J., Wong, T. H. F., Tong, K. Y., Chan, J. and Au-Yeung, H. Y., Jul 17 2020, In: Chemistry - A European Journal. 26, 40, p. 8794-8800 7 p.
    • An Activity-Based Sensing Approach for the Detection of Cyclooxygenase-2 in Live Cells Yadav, A. K., Reinhardt, C. J., Arango, A. S., Huff, H. C., Dong, L., Malkowski, M. G., Das, A., Tajkhorshid, E. and Chan, J., Feb 17 2020, In: Angewandte Chemie - International Edition. 59, 8, p. 3307-3314 8 p.
    • Imaging the landmarks of vascular recovery Hedhli, J., Kim, M. W., Knox, H. J., Cole, J. A., Huynh, T., Schuelke, M., Dobrucki, I. T., Kalinowski, L., Chan, J., Sinusas, A. J., Insana, M. F. and Dobrucki, L. W., 2020, In: Theranostics. 10, 4, p. 1733-1745 13 p.
    • Near-infrared photoactivatable nitric oxide donors with photoacoustic readout Zhou, E. Y., Knox, H. J., Reinhardt, C. J., Partipilo, G. and Chan, J., 2020, Chemical Tools for Imaging, Manipulating, and Tracking Biological Systems: Diverse Chemical, Optical and Bioorthogonal Methods. Chenoweth, D. M. (ed.). Academic Press Inc., p. 113-147 35 p. (Methods in Enzymology; vol. 641).
    • Nitric oxide imaging in cancer enabled by steric relaxation of a photoacoustic probe platform Reinhardt, C. J., Xu, R. and Chan, J., Feb 14 2020, In: Chemical Science. 11, 6, p. 1587-1592 6 p.
    • Rational Design of a Red Fluorescent Sensor for ALDH1A1 Displaying Enhanced Cellular Uptake and Reactivity Bearrood, T. E., Aguirre-Figueroa, G. and Chan, J., Feb 19 2020, In: Bioconjugate Chemistry. 31, 2, p. 224-228 5 p.

    2019

    • A Conformationally Restricted Aza-BODIPY Platform for Stimulus-Responsive Probes with Enhanced Photoacoustic Properties Zhou, E. Y., Knox, H. J., Liu, C., Zhao, W. and Chan, J., Nov 6 2019, In: Journal of the American Chemical Society. 141, 44, p. 17601-17609 9 p.
    • A Conformationally Restricted Aza-BODIPY Platform for Stimulus-Responsive Probes with Enhanced Photoacoustic Properties Zhou, E. Y., Knox, H. J., Liu, C., Zhao, W. and Chan, J., Nov 6 2019, In: Journal of the American Chemical Society. 141, 44, p. 17601-17609 9 p.
    • Biodegradable Biliverdin Nanoparticles for Efficient Photoacoustic Imaging Fathi, P., Knox, H. J., Sar, D., Tripathi, I., Ostadhossein, F., Misra, S. K., Esch, M. B., Chan, J. and Pan, D., Jul 23 2019, In: ACS Nano. 13, 7, p. 7690-7704 15 p.
    • Simultaneous photoacoustic imaging of intravascular and tissue oxygenation Chen, M., Knox, H. J., Tang, Y., Liu, W., Nie, L., Chan, J. and Yao, J., Aug 1 2019, In: Optics Letters. 44, 15, p. 3773-3776 4 p.

    2018

    • A Ratiometric Acoustogenic Probe for in Vivo Imaging of Endogenous Nitric Oxide Reinhardt, C. J., Zhou, E. Y., Jorgensen, M. D., Partipilo, G. and Chan, J., Jan 24 2018, In: Journal of the American Chemical Society. 140, 3, p. 1011-1018 8 p.
    • Acoustogenic Probes: A New Frontier in Photoacoustic Imaging Knox, H. J. and Chan, J., Nov 20 2018, In: Accounts of chemical research. 51, 11, p. 2897-2905 9 p.
    • Copper regulates rest-activity cycles through the locus coeruleus-norepinephrine system Xiao, T., Ackerman, C. M., Carroll, E. C., Jia, S., Hoagland, A., Chan, J., Thai, B., Liu, C. S., Isacoff, E. Y. and Chang, C. J., Jul 1 2018, In: Nature chemical biology. 14, 7, p. 655-663 9 p.
    • Damage-Responsive Microcapsules for Amplified Photoacoustic Detection of Microcracks in Polymers Geng, J. L., Li, W., Smaga, L. P., Sottos, N. R. and Chan, J., Apr 10 2018, In: Chemistry of Materials. 30, 7, p. 2198-2202 5 p.
    • Development of Photoacoustic Probes for in Vivo Molecular Imaging Reinhardt, C. J. and Chan, J., Jan 16 2018, In: Biochemistry. 57, 2, p. 194-199 6 p.
    • Near-Infrared Photoactivatable Nitric Oxide Donors with Integrated Photoacoustic Monitoring Zhou, E. Y., Knox, H. J., Reinhardt, C. J., Partipilo, G., Nilges, M. J. and Chan, J., Sep 19 2018, In: Journal of the American Chemical Society. 140, 37, p. 11686-11697 12 p.
    • Photophysical Tuning of N-Oxide-Based Probes Enables Ratiometric Photoacoustic Imaging of Tumor Hypoxia Knox, H. J., Kim, T. W., Zhu, Z. and Chan, J., Jul 20 2018, In: ACS chemical biology. 13, 7, p. 1838-1843 6 p.
    • Surveillance of Cancer Stem Cell Plasticity Using an Isoform-Selective Fluorescent Probe for Aldehyde Dehydrogenase 1A1 Anorma, C., Hedhli, J., Bearrood, T. E., Pino, N. W., Gardner, S. H., Inaba, H., Zhang, P., Li, Y., Feng, D., Dibrell, S. E., Kilian, K. A., Dobrucki, L. W., Fan, T. M. and Chan, J., Aug 22 2018, In: ACS Central Science. 4, 8, p. 1045-1055 11 p.

    2017

    • A bioreducible N-oxide-based probe for photoacoustic imaging of hypoxia Knox, H. J., Hedhli, J., Kim, T. W., Khalili, K., Dobrucki, L. W. and Chan, J., Dec 1 2017, In: Nature communications. 8, 1, 1794.
    • Bright Dyes Bring Biology into Focus Yadav, A. K. and Chan, J., Sep 27 2017, In: ACS Central Science. 3, 9, p. 920-921 2 p.
    • Disproportionate impact of named reactions on chemical biology Bearrood, T. E. and Chan, J., 2017, In: Aldrichimica Acta. 50, 2, p. 31-41 11 p.
    • DNA Aptamer-Based Activatable Probes for Photoacoustic Imaging in Living Mice Zhang, J., Smaga, L. P., Satyavolu, N. S. R., Chan, J. and Lu, Y., Dec 6 2017, In: Journal of the American Chemical Society. 139, 48, p. 17225-17228 4 p.
    • Host and pathogen copper-transporting P-type ATPases function antagonistically during Salmonella infection Ladomersky, E., Khan, A., Shanbhag, V., Cavet, J. S., Chan, J., Weisman, G. A. and Petris, M. J., Sep 1 2017, In: Infection and immunity. 85, 9, e00351-17.
    • NitroxylFluor: A Thiol-Based Fluorescent Probe for Live-Cell Imaging of Nitroxyl Pino, N. W., Davis, J., Yu, Z. and Chan, J., Dec 27 2017, In: Journal of the American Chemical Society. 139, 51, p. 18476-18479 4 p.
    • The intestinal copper exporter CUA-1 is required for systemic copper homeostasis in Caenorhabditis elegans Chun, H., Sharma, A. K., Lee, J., Chan, J., Jia, S. and Kim, B. E., Jan 6 2017, In: Journal of Biological Chemistry. 292, 1, p. 1-14 14 p.

    2016

    • Copper regulates cyclic-AMP-dependent lipolysis Krishnamoorthy, L., Cotruvo, J. A., Chan, J., Kaluarachchi, H., Muchenditsi, A., Pendyala, V. S., Jia, S., Aron, A. T., Ackerman, C. M., Wal, M. N. V., Guan, T., Smaga, L. P., Farhi, S. L., New, E. J., Lutsenko, S. and Chang, C. J., Aug 1 2016, In: Nature chemical biology. 12, 8, p. 586-592 7 p.

    2015

    • A Reaction-Based Fluorescent Probe for Imaging of Formaldehyde in Living Cells Roth, A., Li, H., Anorma, C. and Chan, J., Sep 2 2015, In: Journal of the American Chemical Society. 137, 34, p. 10890-10893 4 p.
    • Disease modeling and gene therapy of copper storage disease in canine hepatic organoids Nantasanti, S., Spee, B., Kruitwagen, H. S., Chen, C., Geijsen, N., Oosterhoff, L. A., Van Wolferen, M. E., Pelaez, N., Fieten, H., Wubbolts, R. W., Grinwis, G. C., Chan, J., Huch, M., Vries, R. R. G., Clevers, H., De Bruin, A., Rothuizen, J., Penning, L. C. and Schotanus, B. A., Nov 10 2015, In: Stem Cell Reports. 5, 5, p. 895-907 13 p.
    • Photoacoustic Probes for Ratiometric Imaging of Copper(II) Li, H., Zhang, P., Smaga, L. P., Hoffman, R. A. and Chan, J., Dec 23 2015, In: Journal of the American Chemical Society. 137, 50, p. 15628-15631 4 p.

    2014

    • Copper is an endogenous modulator of neural circuit spontaneous activity Dodani, S. C., Firl, A., Chan, J., Nam, C. I., Aron, A. T., Onak, C. S., Ramos-Torres, K. M., Paek, J., Webster, C. M., Feller, M. B. and Chang, C. J., Nov 18 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 46, p. 16280-16285 6 p.
    • Copper transporter 2 regulates intracellular copper and sensitivity to cisplatin Huang, C. P., Fofana, M., Chan, J., Chang, C. J. and Howell, S. B., Mar 2014, In: Metallomics. 6, 3, p. 654-661 8 p.
    • Making light of stress Chan, J. and Chang, C. J., Apr 2014, In: Nature Biotechnology. 32, 4, p. 337-338 2 p.
    • Peptidoglycan Recognition Proteins Kill Bacteria by Inducing Oxidative, Thiol, and Metal Stress Kashyap, D. R., Rompca, A., Gaballa, A., Helmann, J. D., Chan, J., Chang, C. J., Hozo, I., Gupta, D. and Dziarski, R., Jul 2014, In: PLoS pathogens. 10, 7, e1004280.
    • Subcellular metal imaging identifies dynamic sites of Cu accumulation in Chlamydomonas Hong-Hermesdorf, A., Miethke, M., Gallaher, S. D., Kropat, J., Dodani, S. C., Chan, J., Barupala, D., Domaille, D. W., Shirasaki, D. I., Loo, J. A., Weber, P. K., Pett-Ridge, J., Stemmler, T. L., Chang, C. J. and Merchant, S. S., Dec 1 2014, In: Nature chemical biology. 10, 12, p. 1034-1042 9 p.
    • The multiple antibiotic resistance regulator MarR is a copper sensor in Escherichia coli Hao, Z., Lou, H., Zhu, R., Zhu, J., Zhang, D., Zhao, B. S., Zeng, S., Chen, X., Chan, J., He, C. and Chen, P. R., Jan 2014, In: Nature chemical biology. 10, 1, p. 21-28 8 p.
    • Transition-state structure for the hydronium-ion-promoted hydrolysis of ±- d -glucopyranosyl fluoride Chan, J., Tang, A. and Bennet, A. J., 2014, In: Canadian Journal of Chemistry. 93, 4, p. 463-467 5 p.
    • Transition-state structure for the quintessential SN2 reaction of a carbohydrate: Reaction of a-glucopyranosyl fluoride with azide ion in Water Chan, J., Sannikova, N., Tang, A. and Bennet, A. J., Sep 3 2014, In: Journal of the American Chemical Society. 136, 35, p. 12225-12228 4 p.
    • Wilson Disease Protein ATP7B Utilizes Lysosomal Exocytosis to Maintain Copper Homeostasis Polishchuk, E. V., Concilli, M., Iacobacci, S., Chesi, G., Pastore, N., Piccolo, P., Paladino, S., Baldantoni, D., vanIJzendoorn, S. C. D., Chan, J., Chang, C. J., Amoresano, A., Pane, F., Pucci, P., Tarallo, A., Parenti, G., Brunetti-Pierri, N., Settembre, C., Ballabio, A. and Polishchuk, R. S., Jun 23 2014, In: Developmental cell. 29, 6, p. 686-700 15 p.

    2013

    • Molecular imaging of labile iron(II) pools in living cells with a turn-on fluorescent probe Au-Yeung, H. Y., Chan, J., Chantarojsiri, T. and Chang, C. J., Oct 9 2013, In: Journal of the American Chemical Society. 135, 40, p. 15165-15173 9 p.

    2012

    • A stepwise solvent-promoted S Ni reaction of a-d- glucopyranosyl fluoride: Mechanistic implications for retaining glycosyltransferases Chan, J., Tang, A. and Bennet, A. J., Jan 18 2012, In: Journal of the American Chemical Society. 134, 2, p. 1212-1220 9 p.
    • Bacterial and viral sialidases: Contribution of the conserved active site glutamate to catalysis Chan, J., Watson, J. N., Lu, A., Cerda, V. C., Borgford, T. J. and Bennet, A. J., Jan 10 2012, In: Biochemistry. 51, 1, p. 433-441 9 p.
    • Enzymology of influenza virus sialidase Chan, J. and Bennet, A. J., 2012, Influenza Virus Sialidase - A Drug Discovery Target. Itzstein, M. V. (ed.). Springer, p. 47-66 20 p. (Milestones in Drug Therapy; vol. 36).
    • Metabolism of vertebrate amino sugars with N-glycolyl groups: Intracellular ß-O-linked N-glycolylglucosamine (GlcNGc), UDP-GlcNGc,and the biochemical and structural rationale for the substrate tolerance of ß-O-linked& beta;-N-acetylglucosaminidase Macauley, M. S., Chan, J., Zandberg, W. F., He, Y., Whitworth, G. E., Stubbs, K. A., Yuzwa, S. A., Bennet, A. J., Varki, A., Davies, G. J. and Vocadlo, D. J., Aug 17 2012, In: Journal of Biological Chemistry. 287, 34, p. 28882-28897 16 p.
    • Reaction-based small-molecule fluorescent probes for chemoselective bioimaging Chan, J., Dodani, S. C. and Chang, C. J., Dec 2012, In: Nature Chemistry. 4, 12, p. 973-984 12 p.
    • Transition state analysis of Vibrio cholerae sialidase-catalyzed hydrolyses of natural substrate analogues Chan, J., Lewis, A. R., Indurugalla, D., Schur, M., Wakarchuk, W. and Bennet, A. J., Feb 29 2012, In: Journal of the American Chemical Society. 134, 8, p. 3748-3757 10 p.

    2011

    • A mechanistic study of sialic acid mutarotation: Implications for mutarotase enzymes Chan, J., Sandhu, G. and Bennet, A. J., Jul 7 2011, In: Organic and Biomolecular Chemistry. 9, 13, p. 4818-4822 5 p.
    • The Aspergillus fumigatus sialidase is a 3-deoxy-D-glycero-D-galacto-2- nonulosonic acid hydrolase (KDNase): Structural and mechanistic insights Telford, J. C., Yeung, J. H. F., Xu, G., Kiefel, M. J., Watts, A. G., Hader, S., Chan, J., Bennet, A. J., Moore, M. M. and Taylor, G. L., Mar 25 2011, In: Journal of Biological Chemistry. 286, 12, p. 10783-10792 10 p.
    • Turnover Is rate-limited by deglycosylation for micromonospora viridifaciens sialidase-catalyzed hydrolyses: Conformational implications for the Michaelis complex Chan, J., Lu, A. and Bennet, A. J., Mar 9 2011, In: Journal of the American Chemical Society. 133, 9, p. 2989-2997 9 p.

    2010

    • A direct NMR method for the measurement of competitive kinetic isotope effects Chan, J., Lewis, A. R., Gilbert, M., Karwaski, M. F. and Bennet, A. J., Jun 2010, In: Nature chemical biology. 6, 6, p. 405-407 3 p.