
Wawrzyniec Dobrucki
Associate Professor
Primary Affiliation
Multimodal Vascular ImagingAffiliations
Status Full-time Faculty
Home Department of Bioengineering
Phone 244-3938
Email dobrucki@illinois.edu
Address 4261 Beckman Institute, 405 North Mathews Avenue
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Biography
Wawrzyniec (Wawosz) Lawrence Dobrucki is an associate professor and director of Professional Master's program in the Department of Bioengineering with affiliations in the Carle Illinois College of Medicine and the Carle R. Woese Institute for Genomic Biology at the University of Illinois at Urbana-Champaign, as well as the Medical University of Gdansk in Poland. He holds a full-time faculty position at the Beckman Institute for Advanced Science and Technology, where he serves as co-chair for the Integrative Imaging Theme and directs the Experimental Molecular Imaging Laboratory (EMIL).
Prof. Dobrucki is also involved in translational bioimaging utilizing his 15-plus years’ experience in the development and validation of novel SPECT/PET radiotracers and multimodal multifunctional contrast agents. He is an active member of the Preclinical Imaging Task Force at the Society of Nuclear Medicine and Molecular Imaging charged with the task to develop preclinical imaging curriculum for medical and bioengineering scientists and to address problems with standardization of small animal imaging protocols. Prof. Dobrucki is a co-founder of a biomedical startup company (PhantomCOR, Inc.) and a scientific consultant for Biobanking and Biomolecular Resources Research Infrastructure Poland.
Education
- B.S., bioengineering, Technical University of Hamburg, 1997
- M.Sc., bioengineering, Technical University of Wroclaw, 1997
- Ph.D., chemistry, Ohio University, 2003
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Honors
- 2021: Health Innovation Professor, Carle-Illinois College of Medicine, Urbana, IL
- 2020: Excellent Teachers List, University of Illinois at Urbana-Champaign, Urbana, IL
- 2019: Excellent Teachers List, University of Illinois at Urbana-Champaign, Urbana, IL
- 2015 – 2017: Senator, University of Illinois at Urbana-Champaign Senate
- 2012: Siemens Preclinical Image of the Year Award
- 2011: University of Illinois Research Board Award
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Research
Research areas:
Bioimaging at Multi-Scale
Biomedical imaging
Cancer
Diabetes-accelerated artherosclerosis
Molecular PET-CT
Multimodal probes for hybrid imaging of cardiovascular pathologies
Pathobiology/animal models for medicine
SPECT-CT
Vascular remodeling
The combination of different imaging modalities and technologies for mapping biomolecular and biological processes within single cell or whole organs has an extraordinary potential for revolutionizing the diagnosis and treatment of pathophysiological disorders, and thus for mitigating the significant social and economic costs associated with the clinical management of diseases.
The focus of Dr. Dobrucki’s research is to develop such integrated imaging approaches to noninvasively monitor and track physiologic processes including peripheral and myocardial angiogenesis and remodeling using functional and anatomical imaging modalities including SPECT/PET and X-ray CT, respectively. Such imaging strategies will eventually lead to individualized programs for disease prevention through advanced diagnosis, risk stratification and targeted cell therapies resulting in more successful and efficient health care.
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2021
- Insana, M. F., Zhu, Y., Babaei, S., Almora, D. M., Dobrucki, L. W., & Abbey, C. K. (2021). Clutter filtering strategies for peripheral muscle perfusion imaging using ultrasound. In B. C. Byram, & N. V. Ruiter (Eds.), Medical Imaging 2021: Ultrasonic Imaging and Tomography [116020M] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11602). SPIE. DOI: 10.1117/12.2580871
2020
- Dobrucki, LW & Sinusas, AJ 2020, 'Targeted Imaging of Abdominal Aortic Aneurysm: Biology Over Structure', Circulation. Cardiovascular imaging, vol. 13, no. 3, pp. e010495. DOI: 10.1161/CIRCIMAGING.120.010495
- Hedhli, J, Kim, MW, Knox, HJ, Cole, JA, Huynh, T, Schuelke, M, Dobrucki, IT, Kalinowski, L, Chan, J, Sinusas, AJ, Insana, MF & Dobrucki, LW 2020, 'Imaging the landmarks of vascular recovery', Theranostics, vol. 10, no. 4, pp. 1733-1745. DOI: 10.7150/thno.36022
- Konopka, CJ, Wozniak, M, Hedhli, J, Siekierzycka, A, Skokowski, J, Peksa, R, Matuszewski, M, Munirathinam, G, Kajdacsy-Balla, A, Dobrucki, IT, Kalinowski, L & Dobrucki, LW 2020, 'Quantitative imaging of the receptor for advanced glycation end-products in prostate cancer', European Journal of Nuclear Medicine and Molecular Imaging, vol. 47, no. 11, pp. 2562-2576. DOI: 10.1007/s00259-020-04721-1
2018
- Hedhli, J, Slania, SLL, Ploska, A, Czerwinski, A, Konopka, CJ, Wozniak, M, Banach, M, Dobrucki, IT, Kalinowski, L & Dobrucki, LW 2018, 'Evaluation of a dimeric-cRGD peptide for targeted PET-CT imaging of peripheral angiogenesis in diabetic mice', Scientific Reports, vol. 8, no. 1, 5401. DOI: 10.1038/s41598-018-23372-9
- Konopka, CJ, Wozniak, M, Hedhli, J, Ploska, A, Schwartz-Duval, A, Siekierzycka, A, Pan, D, Munirathinam, G, Dobrucki, IT, Kalinowski, L & Dobrucki, W 2018, 'Multimodal imaging of the receptor for advanced glycation end-products with molecularly targeted nanoparticles', Theranostics, vol. 8, no. 18, pp. 5012-5024. DOI: 10.7150/thno.24791
2017
- Hedhli, J, Czerwinski, A, Schuelke, M, Ploska, A, Sowinski, P, Hood, LL, Mamer, SB, Cole, JA, Czaplewska, P, Banach, M, Dobrucki, IT, Kalinowski, L, Imoukhuede, P & Dobrucki, LW 2017, 'Synthesis, Chemical Characterization and Multiscale Biological Evaluation of a Dimeric-cRGD Peptide for Targeted Imaging of a V ß 3 Integrin Activity', Scientific Reports, vol. 7, no. 1, 3185. DOI: 10.1038/s41598-017-03224-8
- Hedhli, J, Konopka, CJ, Schuh, S, Bouvin, H, Cole, JA, Huntsman, HD, Kilian, KA, Dobrucki, IT, Boppart, MD & Dobrucki, LW 2017, 'Multimodal assessment of mesenchymal stem cell therapy for diabetic vascular complications', Theranostics, vol. 7, no. 16, pp. 3876-3888. DOI: 10.7150/thno.19547
2016
- Mu, Z., Dobrucki, L. W., & Liu, Y. H. (2016). SPECT imaging of 2-D and 3-D distributed sources with near-field coded aperture collimation: Computer simulation and real data validation. Journal of Medical and Biological Engineering, 36(1), 32-43. DOI: 10.1007/s40846-016-0111-6
2015
- Dobrucki, L. W.; Pan, D.; Smith, A. M., Multiscale Imaging of Nanoparticle Drug Delivery. Current Drug Targets 2015, 16, (6), 560-570.
- Hedhli, J.; Schuh, S.; Czerwinski, A.; Huntsman, H.; Dobrucka, I.; Slania, S.; Boppart, M.; Dobrucki, L., Molecular Imaging of Stem Cells Induced Angiogenesis at the Onset of Microvascular Complications in Type-1 Diabetes. Journal of Nuclear Medicine 2015, 56, (3).
- Kalinowski, L.; Ploska, A.; Siekierzycka, A.; Dobrucki, L.; Wojciechowski, J.; Wozniak, M.; Rogowski, J.; Dobrucki, I., Association between Nadph Oxidase Activity and No Bioavailability in Human Blood Arteries of Hyperhomocysteinemic Patients. FASEB Journal 2015, 29.
- Li, J., Dobrucki, L. W., Marjanovic, M., Chaney, E. J., Suslick, K. S., & Boppart, S. A. (2015). Enhancement and wavelength-shifted emission of Cerenkov luminescence using multifunctional microspheres. Physics in medicine and biology, 60(2), 727-739. DOI: 10.1088/0031-9155/60/2/727
- Li, J.; Dobrucki, L. W.; Marjanovic, M.; Chaney, E. J.; Suslick, K. S.; Boppart, S. A., Enhancement and Wavelength-Shifted Emission of Cerenkov Luminescence using Multifunctional Microspheres. Physics in Medicine and Biology 2015, 60, (2), 727-739, DOI:10.1088/0031-9155/60/2/727.
- Tang, L.; Yin, Q.; Xu, Y. X.; Zhou, Q.; Cai, K. M.; Yen, J.; Dobruckic, L. W.; Cheng, J. J., Bioorthogonal Oxime Ligation Mediated in vivo Cancer Targeting. Chemical Science 2015, 6, (4), 2182-2186, DOI:10.1039/c5sc00063g.
2013
- Li, S., Sinusas, A. J., Dobrucki, L. W., & Liu, Y. H. (2013). New approach to quantification of molecularly targeted radiotracer uptake from hybrid cardiac SPECT/CT: Methodology and validation. Journal of Nuclear Medicine, 54(12), 2175-2181. DOI: 10.2967/jnumed.113.123208
- Xing, H., Tang, L., Yang, X., Hwang, K., Wang, W., Yin, Q., Wong, N. Y., Dobrucki, L. W., Yasui, N., Katzenellenbogen, J. A., Helferich, W. G., Cheng, J., & Lu, Y. (2013). Selective delivery of an anticancer drug with aptamer-functionalized liposomes to breast cancer cells in vitro and in vivo. Journal of Materials Chemistry B, 1(39), 5288-5297. DOI: 10.1039/c3tb20412j
- Yin, Q., Tong, R., Xu, Y., Baek, K., Dobrucki, L. W., Fan, T. M., & Cheng, J. (2013). Drug-initiated ring-opening polymerization of O-carboxyanhydrides for the preparation of anticancer drug-poly(O-carboxyanhydride) nanoconjugates. Biomacromolecules, 14(3), 920-929. DOI: 10.1021/bm301999c
- Yin, Q., Yap, F. Y., Yin, L., Ma, L., Zhou, Q., Dobrucki, L. W., Fan, T. M., Gaba, R. C., & Cheng, J. (2013). Poly(iohexol) nanoparticles as contrast agents for in vivo X-ray computed tomography imaging. Journal of the American Chemical Society, 135(37), 13620-13623. DOI: 10.1021/ja405196f
2012
- Domagala, T. B., Szeffler, A., Dobrucki, L. W., Dropinski, J., Polanski, S., Leszczynska-Wiloch, M., Kotula-Horowitz, K., Wojciechowski, J., Wojnowski, L., Szczeklik, A., & Kalinowski, L. (2012). Nitric oxide production and endothelium-dependent vasorelaxation ameliorated by N 1-methylnicotinamide in human blood vessels. Hypertension, 59(4), 825-832. DOI: 10.1161/HYPERTENSIONAHA.111.183210
- Hedhli, N., Dobrucki, L. W., Kalinowski, A., Zhuang, Z. W., Wu, X., Russell, R. R., Sinusas, A. J., & Russell, K. S. (2012). Endothelial-derived neuregulin is an important mediator of ischaemia-induced angiogenesis and arteriogenesis. Cardiovascular research, 93(3), 516-524. DOI: 10.1093/cvr/cvr352
- Tang, L., Yang, X., Dobrucki, L. W., Chaudhury, I., Yin, Q., Yao, C., Lezmi, S., Helferich, W. G., Fan, T. M., & Cheng, J. (2012). Aptamer-functionalized, ultra-small, monodisperse silica nanoconjugates for targeted dual-modal imaging of lymph nodes with metastatic tumors. Angewandte Chemie - International Edition, 51(51), 12721-12726. DOI: 10.1002/anie.201205271
2011
- Criscione, J. M., Dobrucki, L. W., Zhuang, Z. W., Papademetris, X., Simons, M., Sinusas, A. J., & Fahmy, T. M. (2011). Development and application of a multimodal contrast agent for SPECT/CT hybrid imaging. Bioconjugate Chemistry, 22(9), 1784-1792. DOI: 10.1021/bc200162r
- Razavian, M., Tavakoli, S., Zhang, J., Nie, L., Dobrucki, L. W., Sinusas, A. J., Azure, M., Robinson, S., & Sadeghi, M. M. (2011). Atherosclerosis plaque heterogeneity and response to therapy detected by in vivo molecular imaging of matrix metalloproteinase activation. Journal of Nuclear Medicine, 52(11), 1795-1802. DOI: 10.2967/jnumed.111.092379
- Sahul, Z. H., Mukherjee, R., Song, J., McAteer, J., Stroud, R. E., Dione, D. P., Staib, L., Papademetris, X., Dobrucki, L. W., Duncan, J. S., Spinale, F. G., & Sinusas, A. J. (2011). Targeted imaging of the spatial and temporal variation of matrix metalloproteinase activity in a porcine model of postinfarct remodeling relationship to myocardial dysfunction. Circulation: Cardiovascular Imaging, 4(4), 381-391. DOI: 10.1161/CIRCIMAGING.110.961854
2010
- Dobrucki, L. W., & Sinusas, A. J. (2010). PET and SPECT in cardiovascular molecular imaging. Nature Reviews Cardiology, 7(1), 38-47. DOI: 10.1038/nrcardio.2009.201
- Dobrucki, L. W., De Muinck, E. D., Lindner, J. R., & Sinusas, A. J. (2010). Approaches to multimodality imaging of angiogenesis. Journal of Nuclear Medicine, 51(SUPPL.1), 66S-79S. DOI: 10.2967/jnumed.110.074963
- Dobrucki, L. W., Tsutsumi, Y., Kalinowski, L., Dean, J., Gavin, M., Sen, S., Mendizabal, M., Sinusas, A. J., & Aikawa, R. (2010). Analysis of angiogenesis induced by local IGF-1 expression after myocardial infarction using microSPECT-CT imaging. Journal of Molecular and Cellular Cardiology, 48(6), 1071-1079. DOI: 10.1016/j.yjmcc.2009.10.008
2009
- Dobrucki, L. W., Dione, D. P., Kalinowski, L., Dione, D., Mendizabal, M., Yu, J., Papademetris, X., Sessa, W. C., & Sinusas, A. J. (2009). Serial noninvasive targeted imaging of peripheral angiogenesis: Validation and application of a semiautomated quantitative approach. Journal of Nuclear Medicine, 50(8), 1356-1363. DOI: 10.2967/jnumed.108.060822
- Dobrucki, L. W., Marsh, B. J., & Kalinowski, L. (2009). Elucidating structure-function relationships from molecule-to-cell-to-tissue: from research modalities to clinical realities. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 60 Suppl 4, 83-93.
- Dobrucki, L. W., Meoli, D. F., Hu, J., Sadeghi, M. M., & Sinusas, A. J. (2009). Regional hypoxia correlates with the uptake of a radiolabeled targeted marker of angiogenesis in rat model of myocardial hypertrophy and ischemic injury. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 60 Suppl 4, 117-123.
2008
- Kalinowski, L., Dobrucki, L. W., Meoli, D. F., Dione, D. P., Sadeghi, M. M., Madri, J. A., & Sinusas, A. J. (2008). Targeted imaging of hypoxia-induced integrin activation in myocardium early after infarction. Journal of Applied Physiology, 104(5), 1504-1512. DOI: 10.1152/japplphysiol.00861.2007
- Zhang, J., Nie, L., Razavian, M., Ahmed, M., Dobrucki, L. W., Asadi, A., Edwards, D. S., Azure, M., Sinusas, A. J., & Sadeghi, M. (2008). Molecular imaging of activated matrix metalloproteinases in vascular remodeling. Circulation, 118(19), 1953-1960. DOI: 10.1161/CIRCULATIONAHA.108.789743
2007
- Dobrucki, L. W., & Sinusas, A. J. (2007). Imaging angiogenesis. Current Opinion in Biotechnology, 18(1), 90-96. DOI: 10.1016/j.copbio.2007.01.005
2006
- Lindsey, M. L., Escobar, G. P., Dobrucki, L. W., Goshorn, D. K., Bouges, S., Mingoia, J. T., McClister, D. M., Su, H., Gannon, J., MacGillivray, C., Lee, R. T., Sinusas, A. J., & Spinale, F. G. (2006). Matrix metalloproteinase-9 gene deletion facilitates angiogenesis after myocardial infarction. American Journal of Physiology - Heart and Circulatory Physiology, 290(1), H232-H239. DOI: 10.1152/ajpheart.00457.2005
2005
- Dobrucki, L. W., & Sinusas, A. J. (2005). Cardiovascular molecular imaging. Seminars in Nuclear Medicine, 35(1), 73-81. DOI: 10.1053/j.semnuclmed.2004.09.006
- Dobrucki, L. W., & Sinusas, A. J. (2005). Molecular cardiovascular imaging. Current Cardiology Reports, 7(2), 130-135. DOI: 10.1007/s11886-005-0025-3
- Hua, J., Dobrucki, L. W., Sadeghi, M. M., Zhang, J., Bourke, B. N., Cavaliere, P., Song, J., Chow, C., Jahanshad, N., Van Royen, N., Buschmann, I., Madri, J. A., Mendizabal, M., & Sinusas, A. J. (2005). Noninvasive imaging of angiogenesis with a 99mTc-labeled peptide targeted at avß3 integrin after murine hindlimb ischemia. Circulation, 111(24), 3255-3260. DOI: 10.1161/CIRCULATIONAHA.104.485029
- Su, H., Spinale, F. G., Dobrucki, L. W., Song, J., Hua, J., Sweterlitsch, S., Dione, D. P., Cavaliere, P., Chow, C., Bourke, B. N., Hu, X. Y., Azure, M., Yalamanchili, P., Liu, R., Cheesman, E. H., Robinson, S., Edwards, D. S., & Sinusas, A. J. (2005). Noninvasive targeted imaging of matrix metalloproteinase activation in a murine model of postinfarction remodeling. Circulation, 112(20), 3157-3167. DOI: 10.1161/CIRCULATIONAHA.105.583021
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2021
2020
2019
- Researchers awarded $2.4M to develop imaging to detect microvascular changes in diabetic patients
- 2019 Carle Hospital-Beckman Institute Fellow announced
- Seven named 2019 Beckman Institute Graduate Fellows
- 9 projects with Beckman researchers receive funding from the Cancer Center
- Dobrucki named co-chair of Integrative Imaging research theme
2018
- Beckman researchers receive NIH RO1
- Researchers develop imaging agent for receptor that is key to multiple diseases
- Nowhere to hide: Molecular probe illuminates elusive cancer stem cells in live mice
- Three startups with Beckman connections chosen for iVenture accelerator
- Dobrucki to discuss multimodal imaging approaches at April 5 Beckman Director’s seminar
2017
- The beat goes on: group works on developing heart phantom
- Stem cells from muscle could address diabetes-related circulation problems
- Dobrucki collaborates with Kilian on study discovering stemlike cells at tumor perimeter
- Program provides undergrads with research experience, professional development
- Student teams fare well in local entrepreneurial competition
- Beckman researchers among inaugural faculty for Carle Illinois College of Medicine
- Through PhantomCor, doctors will be able to create 3D model of your heart
- Tumor-targeting system uses cancer’s own mechanisms to betray its location
2014