Wawrzyniec (Wawosz) Lawrence Dobrucki is currently Associate Professor and Director of Professional Master's Program in the Department of Bioengineering with affiliations in the Carle Illinois College of Medicine and the Carle R. Woese Institute for Genomic Biology at the University of Illinois at Urbana-Champaign, as well as the Medical University of Gdansk in Poland. He holds a full-time faculty position at the Beckman Institute for Advanced Science, where he serves as co-chair for the Integrative Imaging theme and directs the Experimental Molecular Imaging Laboratory (EMIL).
His expertise is in preclinical molecular imaging, and his fields of professional interests include the development of novel targeted multimodal imaging strategies to noninvasively assess tissue microenvironments and various biological processes in vivo, including therapeutic neovascularization, atherosclerosis, neoplastic progression and cancer response to experimental therapies.
Prof. Dobrucki is also involved in translational bioimaging utilizing his 15-plus years’ experience in the development and validation of novel SPECT/PET radiotracers and multimodal multifunctional contrast agents. He is an active member of the Preclinical Imaging Task Force at the Society of Nuclear Medicine and Molecular Imaging charged with the task to develop preclinical imaging curriculum for medical and bioengineering scientists and to address problems with standardization of small animal imaging protocols. Prof. Dobrucki is a co-founder of a biomedical startup company (PhantomCOR, Inc.) and a scientific consultant for Biobanking and Biomolecular Resources Research Infrastructure Poland.
Prof. Dobrucki received his Ph.D. in chemistry from Ohio University, Athens, in 2003, and M.Sc. degree in bioengineering from Technical University of Wroclaw, Poland and Technical University of Hamburg, Germany. Before joining the Department of Bioengineering as tenure-track faculty in Fall 2013, Prof. Dobrucki was a junior faculty member at Yale University School of Medicine and Senior Research Scientist at Beckman Institute where he directed the Molecular Imaging Laboratory (MIL) in the Biomedical Imaging Center (BIC).
The combination of different imaging modalities and technologies for mapping biomolecular and biological processes within single cell or whole organs has an extraordinary potential for revolutionizing the diagnosis and treatment of pathophysiological disorders, and thus for mitigating the significant social and economic costs associated with the clinical management of diseases.
The focus of Dr. Dobrucki’s research is to develop such integrated imaging approaches to noninvasively monitor and track physiologic processes including peripheral and myocardial angiogenesis and remodeling using functional and anatomical imaging modalities including SPECT/PET and X-ray CT, respectively. Such imaging strategies will eventually lead to individualized programs for disease prevention through advanced diagnosis, risk stratification and targeted cell therapies resulting in more successful and efficient health care.
- Dobrucki, L. W.; Pan, D.; Smith, A. M., Multiscale Imaging of Nanoparticle Drug Delivery. Current Drug Targets 2015, 16, (6), 560-570.
- Hedhli, J.; Schuh, S.; Czerwinski, A.; Huntsman, H.; Dobrucka, I.; Slania, S.; Boppart, M.; Dobrucki, L., Molecular Imaging of Stem Cells Induced Angiogenesis at the Onset of Microvascular Complications in Type-1 Diabetes. Journal of Nuclear Medicine 2015, 56, (3).
- Kalinowski, L.; Ploska, A.; Siekierzycka, A.; Dobrucki, L.; Wojciechowski, J.; Wozniak, M.; Rogowski, J.; Dobrucki, I., Association between Nadph Oxidase Activity and No Bioavailability in Human Blood Arteries of Hyperhomocysteinemic Patients. FASEB Journal 2015, 29.
- Li, J.; Dobrucki, L. W.; Marjanovic, M.; Chaney, E. J.; Suslick, K. S.; Boppart, S. A., Enhancement and Wavelength-Shifted Emission of Cerenkov Luminescence using Multifunctional Microspheres. Physics in Medicine and Biology 2015, 60, (2), 727-739, DOI:10.1088/0031-9155/60/2/727.
- Li, J.; Dobrucki, L. W.; Marjanovic, M.; Chaney, E. J.; Suslick, K. S.; Boppart, S. A., Enhancement and Wavelength-Shifted Emission of Cerenkov Luminescence Using Multifunctional Microspheres. Physics in Medicine and Biology 2015, 60, (2), 727-739, DOI:10.1088/0031-9155/60/2/727.
- Tang, L.; Yin, Q.; Xu, Y. X.; Zhou, Q.; Cai, K. M.; Yen, J.; Dobruckic, L. W.; Cheng, J. J., Bioorthogonal Oxime Ligation Mediated in vivo Cancer Targeting. Chemical Science 2015, 6, (4), 2182-2186, DOI:10.1039/c5sc00063g.
- Li S, Sinusas AJ, Dobrucki LW, Liu YH “New Approach to Quantification of Molecularly Targeted Radiotracer Uptake from Hybrid Cardiac SPECT/CT: Methodology and Validation” J Nucl Med. 2013 Dec;54(12):2175-81
- Xing H, Tang L, Yang X, Hwang K, Wang W, Yin Q, Wong NY, Dobrucki LW, Yasui N, Katzenellenbogen JA, Helferich WG, Cheng J, Lu Y. “Selective Delivery of an Anticancer Drug with Aptamer-Functionalized Liposomes to Breast Cancer Cells in Vitro and in Vivo” J Mater Chem B Mater Biol Med. 2013 Oct 21;1(39):5288-5297
- Yin Q, Tong R, Xu Y, Dobrucki LW, Fan TM, Cheng, J. "Drug-Initiated Ring-Opening Polymerization of OCarboxyanhydrides for the Preparation of Anticancer Drug-Poly-(O-Carboxyanhydride) Nanoconjugates" Biomacromolecules 2013; 14(3): 920-929
- Yin Q, Yap FY, Yin L, Ma L, Zhou Q, Dobrucki LW, Fan TM, Gaba RC, Cheng J. “Poly(iohexol) Nanoparticles As Contrast Agents for in Vivo X-ray Computed Tomography Imaging” J Am Chem Soc. 2013;135(37):13620-3
- Domagala TB, Szeffler A, Dobrucki LW, Dropinski J, Polanski S, Leszczynska-Wiloch M, Kotula-Horowitz K, Wojciechowski J, Wojnowski L, Szczeklik A, Kalinowski L. “Nitric oxide production and endothelium-dependent vasorelaxation ameliorated by N1-methylnicotinamide in human blood vessels” Hypertension 2012 ;59(4):825-32
- Hedhli N, Dobrucki LW, Kalinowski A, Zhuang ZW, Wu X, Russell RR 3rd, Sinusas AJ, Russell KS. “Endothelial Derived Neuregulin is an Important Mediator of Ischemic Induced Angiogenesis and Arteriogenesis” Cardiovasc Res. 2012; 93(3): 516-24.
- Tang L, Yang X, Dobrucki LW, Chaudhury I, Yin Q, Yao C, Lezmi S, Helferich WG, Fan TM, Cheng J. “Aptamerfunctionalized, ultra-small, monodisperse silica nanoconjugates for targeted dual-modal imaging of lymph nodes with metastatic tumors”. Angew Chem Int Ed Engl. 2012 Dec 14;51(51):12721-6
- Criscione JM, Dobrucki LW, Zhuang ZW, Papademetris X, Simons M, Sinusas AJ, Fahmy TM. “Development and application of a multimodal contrast agent for SPECT/CT hybrid imaging” Bioconjug Chem. 2011 Sep 21;22(9):1784-92
- Razavian M, Tavakoli S, Zhang J, Nie L, Dobrucki LW, Sinusas AJ, Azure M, Robinson S, Sadeghi MM. “Atherosclerosis plaque heterogeneity and response to therapy detected by in vivo molecular imaging of matrix metalloproteinase activation” J Nucl Med. 2011 Nov;52(11):1795-802.
- Sahul ZH, Mukherjee R, Song J, McAteer J, Stroud RE, Dione DP, Staib L, Papademetris X, Dobrucki LW, Duncan JS, Spinale FG, Sinusas AJ. “Targeted imaging of the spatial and temporal variation of matrix metalloproteinase activity in a porcine model of postinfarct remodeling: relationship to myocardial dysfunction” Circ Cardiovasc Imaging. 2011 Jul;4(4):381-91
- Dobrucki LW, de Muinck ED, Lindner JR, Sinusas AJ “Approaches to multimodality imaging of angiogenesis” J Nucl Med. 2010 May 1;51 Suppl 1:66S-79S. Review.
- Dobrucki LW, Sinusas AJ “PET and SPECT in cardiovascular molecular imaging” Nat Rev Cardiol. 2010 Jan;7(1):38-47.
- Dobrucki LW, Tsutsumi Y, Kalinowski L, Dean J, Gavin M, Sen S, Mendizabal M, Sinusas AJ, Aikawa R. “Analysis of angiogenesis induced by local IGF-1 expression after myocardial infarction using microSPECT-CT imaging.” J Mol Cell Cardiol. 2010 Jun;48(6):1071-9
- Dobrucki LW, Dione D, Kalinowski L, Dione D, Mendizabal M, Yu J, Papademetris X, Sessa WC, Sinusas AJ. “Serial non-invasive targeted imaging of peripheral angiogenesis: Validation and application of a semi-automated quantitative approach” J. Nucl Med 2009; 50:1356-1363
- Dobrucki LW, Marsh BJ, Kalinowski L. “Elucidating structure-function relationships from molecule-to-cell-to-tissue: from research modalities to clinical realities.” J Physiol Pharmacol. 2009 Oct;60 Suppl 4:83-93
- Dobrucki LW, Meoli DF, Hu J, Sadeghi MM, Sinusas AJ. “Regional hypoxia correlates with the uptake of a radiolabeled targeted marker of angiogenesis in rat model of myocardial hypertrophy and ischemic injury.” J Physiol Pharmacol. 2009 Oct;60 Suppl 4:117-23.
- Kalinowski L, Dobrucki LW, Meoli DF, Dione DP, Sadeghi MM, Madri JA, Sinusas AJ. “Targeted imaging of hypoxia-induced integrin activation in myocardium early after infarction” J Appl Physiol. 2008 May;104(5):1504-12
- Zhang J, Nie L, Razavian M, Ahmed M, Dobrucki LW, Asadi A, Edwards DS, Azure M, Sinusas AJ, Sadeghi MM. “Molecular imaging of activated matrix metalloproteinases in vascular remodeling” Circulation 2008 ;118(19):1953-60
- Dobrucki LW, and Sinusas AJ “Imaging angiogenesis” Curr Opin Biotechnol. 2007 Feb;18(1):90-6
- Lindsey ML, Escobar GP, Dobrucki LW, Goshorn DK, Bouges S, Mingoia JT, McClister Jr DM, Su H, Gannon J, Macgillivray C, Lee RT, Sinusas AJ, Spinale FG “Matrix Metalloproteinase-9 Gene Deletion Facilitates Angiogenesis Following Myocardial Infarction” Am J Physiol Heart Circ Physiol. 2006; 290(1):H232-H239
- Dobrucki LW, and Sinusas AJ “Cardiovascular Molecular Imaging” Sem Nucl Med 2005; 35(1):73-81
- Dobrucki LW, and Sinusas AJ “Molecular Cardiovascular Imaging” Curr Cardiol Rep 2005; 7(2):130-5.
- Hua J, Dobrucki LW, Sadeghi MM, Zhang J, Bourke BN, Cavaliere P, Song J, Chow C, Jahanshad N, van Royen N, Madri JA, Mendizabal M, Buschmann I, and Sinusas AJ “Noninvasive Imaging of Angiogenesis With a 99mTc-Labeled Peptide Targeted at avb3 Integrin Following Murine Hindlimb Ischemia” Circulation 2005; 111(24): 3255-60
- Su H, Spinale FG, Dobrucki LW, Song J, Hua J, Sweterlitsch S, Dione DP, Cavaliere P, Chow C, Bourke BN, Hu XY, Azure M, Yalamanchili P, Liu R, Cheesman EH, Robinson S, Edwards DS, Sinusas AJ “Noninvasive targeted imaging of matrix metalloproteinase activation in a murine model of postinfarction remodeling” Circulation. 2005;112(20):3157-67
- Researchers awarded $2.4M to develop imaging to detect microvascular changes in diabetic patients
- 2019 Carle Hospital-Beckman Institute Fellow announced
- Seven named 2019 Beckman Institute Graduate Fellows
- 9 projects with Beckman researchers receive funding from the Cancer Center
- Dobrucki named co-chair of Integrative Imaging research theme
- Beckman researchers receive NIH RO1
- Researchers develop imaging agent for receptor that is key to multiple diseases
- Nowhere to hide: Molecular probe illuminates elusive cancer stem cells in live mice
- Three startups with Beckman connections chosen for iVenture accelerator
- Dobrucki to discuss multimodal imaging approaches at April 5 Beckman Director’s seminar
- The beat goes on: group works on developing heart phantom
- Stem cells from muscle could address diabetes-related circulation problems
- Dobrucki collaborates with Kilian on study discovering stemlike cells at tumor perimeter
- Program provides undergrads with research experience, professional development
- Student teams fare well in local entrepreneurial competition
- Beckman researchers among inaugural faculty for Carle Illinois College of Medicine
- Through PhantomCor, doctors will be able to create 3D model of your heart
- Tumor-targeting system uses cancer’s own mechanisms to betray its location