Primary AffiliationMolecular Design and Engineering
Alexey Bezryadin recieved his PH.D. from the Joseph Fourier University and Low-Temperature Research Center (CRTBT-CNRS), Grenoble, France in 1995. He is currently an assistant Professor in the Illinois Department of Physics and an affiliate faculty member in the Beckman Institute Nanoelectronics and Nanomaterials group. He is also a Research Assistant Professor at the Illinois Micro and Nanotechnology Laboratory.
Fellow, American Physical Society (2014); Center for Advanced Study Fellow (2004); Xerox Junior Faculty Research Award (2004); National Science Foundation CAREER Award (2002); Alfred P. Sloan Foundation Fellowship (2002); Citation for outstanding Ph.D. thesis work ("Avec Mention et Félicitations du Jury") Joseph Fourier University, Grenoble, France (1995).
The main goal of the reseach is to apply biological machines as tools to achieve high-resolution, high-rate imaging on the molecular level. Several proof-of-principle studies have been reported that interfaced molecular motors with nanoscale man-made objects, but the dream of using Nature's own nanomachines for practical applications has yet to be realized. Thus, molecular motors remain interesting structures that stir the imagination but which have not been used to create practically important functional devices.
We aim to make this important step by combining nanofabrication, kinesin-mediated microtubule transport, microfluidics, and optical single-molecule detection. It is expected that a resolution of ~50 nm or less can be achieved, on single molecules or segments of DNA molecules, using near-field optical slit microscopy. A molecular motor, based on a microtubule-kinesin interaction, will perform this task. If successful, this approach will enable rapid DNA mapping and possibly single-nucleotide polymorphism identification with ~10 times higher spatial resolution at the single-DNA-molecule level in a massively parallel way. Also, if successful, this method will probably be the first practical application of molecular motors, which have attracted much attention recently but so far have not provided many practical solutions to important technological problems.
- Murphy, D. V. Averin, and A. Bezryadin. Nanoscale superconducting memory based on the kinetic inductance of asymmetric nanowire loops. New J. Phys. 19, 063015 (2017).
- Arutyunov, K. Y., Ramos-Álvarez, A., Semenov, A. V., Korneeva, Y. P., An, P. P., Korneev, A. A., Murphy, A., Bezryadin, A. & Gol'Tsman, G. N. Superconductivity in highly disordered NbN nanowires. Nanotechnology 2016, 27, 47, 47LT02.
- Bezryadin, A. & Kountz, E. Training concept, evolution time, and the maximum entropy production principle. Entropy 2016, 18, 4, 145.
- Ku, J., Yoscovits, Z., Levchenko, A., Eckstein, J. & Bezryadin, A. Decoherence and radiation-free relaxation in Meissner transmon qubit coupled to Abrikosov vortices. Physical Review B - Condensed Matter and Materials Physics 2016, 94, 16, 165128.
- Belkin, A., Belkin, M., Vakaryuk, V., Khlebnikov, S. & Bezryadin, A. Formation of quantum phase slip pairs in superconducting nanowires. Physical Review X 2015, 5, 2, 021023.
- Belkin, A., Hubler, A. & Bezryadin, A. Self-assembled wiggling nano-structures and the principle of maximum entropy production. Scientific Reports 2015, 5, 8323.
- Gordon, E. B., Bezryadin, A. V., Karabulin, A. V., Matyushenko, V. I. & Khodos, I. I. Suppression of superconductivity in thin Nb nanowires fabricated in the vortex cores of superfluid helium. Physica C: Superconductivity and its Applications 2015, 516, 44-49, 1252879.
- Hubler, A., Belkin, A. & Bezryadin, A. Noise induced phase transition between maximum entropy production structures and minimum entropy production structures? Complexity 2015, 20, 3, 8-11.
- Murphy, A., Semenov, A., Korneev, A., Korneeva, Y., Gol'tsman, G. & Bezryadin, A. Three temperature regimes in superconducting photon detectors: Quantum, thermal and multiple phase-slips as generators of dark counts. Scientific Reports 2015, 5, 10174.
- Bezryadin. Superconductivity in Nanowires (Wiley-VCH, Weinheim, Germany, 2013).
- Draskovic, J., Lemberger, T. R., Peters, B., Yang, F., Ku, J., Bezryadin, A. & Wang, S. Measuring the superconducting coherence length in thin films using a two-coil experiment. Physical Review B - Condensed Matter and Materials Physics 2013, 88, 13, 134516.
- Murphy, A., Weinberg, P., Aref, T., Coskun, U. C., Vakaryuk, V., Levchenko, A. & Bezryadin, A. Universal features of counting statistics of thermal and quantum phase slips in nanosize superconducting circuits. Physical Review Letters 2013, 110, 24, 247001.
- Shinn, E., Hübler, A., Lyon, D., Perdekamp, M. G., Bezryadin, A. & Belkin, A. Nuclear energy conversion with stacks of graphene nanocapacitors. Complexity 2013, 18, 3, 24-27.
- Aref, T., Levchenko, A., Vakaryuk, V. & Bezryadin, A. Quantitative analysis of quantum phase slips in superconducting Mo 76Ge 24 nanowires revealed by switching-current statistics. Physical Review B - Condensed Matter and Materials Physics 2012, 86, 2, 024507.
- Bae, M. H., Dinsmore, R. C., Sahu, M. & Bezryadin, A. Stochastic and deterministic phase slippage in quasi-one-dimensional superconducting nanowires exposed to microwaves. New Journal of Physics 2012, 14, 043014.
- Brenner, M. W., Roy, D., Shah, N. & Bezryadin, A. Dynamics of superconducting nanowires shunted with an external resistor. Physical Review B - Condensed Matter and Materials Physics 2012, 85, 22, 224507.
- Coskun, U. C., Brenner, M., Hymel, T., Vakaryuk, V., Levchenko, A. & Bezryadin, A. Distribution of supercurrent switching in graphene under the proximity effect. Physical Review Letters 2012, 108, 9, 097003.
- Hopkins, D.; Pekker, D.; Goldbart, P.; Bezryadin, A. Superconducting phase gradiometer made using DNA molecular templates. Science 2005, 308, 1762.
- Re-meika, M. and Bezryadin, A. Electron-beam-induced crystallization and nanostructuring of suspended metallic nanowires. Nanotechnology 2005, 16, 1172-1176.
- Rogachev, A.; Bollinger, A.T.; Bezryadin, A. Influence of high magnetic fields on the superconducting transition of one-dimensional Nb and MoGe nanowires. Physical Review Letters 2005, 94, 017004.
- Coskun, U.C.; Wei, T.C.; Visveshwara, S.; Goldbart, P.; Bezryadin, A. h/e Magnetic Flux Modulation of the Energy Gap in Nanotube Quantum Dots. Science 2004, 304, 1132.
- Bezryadin, A., Lau, C.N., and Tinkham, M. (2000), "Quantum suppression of superconductivity in ultrathin nanowires," Nature, 404, pp. 971-974.
- Porath, D., Bezryadin, A., de Vries, S., and Dekker, C. (2000), "Direct measurements of electrical transport through DNA molecules," Nature, 403, pp. 635-638.