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Sayeepriyadarshini Anakk

Professor

Primary Affiliation

Extracellular Vesicle Imaging and Therapy

Affiliations

Status Affiliate Faculty

Home Department of Molecular and Integrative Physiology

Phone

Email anakk@illinois.edu

Address

  • Biography

    Sayeepriyadarshini Anakk is an associate professor in the Department of Molecular and Integrative Physiology.

    Education

    • B.S, pharmacy, Birla Institute of Technology & Sciences, Pilani, India
    • M.S., biological sciences, Birla Institute of Technology & Sciences, Pilani, India 
    • Ph.D., biochemistry, University of Texas, Graduate School of Biomedical Sciences at Houston 
  • Honors
    • 2020: Listed in "Teachers Ranked as Excellent"
    • 2016: Outstanding Advisor Award, Medical Scholars Program, UIUC, IL
    • 2016: Presidential Poster Judge, Annual Endocrine Society meeting, Boston, MA
    • 2016: Medical Scholars Program Outstanding Mentor Award
    • 2015: Invited Speaker, Nuclear Receptor signaling and cancer, Annual Endocrine Society meeting, San Diego, CA
    • 2015: Oral Session Chair, Nuclear Receptors and Kinases: Intertwined in Cancer, Obesity and Brain Disorders at the Annual Endocrine Society meeting, San Diego, CA
    • 2015: Travel Award, South East Lipid Research Conference, Atlanta, Georgia

     

  • Research

    Research Interests:

    • Endocrinology

    • Metabolic Regulation

    • Regulation of Gene Expression

    • Cancer

    • Metabolic Disorders/Diabetes

    Dr. Sayeepriyadarshini Anakk’s research focuses on understanding liver metabolism in normal and diseased states. Her goal is to investigate how bile acids and nuclear receptors maintain metabolic homeostasis and contribute to liver diseases, including cancer, using cell-based systems and genetically engineered mouse models.

  • 2024

    • Chenodeoxycholic Acid-Loaded Nanoparticles Are Sufficient to Decrease Adipocyte Size by Inducing Mitochondrial Function Zhou, W., Lew, B., Choi, H., Kim, K. and Anakk, S., Feb 7 2024, In: Nano letters. 24, 5, p. 1642-1649 8 p.
    • Diindoles produced from commensal microbiota metabolites function as endogenous CAR/Nr1i3 ligands Liu, J., Malekoltojari, A., Asokakumar, A., Chow, V., Li, L., Li, H., Grimaldi, M., Dang, N., Campbell, J., Barrett, H., Sun, J., Navarre, W., Wilson, D., Wang, H., Mani, S., Balaguer, P., Anakk, S., Peng, H. and Krause, H. M., Dec 2024, In: Nature communications. 15, 1, 2563.

    2023

    • Depletion of IQ motif-containing GTPase activating protein 2 (IQGAP2) reduces hepatic glycogen and impairs insulin signaling Sen, A., Youssef, S., Wendt, K. and Anakk, S., Nov 2023, In: Journal of Biological Chemistry. 299, 11, 105322.
    • Hepatic farnesoid X receptor is necessary to facilitate ductular reaction and expression of heme biosynthetic genes Dean, A. E., Jungwirth, E., Panzitt, K., Wagner, M. and Anakk, S., Oct 2023, In: Hepatology Communications. 7, 10, e0213.
    • Pathological bile acid concentrations in chronic cholestasis cause adipose mitochondrial defects Zhou, W., VanDuyne, P., Zhang, C., Liu, Y., Riessen, R., Barragan, M., Rowitz, B. M., Teran-Garcia, M., Boppart, S. A. and Anakk, S., May 2023, In: JHEP Reports. 5, 5, 100714.
    • Splicing factor SRSF1 deficiency in the liver triggers NASH-like pathology and cell death Arif, W., Mathur, B., Saikali, M. F., Chembazhi, U. V., Toohill, K., Song, Y. J., Hao, Q., Karimi, S., Blue, S. M., Yee, B. A., Van Nostrand, E. L., Bangru, S., Guzman, G., Yeo, G. W., Prasanth, K. V., Anakk, S., Cummins, C. L. and Kalsotra, A., Feb 9 2023, In: Nature communications. 14, 1, 551.

    2022

    • Bile Acids-A Peek into Their History and Signaling Nguyen, J. T., Shaw, R. P. H. and Anakk, S., Nov 1 2022, In: Endocrinology (United States). 163, 11, bqac155.
    • Deletion of Constitutive Androstane Receptor Led to Intestinal Alterations and Increased Imidacloprid in Murine Liver Sen, A., Goforth, M., Cooper, K. K. and Anakk, S., Dec 1 2022, In: Journal of the Endocrine Society. 6, 12, bvac145.
    • Enterohepatic and non-canonical roles of farnesoid X receptor in controlling lipid and glucose metabolism Zhou, W. and Anakk, S., Jun 1 2022, In: Molecular and Cellular Endocrinology. 549, 111616.
    • Loss of Hepatic Small Heterodimer Partner Elevates Ileal Bile Acids and Alters Cell Cycle-related Genes in Male Mice Shaw, R. P. H., Kolyvas, P., Dang, N., Hyon, A., Bailey, K. and Anakk, S., Jun 1 2022, In: Endocrinology (United States). 163, 6, bqac052.
    • Melancholé: The Dark Side of Bile Acids and Its Cellular Consequences Zhou, W. and Anakk, S., Jan 2022, In: CMGH. 13, 5, p. 1474-1476 3 p.
    • Rebuttal to: The Benevolent Bile: Bile Acids as Stimulants of Liver Regeneration Zhou, W. and Anakk, S., Jan 2022, In: CMGH. 13, 5, p. 1481-1482 2 p.

    2021

    • Deletion of Intestinal SHP Impairs Short-term Response to Cholic Acid Challenge in Male Mice Nguyen, J. T., Riessen, R., Zhang, T., Kieffer, C. and Anakk, S., Aug 2021, In: Endocrinology (United States). 162, 8, bqab063.
    • Jekyll and Hyde: nuclear receptors ignite and extinguish hepatic oxidative milieu Sen, A. and Anakk, S., Oct 2021, In: Trends in Endocrinology and Metabolism. 32, 10, p. 790-802 13 p.
    • Nuclear receptors FXR and SHP regulate protein N-glycan modifications in the liver Mathur, B., Shajahan, A., Arif, W., Chen, Q., Hand, N. J., Abramowitz, L. K., Schoonjans, K., Rader, D. J., Kalsotra, A., Hanover, J. A., Azadi, P. and Anakk, S., Apr 21 2021, In: Science Advances. 7, 17, eabf4865.
    • Scaffolding protein IQGAP1 is dispensable, but its overexpression promotes hepatocellular carcinoma via YAP1 signaling Delgado, E. R., Erickson, H. L., Tao, J., Monga, S. P., Duncan, A. W. and Anakkb, S., Apr 2021, In: Molecular and cellular biology. 41, 4, e00596.
    • Sex differences feed into nuclear receptor signaling along the digestive tract Dean, A. E., Reichardt, F. and Anakk, S., Nov 1 2021, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1867, 11, 166211.

    2020

    • Bile acid treatment and FXR agonism lower postprandial lipemia in mice Farr, S., Stankovic, B., Hoffman, S., Masoudpoor, H., Baker, C., Taher, J., Dean, A. E., Anakk, S. and Adeli, K., 2020, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 318, 4, p. H682-G693
    • Fxr-alpha Skips Alternatively in Liver Metabolism Anakk, S. and Dean, A. E., Nov 2020, In: Gastroenterology. 159, 5, p. 1655-1657 3 p.
    • Transcriptomic analysis across liver diseases reveals disease-modulating activation of constitutive androstane receptor in cholestasis Mathur, B., Arif, W., Patton, M. E., Faiyaz, R., Liu, J., Yeh, J., Harpavat, S., Schoonjans, K., Kalsotra, A., Wheatley, A. M. and Anakk, S., Oct 2020, In: JHEP Reports. 2, 5, 100140.

    2019

    • Constitutive Androstane Receptor Differentially Regulates Bile Acid Homeostasis in Mouse Models of Intrahepatic Cholestasis Kim, K. H., Choi, J. M., Li, F., Dong, B., Wooton-Kee, C. R., Arizpe, A., Anakk, S., Jung, S. Y., Hartig, S. M. and Moore, D. D., Jan 2019, In: Hepatology Communications. 3, 1, p. 147-159 13 p.
    • Single-Cell Analysis of the Liver Epithelium Reveals Dynamic Heterogeneity and an Essential Role for YAP in Homeostasis and Regeneration Pepe-Mooney, B. J., Dill, M. T., Alemany, A., Ordovas-Montanes, J., Matsushita, Y., Rao, A., Sen, A., Miyazaki, M., Anakk, S., Dawson, P. A., Ono, N., Shalek, A. K., van Oudenaarden, A. and Camargo, F. D., Jul 3 2019, In: Cell Stem Cell. 25, 1, p. 23-38.e8
    • Small Heterodimer Partner Regulates Dichotomous T Cell Expansion by Macrophages Shahoei, S. H., Kim, Y. C., Cler, S. J., Ma, L., Anakk, S., Kemper, J. K. and Nelson, E. R., 2019, In: Endocrinology. 160, 7, p. 1573-1589 17 p.

    2018

    • Alternative splicing rewires Hippo signaling pathway in hepatocytes to promote liver regeneration Bangru, S., Arif, W., Seimetz, J., Bhate, A., Chen, J., Rashan, E. H., Carstens, R. P., Anakk, S. and Kalsotra, A., Oct 2018, In: Nature Structural and Molecular Biology. 25, 10, p. 928-939 12 p.
    • Identification of IQ motif-containing GTPase-activating protein 1 as a regulator of long-term ketosis Erickson, H. L. and Anakk, S., Nov 2 2018, In: JCI Insight. 3, 21
    • Xenobiotic nuclear receptor signaling determines molecular pathogenesis of progressive familial intrahepatic cholestasis Kim, K. H., Choi, J. M., Li, F., Arizpe, A., Wooton-Kee, C. R., Anakk, S., Jung, S. Y., Finegold, M. J. and Moore, D. D., Jun 1 2018, In: Endocrinology. 159, 6, p. 2435-2446 12 p.

    2017

    • Bile acid excess induces cardiomyopathy and metabolic dysfunctions in the heart Desai, M. S., Mathur, B., Eblimit, Z., Vasquez, H., Taegtmeyer, H., Karpen, S. J., Penny, D. J., Moore, D. D. and Anakk, S., Jan 1 2017, In: Hepatology. 65, 1, p. 189-201 13 p.
    • Hepatic FXR/SHP axis modulates systemic glucose and fatty acid homeostasis in aged mice Kim, K. H., Choi, S., Zhou, Y., Kim, E. Y., Lee, J. M., Saha, P. K., Anakk, S. and Moore, D. D., Aug 2017, In: Hepatology. 66, 2, p. 498-509 12 p.
    • Small heterodimer partner deletion prevents hepatic steatosis and when combined with farnesoid X receptor loss protects against type 2 diabetes in mice Akinrotimi, O., Riessen, R., VanDuyne, P., Park, J. E., Lee, Y. K., Wong, L. J., Zavacki, A. M., Schoonjans, K. and Anakk, S., Dec 2017, In: Hepatology. 66, 6, p. 1854-1865 12 p.

    2015

    • ESRP2 controls an adult splicing programme in hepatocytes to support postnatal liver maturation Bhate, A., Parker, D. J., Bebee, T. W., Ahn, J., Arif, W., Rashan, E. H., Chorghade, S., Chau, A., Lee, J. H., Anakk, S., Carstens, R. P., Xiao, X. and Kalsotra, A., Nov 4 2015, In: Nature communications. 6, 8768.

    2014

    • Cysteine sulfinic acid decarboxylase regulation: A role for farnesoid X receptor and small heterodimer partner in murine hepatic taurine metabolism Kerr, T. A., Matsumoto, Y., Matsumoto, H., Xie, Y., Hirschberger, L. L., Stipanuk, M. H., Anakk, S., Moore, D. D., Watanabe, M., Kennedy, S. and Davidson, N. O., Oct 1 2014, In: Hepatology Research. 44, 10, p. E218-E228
    • Vitamin D receptor activation down-regulates the small heterodimer partner and increases CYP7A1 to lower cholesterol Chow, E. C. Y., Magomedova, L., Quach, H. P., Patel, R., Durk, M. R., Fan, J., Maeng, H. J., Irondi, K., Anakk, S., Moore, D. D., Cummins, C. L. and Pang, K. S., Apr 2014, In: Gastroenterology. 146, 4, p. 1048-1059.e7

    2013

    • Bile Acids Activate YAP to Promote Liver Carcinogenesis Anakk, S., Bhosale, M., Schmidt, V. A., Johnson, R. L., Finegold, M. J. and Moore, D. D., Nov 27 2013, In: Cell Reports. 5, 4, p. 1060-1069 10 p.
    • Farnesoid X receptor inhibits gankyrin in mouse livers and prevents development of liver cancer Jiang, Y., Iakova, P., Jin, J., Sullivan, E., Sharin, V., Hong, I. H., Anakk, S., Mayor, A., Darlington, G., Finegold, M., Moore, D. and Timchenko, N. A., Mar 2013, In: Hepatology. 57, 3, p. 1098-1106 9 p.

    2011

    • Bile acid receptor agonist GW4064 regulates PPAR? coactivator-1a expression through estrogen receptor-related receptor a Dwivedi, S. K. D., Singh, N., Kumari, R., Mishra, J. S., Tripathi, S., Banerjee, P., Shah, P., Kukshal, V., Tyagi, A. M., Gaikwad, A. N., Chaturvedi, R. K., Mishra, D. P., Trivedi, A. K., Sanyal, S., Chattopadhyay, N., Ramachandran, R., Siddiqi, M. I., Bandyopadhyay, A., Arora, A. and Lundåsen, T. and 3 others, , Jun 2011, In: Molecular Endocrinology. 25, 6, p. 922-932 11 p.
    • Combined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis Anakk, S., Watanabe, M., Ochsner, S. A., McKenna, N. J., Finegold, M. J. and Moore, D. D., Jan 4 2011, In: Journal of Clinical Investigation. 121, 1, p. 86-95 10 p.
    • Dissociation of diabetes and obesity in mice lacking orphan nuclear receptor small heterodimer partner Park, Y. J., Kim, S. C., Kim, J., Anakk, S., Lee, J. M., Tseng, H. T., Yechoor, V., Park, J., Choi, J. S., Jang, H. C., Lee, K. U., Novak, C. M., Moore, D. D. and Lee, Y. K., Dec 2011, In: Journal of Lipid Research. 52, 12, p. 2234-2244 11 p.

    2007

    • Brain trauma leads to enhanced lung inflammation and injury: Evidence for role of P4504Fs in resolution Kalsotra, A., Zhao, J., Anakk, S., Dash, P. K. and Strobel, H. W., May 16 2007, In: Journal of Cerebral Blood Flow and Metabolism. 27, 5, p. 963-974 12 p.
    • Catalytic characterization and cytokine mediated regulation of cytochrome P450 4Fs in rat hepatocytes Kalsotra, A., Anakk, S., Brommer, C. L., Kikuta, Y., Morgan, E. T. and Strobel, H. W., May 1 2007, In: Archives of Biochemistry and Biophysics. 461, 1, p. 104-112 9 p.
    • Gender dictates the nuclear receptor-mediated regulation of CYP3A44 Anakk, S., Huang, W., Staudinger, J. L., Tan, K., Cole, T. J., Moore, D. D. and Strobel, H. W., Jan 1 2007, In: Drug Metabolism and Disposition. 35, 1, p. 36-42 7 p.

    2005

    • Renal localization, expression, and developmental regulation of P450 4F cytochromes in three substrains of spontaneously hypertensive rats Kalsotra, A., Cui, X., Anakk, S., Hinojos, C. A., Doris, P. A. and Strobel, H. W., Dec 9 2005, In: Biochemical and Biophysical Research Communications. 338, 1, p. 423-431 9 p.

    2004

    • CAR/PXR provides directives for Cyp3a41 gene regulation differently from Cyp3a11 Anakk, S., Kalsotra, A., Kikuta, Y., Huang, W., Zhang, J., Staudinger, J. L., Moore, D. D. and Strobel, H. W., Apr 1 2004, In: Pharmacogenomics Journal. 4, 2, p. 91-101 11 p.

    2003

    • Genomic characterization and regulation of CYP3a13: role of xenobiotics and nuclear receptors. Anakk, S., Kalsotra, A., Shen, Q., Vu, M. T., Staudinger, J. L., Davies, P. J. A. and Strobel, H. W., Sep 2003, In: The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 17, 12, p. 1736-1738 3 p.
    • Insights into gender bias: Rat cytochrome P450 3A9 Anakk, S., Ku, C. Y., Vore, M. and Strobel, H. W., May 1 2003, In: Journal of Pharmacology and Experimental Therapeutics. 305, 2, p. 703-709 7 p.

    2002

    • Sexual dimorphism and tissue specificity in the expression of CYP4F forms in Sprague Dawley rats Kalsotra, A., Anakk, S., Boehme, C. L. and Strobel, H. W., Sep 2002, In: Drug Metabolism and Disposition. 30, 9, p. 1022-1028 7 p.

    2000

    • Immobilization stress-induced changes in brain acetylcholinesterase activity and cognitive function in mice Das, A., Kapoor, K., Sayeepriyadarshini, A. T., Dikshit, M., Palit, G. and Nath, C., 2000, In: Pharmacological Research. 42, 3, p. 213-217 5 p.