Rohit Bhargava

Description

Address

  • 4265 Beckman Institute
  • 405 North Mathews Avenue
  • Urbana, Illinois 61801

Biography

Rohit Bhargava received his Ph.D. from Case Western Reserve University in 2000 and undergraduate degree from Indian Institute of Technology, New Delhi in 1996. He is a professor in the UIUC Department of Bioengineering and a full-time faculty member in the Beckman Institute Bioimaging Science and Technology group. His fields of professional interest are infrared spectroscopic imaging, cancer pathology, probes for molecular imaging, polymer structure and numerical methods for image processing.

Honors

Best Manuscript, Young Vibrational Spectroscopists, Vibrational Spectroscopy (2004), Meggers Award, Society for Applied Spectroscopy (1999 and 2002), Kirkbright Bursary Award, Association of British Spectroscopists (2001), Sigma Pi Epsilon Honor Society, Society of Plastics Engineers (2000), Graduate Spectroscopist (2000) and Maron Award, Case Western Reserve University (1998), IIT Undergraduate Research Award (1994) and National Science Talent Search Scholar (1989-1996).

Research

The central theme of research in our group is the development of novel chemical imaging technology and structures that can be employed to detect, diagnose and understand tissue structure and cancer pathology. These biological sensors may be optical (spectroscopic imaging), material (probes) or computational and physical models. Another major theme is the development of novel instrumentation approaches to fast, high fidelity infrared spectroscopic imaging and development of novel algorithms for information extraction from large imaging data sets.

Publications

  • 2014
    • DeVetter, B. M.; Bhargava, R.; Murphy, C. J., Computational Study of the Surface-Enhanced Raman Scattering from Silica-Coated Silver Nanowires. Photochemistry and Photobiology 2014, 90, (2), 415-418, DOI: 10.1111/php.12205.

    • Holton, S. E.; Bergamaschi, A.; Katzenellenbogen, B. S.; Bhargava, R., Integration of Molecular Profiling and Chemical Imaging to Elucidate Fibroblast-Microenvironment Impact on Cancer Cell Phenotype and Endocrine Resistance in Breast Cancer. Plos One 2014, 9, (5), e96878.

    • Mayerich, D.; van Dijk, T.; Walsh, M.; Schulmerich, M.; Carney, P. S.; Bhargava, R., Quantitative Confocal Phase Imaging by Synthetic Optical Holography. Analyst 2014, 10, 1039.

  • 2013
    • Abouimrane, A.; Odom, S. A.; Tavassol, H.; Schulmerich, M. V.; Wu, H. M.; Bhargava, R.; Gewirth, A. A.; Moore, J. S.; Amine, K., 3-Hexylthiophene as a Stabilizing Additive for High Voltage Cathodes in Lithium-Ion Batteries. Journal of the Electrochemical Society 2013, 160, (2), A268-A271, DOI: 10.1149/2.039302jes.

    • Kodali, A. K.; Schulmerich, M.; Palekar, R.; Bhargava, R., Sculpting the Analytical Volume in and around Nanoparticle Sensors Using a Multilayer Geometry. Analytical Chemistry 2013, 85, (8), 3842-3848.

    • Kwon, B.; Jiang, J.; Schulmerich, M. V.; Xu, Z. D.; Bhargava, R.; Liu, G. L.; King, W. P., Bimaterial Microcantilevers with Black Silicon Nanocone Arrays. Sensors and Actuators A-Physical 2013, 199, 143-148, DOI: 10.1016/j.sna.2013.05.007.

    • Kwon, B.; Schulmerich, M. V.; Bhargava, R.; King, W. P., Infrared Emission from Heated Microcantilevers. Nanoscale and Microscale Thermophysical Engineering 2013, 17, (2), 141-153, DOI: 10.1080/15567265.2012.760693.

    • Kwon, B.; Seong, M.; Liu, J. N.; Rosenberger, M. R.; Schulmerich, M. V.; Bhargava, R.; Cunningham, B. T.; King, W. P., Large Infrared Absorptance of Bimaterial Microcantilevers Based on Silicon High Contrast Grating. Journal of Applied Physics 2013, 114, (15), DOI: 10.1063/1.4825313.

    • Liu, Y. Y.; Zhang, C. Y.; Hu, D. H.; Kuhlenschmidt, M. S.; Kuhlenschmidt, T. B.; Mylon, S. E.; Kong, R.; Bhargava, R.; Nguyen, T. H., Role of Collector Alternating Charged Patches on Transport of Cryptosporidium Parvum Oocysts in a Patchwise Charged Heterogeneous Micromodel. Environmental Science & Technology 2013, 47, (6), 2670-2678.

    • Mayerich, D.; Walsh, M.; Schulmerich, M.; Bhargava, R., Real-Time Interactive Data Mining for Chemical Imaging Information: Application to Automated Histopathology. BMC Bioinformatics 2013, 14, DOI: 10.1186/1471-2105-14-156.

    • Moreno-Torres, J. G.; Llora, X.; Goldberg, D. E.; Bhargava, R., Repairing Fractures between Data Using Genetic Programming-Based Feature Extraction: A Case Study in Cancer Diagnosis. Information Sciences 2013, 222, 805-823.

    • Reddy, R. K.; Walsh, M. J.; Schulmerich, M. V.; Carney, P. S.; Bhargava, R., High-Definition Infrared Spectroscopic Imaging. Applied Spectroscopy 2013, 67, (1), 86-92.

    • Shah, A. B.; Sivapalan, S. T.; DeVetter, B. M.; Yang, T. K.; Wen, J. G.; Bhargava, R.; Murphy, C. J.; Zuo, J. M., High-Index Facets in Gold Nanocrystals Elucidated by Coherent Electron Diffraction. Nano Letters 2013, 13, (4), 1840-1846.

    • Sivapalan, S. T.; DeVetter, B. M.; Yang, T. K.; Schulmerich, M. V.; Bhargava, R.; Murphy, C. J., Surface-Enhanced Raman Spectroscopy of Polyelectrolyte-Wrapped Gold Nanoparticles in Colloidal Suspension. Journal of Physical Chemistry C 2013, 117, (20), 10677-10682, DOI: 10.1021/jp402392y.

    • Sivapalan, S. T.; DeVetter, B. M.; Yang, T. K.; van Dijk, T.; Schulmerich, M. V.; Carney, P. S.; Bhargava, R.; Murphy, C. J., Off-Resonance Surface-Enhanced Raman Spectroscopy from Gold Nanorod Suspensions as a Function of Aspect Ratio: Not What We Thought. ACS Nano 2013, 7, (3), 2099-2105.

    • van Dijk, T.; Mayerich, D.; Bhargava, R.; Carney, P. S., Rapid Spectral-Domain Localization. Optics Express 2013, 21, (10), 12822-12830, DOI: 10.1364/oe.21.012822.

    • van Dijk, T.; Mayerich, D.; Carney, P. S.; Bhargava, R., Recovery of Absorption Spectra from Fourier Transform Infrared (FT-IR) Microspectroscopic Measurements of Intact Spheres. Applied Spectroscopy 2013, 67, (5), 546-552, DOI: 10.1366/12-06847.

    • van Dijk, T.; Sivapalan, S. T.; DeVetter, B. M.; Yang, T. K.; Schulmerich, M. V.; Murphy, C. J.; Bhargava, R.; Carney, P. S., Competition between Extinction and Enhancement in Surface-Enhanced Raman Spectroscopy. Journal of Physical Chemistry Letters 2013, 4, (7), 1193-1196.

    • Yeh, K.; Schulmerich, M.; Bhargava, R., Mid-Infrared Microspectroscopic Imaging with a Quantum Cascade Laser. Next-Generation Spectroscopic Technologies VI 2013, 8726, DOI: 10.1117/12.2015984.

  • 2012
    • Ambekar, R.; Lau, T. Y.; Walsh, M.; Bhargava, R.; Toussaint, K. C., Quantifying Collagen Structure in Breast Biopsies Using Second-Harmonic Generation Imaging. Biomedical Optics Express 2012, 3, (9), 2021-2035.

    • Bhargava, R., Infrared Spectroscopic Imaging: The Next Generation. Applied Spectroscopy 2012, 66, (10), 1091-1120.

    • Kole, M. R.; Reddy, R. K.; Schulmerich, M. V.; Gelber, M. K.; Bhargava, R., Discrete Frequency Infrared Microspectroscopy and Imaging with a Tunable Quantum Cascade Laser. Analytical Chemistry 2012, 84, (23), 10366-10372.

    • Lu, N. X.; Mylon, S. E.; Kong, R.; Bhargava, R.; Zilles, J. L.; Nguyen, T. H., Interactions between Dissolved Natural Organic Matter and Adsorbed DNA and Their Effect on Natural Transformation of Azotobacter Vinelandii. Science of the Total Environment 2012, 426, 430-435.

    • Odom, S. A.; Tyler, T. P.; Caruso, M. M.; Ritchey, J. A.; Schulmerich, M. V.; Robinson, S. J.; Bhargava, R.; Sottos, N. R.; White, S. R.; Hersam, M. C.; Moore, J. S., Autonomic Restoration of Electrical Conductivity Using Polymer-Stabilized Carbon Nanotube and Graphene Microcapsules. Applied Physics Letters 2012, 101, (4).

    • Schulmerich, M. V.; Walsh, M. J.; Gelber, M. K.; Kong, R.; Kole, M. R.; Harrison, S. K.; McKinney, J.; Thompson, D.; Kull, L. S.; Bhargava, R., Protein and Oil Composition Predictions of Single Soybeans by Transmission Raman Spectroscopy. Journal of Agricultural and Food Chemistry 2012, 60, (33), 8097-8102.

    • Walsh, M. J.; Reddy, R. K.; Bhargava, R., Label-Free Biomedical Imaging with Mid-IR Spectroscopy. IEEE Journal of Selected Topics in Quantum Electronics 2012, 18, (4), 1502-1513.

    • Bhargava, R., Resolution in Mid-Infrared Imaging: The Theory. Spectroscopy 2012, 27, (2), 74-74.

    • Kwak, J. T.; Reddy, R.; Sinha, S.; Bhargava, R., Analysis of Variance in Spectroscopic Imaging Data from Human Tissues. Analytical Chemistry 2012, 84, (2), 1063-1069.

    • Kwon, B.; Rosenberger, M.; Bhargava, R.; Cahill, D. G.; King, W. P., Dynamic Thermomechanical Response of Bimaterial Microcantilevers to Periodic Heating by Infrared Radiation. Review of Scientific Instruments 2012, 83, DOI: 10.1063/1.3680107.

    • Kwon, B.; Schulmerich, M. V.; Elgass, L. J.; Kong, R.; Holton, S. E.; Bhargava, R.; King, W. P., Infrared Microspectroscopy Combined with Conventional Atomic Force Microscopy. Ultramicroscopy 2012, 116, 56-61.

    • Mahr, D. M.; Bhargava, R.; Insana, M. F., Three-Dimensional in Silico Breast Phantoms for Multimodal Image Simulations. IEEE Transactions on Medical Imaging 2012, 31, (3), 689-697.

    • Walsh, M. J.; Kajdacsy-Balla, A.; Bhargava, R., Mid-Infrared Spectroscopic Imaging for Tissue Histopathology. Laboratory Investigation 2012, 92, 518A-518A.

  • 2011
    • Yao, J. M.; Le, A. P.; Schulmerich, M. V.; Maria, J.; Lee, T. W.; Gray, S. K.; Bhargava, R.; Rogers, J. A.; Nuzzo, R. G., Soft Embossing of Nanoscale Optical and Plasmonic Structures in Glass. ACS Nano 2011, 5, (7), 5763-5774.

    • Yao, J. M.; Le, A. P.; Schulmerich, M. V.; Maria, J.; Lee, T. W.; Gray, S. K.; Bhargava, R.; Rogers, J. A.; Nuzzo, R. G., Soft Embossing of Nanoscale Optical and Plasmonic Structures in Glass. Acs Nano 2011, 5, (7), 5763-5774.

    • Liu, J. N.; Schulmerich, M. V.; Bhargava, R.; Cunningham, B. T., Optimally Designed Narrowband Guided-Mode Resonance Reflectance Filters for Mid-Infrared Spectroscopy. Optics Express 2011, 19, (24), 24182-24197.

    • Chanda, D.; Shigeta, K.; Truong, T.; Lui, E.; Mihi, A.; Schulmerich, M.; Braun, P. V.; Bhargava, R.; Rogers, J. A., Coupling of Plasmonic and Optical Cavity Modes in Quasi-Three-Dimensional Plasmonic Crystals. Nature Communications 2011, 2, DOI: 10.1038/ncomms1487.

    • Holton, S. E.; Walsh, M. J.; Bhargava, R., Subcellular Localization of Early Biochemical Transformations in Cancer-Activated Fibroblasts Using Infrared Spectroscopic Imaging. Analyst 2011, 136, (14), 2953-2958.

    • Kodali, A. K.; Bhargava, R., Effect of Non-Specificity in Shape, Size, and Dielectric Properties on Electromagnetic Extinction and Optical Field Enhancement from Spherical Nanolayered Metal-Dielectric Particles. Theoretical Chemistry Accounts 2011, 130, (4-6), 991-1000.

    • Kong, R.; Bhargava, R., Characterization of porcine skin as a model for human skin studies using infrared spectroscopic imaging. Analyst 2011, 136, (11), 2359-2366.

    • Kwak, J. T.; Hewitt, S. M.; Sinha, S.; Bhargava, R., Multimodal microscopy for automated histologic analysis of prostate cancer. BMC Cancer 2011, 11.

    • Nasse, M. J.; Walsh, M. J.; Mattson, E. C.; Reininger, R.; Kajdacsy-Balla, A.; Macias, V.; Bhargava, R.; Hirschmugl, C. J., High-resolution Fourier-transform infrared chemical imaging with multiple synchrotron beams. Nature Methods 2011, 8, (5), 413-416.

    • Kwon, B.; Wang, C.; Park, K.; Bhargava, R.; King, W. P., Thermomechanical Sensitivity of Microcantilevers in the Mid-Infrared Spectral Region. Nanoscale and Microscale Thermophysical Engineering 2011, 15, (1), 16-27.

    • Davis, B. J.; Carney, P. S.; Bhargava, R., Theory of Infrared Microspectroscopy for Intact Fibers. Analytical Chemistry 2011, 83, (2), 525-532.

    • Walsh, M. J.; Mayerich, D. M.; Wiley, E. L.; Kajdacsy-Balla, A.; Bhargava, R., Mid-Infrared Spectroscopic Imaging for Breast Tissue Histopathology: Towards 'Stainless Staining'. Modern Pathology 2011, 24, 1941.

  • 2010
    • Kodali, A. K.; Llora, X.; Bhargava, R., Optimally designed nanolayered metal-dielectric particles as probes for massively multiplexed and ultrasensitive molecular assays. Proceedings of the National Academy of Sciences of the United States of America 2010, 107, (31), 13620-13625.

    • Kodali, A. K.; Schulmerich, M.; Ip, J.; Yen, G.; Cunningham, B. T.; Bhargava, R., Narrowband Midinfrared Reflectance Filters Using Guided Mode Resonance. Analytical Chemistry 2010, 82, (13), 5697-5706.

    • Kodali, A. K.; Schulmerich, M. V.; Palekar, R.; Llora, X.; Bhargava, R., Optimized nanospherical layered alternating metal-dielectric probes for optical sensing. Optics Express 2010, 18, (22), 23302-23313.

    • Davis, B. J.; Carney, P. S.; Bhargava, R., Theory of Midinfrared Absorption Microspectroscopy: I. Homogeneous Samples. Analytical Chemistry 2010, 82, (9), 3474-3486.

    • Davis, B. J.; Carney, P. S.; Bhargava, R., Theory of Mid-infrared Absorption Microspectroscopy: II. Heterogeneous Samples. Analytical Chemistry 2010, 82, (9), 3487-3499.

    • Kong, R.; Reddy, R. K.; Bhargava, R., Characterization of Tumor Progression in Engineered Tissue using Infrared Spectroscopic Imaging. Analyst 2010, 135, 1569 - 1578.

    • Reddy, R. K.; Bhargava, R., Accurate histopathology from low signal-to-noise ratio spectroscopic imaging data. Analyst 2010, 135, (11), 2818-2825.

    • Schulmerich, M. V.; Reddy, R.; Kodali, A. K.; Elgass, L. J.; Tangella, K.; Bhargava, R., Dark Field Raman Microscopy. Analytical Chemistry 2010, 82, (14), 6273-6280.

  • 2009
    • Llora, X.; Priya, A.; Bhargava , R., Observer-Invariant Histopathology using Genetics-Based Machine Learning. Natural Computing 2009, 8, 101-120.

    • Bhargava, R., Special Issue: Prominent Young Vibrational Spectroscopists 2009 Preface. Vibrational Spectroscopy 2009, 50, (1), 1-1.

    • Bhargava, R.; Perlman, R. S.; Fernandez, D. C.; Levin , I. W.; Bartick, E. G., Non-invasive detection of superimposed latent fingerprints and inter-ridge trace evidence by infrared spectroscopic imaging. Analytical and Bioanalytical Chemistry 2009, 394, (8), 2069-2075.

  • 2008
    • Park, K.; Lee, J.; Bhargava, R.; King, W. P., Routine femtogram-level chemical analyses using vibrational spectroscopy and self-cleaning scanning probe microscopy tips. Analytical Chemistry 2008, 80, (9), 3221-3228.

  • 2007
    • Srinivasan, G.; Bhargava, R., Fourier transform-infrared spectroscopic imaging: The emerging evolution from a microscopy tool to a cancer imaging modality. Spectroscopy 2007, 22, (7), 30-31.

    • Bhargava, R.; Hewitt, S. M.; Levin, I. W. Re:Unrealistic expectations for IR microspectroscopic imaging. Nature Biotechnology 2007, 25, 31-33.

    • Bhargava, R., Towards a practical fourier transform infrared chemical imaging protocol for cancer histopathology. Analytical and Bioanalytical Chemistry 2007, 389, (4), 1155-1169.

  • 2006
    • Bhargava, R.; Fernandez, D. C.; Hewitt, S. M.; Levin, I. W. High throughput assessment of cells and tissues: Bayesian classification of spectral metrics from infrared vibrational spectroscopic imaging data. Biochimica Et Biophysica Acta-Biomembranes 2006, 1758, (7), 830-845.

  • 2005
    • Fernandez, D. C.; Bhargava, R.; Hewitt, S. M.; Levin, I. W. Infrared Spectroscopic Imaging for Observer-invariant Histopathology. Nature Biotechnology 2005, 23, 469-474.

    • Levin, I. W., Bhargava, R. Fourier Transform Infrared Vibrational Spectroscopic Imaging: Integration of Microscopy and Molecular Recognition. Annu. Rev. Phys. Chem. 2005, 56, 429-474.

  • 2004
    • Bhargava, R., Levin, I. W. (2004), "Probing the Structure and Dynamics of Macromolecular Composites by Infrared Spectroscopy and Imaging," Vibrational Spectroscopy, 34, 13-24.

  • 2003
    • Bhargava, R., Wang, S. Q., Koenig, J. L. (2003), "FTIR Microspectroscopy of Polymeric Systems," Advances in Polymer Science, 163, 137-191.

    • Bhargava, R., Levin, I. W. (2003), "Non-invasive Imaging of Molecular Dynamics in Heterogeneous Materials" Macromolecules, 36, 92-96.

  • 2001
    • Bhargava, R., Levin, I. W. (2001), "FTIR imaging: Theory and Practice," Analytical Chemistry, 73, 5157-5167.

Press

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