Stephen Boppart

Description

Address

  • 4351 Beckman Institute
  • 405 North Mathews Avenue
  • Urbana, Illinois 61801

Biography

Prof. Boppart heads the Biophotonics Imaging Laboratory at the Beckman Institute and is a full-time faculty member in the Bioimaging Science and Technology group. His home departments are Electrical and Computer Engineering and Bioengineering, with affiliations with the Department of Internal Medicine in the College of Medicine, the Micro and Nanotechnology Laboratory, and the Institute for Genomic Biology. Prof. Boppart received his PhD in Electrical and Medical Engineering from MIT in 1998 and his MD from Harvard Medical School in 2000. Currently he combines his optical imaging and biophotonics research and teaching with clinical research in novel medical technologies.

Honors

Visiting Professorship, Raine Medical Research Foundation, Australia (2008); Engineering Council Award for Excellence in Advising (2006, 2007); IEEE Engineering in Medicine and Biology Society Early Career Achievement Award (2005); College of Engineering Everitt Award for Teaching Excellence (2005, 2003); National Science Foundation CAREER Award (2004); Technology Review Magazine's Top 100 Young Innovator in the World (2002); Xerox Faculty Award for Outstanding Research (2002); Whitaker Foundation Fellow (2001); Resident Physician Research Award, College of Medicine, UIUC (2001); Young Faculty Award, American Association of Anatomists (2001).

Research

Prof. Stephen Boppart is interested in using light to image biological tissue and diagnose disease. Using advanced imaging techniques such as optical coherence tomography (OCT), nonlinear interferometric vibrational imaging (NIVI), interferometric synthetic aperture microscopy (ISAM), and multi-photon microscopy, it is feasible to generate high-resolution, real-time, non-invasive images of biological tissue at the cellular and molecular level for diagnosing diseases such as cancer. As imaging trends progress to the molecular level, the origin of virtually all disease processes, the ability to image or map the location of endogenous molecules or exogenous molecularly-targeted contrast agents will become important for diagnosis. Prof. Boppart's research spans a wide range of novel optical technologies, systems, methods, and applications including molecular imaging, novel contrast agents for OCT, functional OCT for imaging neural activity and physiological parameters, and multi-modality optical imaging techniques for tracking the growth and development of engineering tissues, tumors, and biological specimens. Prof. Boppart also has translated many of these optical diagnostic technologies into clinical studies with several ongoing patient trials at local medical institutions.

Publications

  • 2014
    • Crecea, V.; Graf, B. W.; Kim, T.; Popescu, G.; Boppart, S. A., High Resolution Phase-Sensitive Magnetomotive Optical Coherence Microscopy for Tracking Magnetic Microbeads and Cellular Mechanics. IEEE Journal of Selected Topics in Quantum Electronics 2014, 20, (2), DOI: 10.1109/jstqe.2013.2280501.

    • Erickson-Bhatt, S. J.; Nolan, R.; Shemonski, N. D.; Adie, S. G.; Putney, J.; Darga, D.; McCormick, D. T.; Cittadine, A.; Marjanovic, M.; Chaney, E. J.; Monroy, G. L.; South, F.; Carney, P. S.; Cradock, K. A.; Liu, Z. G.; Ray, P. S.; Boppart, S. A., In Vivo Intra-Operative Breast Tumor Margin Detection Using a Portable Oct System with a Handheld Surgical Imaging Probe, In Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems Xii. VoDinh, T., MahadevanJansen, A., Grundfest, W. S., Eds.; Spie-Int Soc Optical Engineering, Bellingham, 2014; Vol. 8935.

    • Graf, B. W.; Bower, A. J.; Chaney, E. J.; Marjanovic, M.; Adie, S. G.; De Lisio, M.; Valero, M. C.; Boppart, M. D.; Boppart, S. A., In Vivo Multimodal Microscopy for Detecting Bone-Marrow-Derived Cell Contribution to Skin Regeneration. Journal of Biophotonics 2014, 7, (1-2), 96-102, DOI: 10.1002/jbio.201200240.

    • Kim, J.; Ahmad, A.; Marjanovic, M.; Chaney, E. J.; Hubler, Z.; Rasio, J.; Li, J.; Suslick, K. S.; Boppart, S. A., Localization of Atherosclerotic Lesions Using Targeted Magnetic Microspheres and Magnetomotive Optical Coherence Tomography. Molecular Imaging and Biology 2014, 16, 36-43.

    • Kim, J.; Ahmad, A.; Marjanovic, M.; Chaney, E. J.; Li, J.; Rasio, J.; Hubler, Z.; Spillman, D.; Suslick, K. S.; Boppart, S. A., Magnetomotive Optical Coherence Tomography for the Assessment of Atherosclerotic Lesions Using Alpha(V)Beta(3) Integrin-Targeted Microspheres. Molecular Imaging and Biology 2014, 16, (1), 36-43, DOI: 10.1007/s11307-013-0671-6.

    • Monroy, G. L.; Shemonski, N. D.; Shelton, R. L.; Nolan, R. M.; Boppart, S. A., Implementation and Evaluation of Google Glass for Visualizing Real-Time Image and Patient Data in the Primary Care Office, In Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems Xii. VoDinh, T., MahadevanJansen, A., Grundfest, W. S., Eds.; Spie-Int Soc Optical Engineering, Bellingham, 2014; Vol. 8935.

    • Shelton, R. L.; Jung, W.; Sayegh, S. I.; McCormick, D. T.; Kim, J.; Boppart, S. A., Optical Coherence Tomography for Advanced Screening in the Primary Care Office. Journal of Biophotonics 2014, 7, 525-533, DOI: 10.1002/jbio.201200243.

    • Tu, H. H.; Boppart, S. A., Coherent Anti-Stokes Raman Scattering Microscopy: Overcoming Technical Barriers for Clinical Translation. Journal of Biophotonics 2014, 7, (1-2), 9-22, DOI: 10.1002/jbio.201300031.

    • Tu, H. H.; Zhao, Y. B.; Liu, Y.; Boppart, S. A., Static Third-Harmonic Lines in Widely Variable Fiber Continuum Generation. Physical Review A 2014, 89, (1), DOI: 10.1103/PhysRevA.89.013813.

    • Xu, Y.; Chng, X. K. B.; Adie, S. G.; Boppart, S. A.; Carney, P. S., Multifocal Interferometric Synthetic Aperture Microscopy. Optical Express 2014, 22, 1660616618.

  • 2013
    • Ahmad, A.; Shemonski, N. D.; Adie, S. G.; Kim, H. S.; Hwu, W. M. W.; Carney, P. S.; Boppart, S. A., Real-Time in Vivo Computed Optical Interferometric Tomography. Nature Photonics 2013, 7, (6), 445-449, DOI: 10.1038/nphoton.2013.71.

    • Boulos, S. P.; Prigozhin, M. B.; Liu, Y.; Wirth, A. J.; Boppart, S. A.; Gruebele, M.; Murphy, C. J., The Gold Nanorod-Biology Interface: From Proteins to Cells to Tissue. Current Physical Chemistry 2013, 3, 128-135.

    • Carney, P. S.; Adie, S. G.; Boppart, S. A., Interferometric Synthetic Aperture Microscopy, In Emerging Imaging Technologies in Medicine. Anastasio, M. A., LaRiviere, P., Eds.; CRC Press, 2013, Ch. 19, 293-301.

    • Cha, C.; Antoniadou, E.; Lee, M.; Jeong, J. H.; Ahmed, W. W.; Saif, T. A.; Boppart, S. A.; Kong, H., Tailoring Hydrogel Adhesion to Polydimethylsiloxane Substrates Using Polysaccharide Glue. Angewandte Chemie-International Edition 2013, DOI: 10.1002/ange.201302925.

    • Crecea, V.; Ahmad, A.; Boppart, S. A., Magnetomotive Optical Coherence Elastography for Microrheology of Biological Tissues. Journal of Biomedical Optics 2013, 18, (12), DOI: 10.1117/1.jbo.18.12.121504.

    • Graf, B. W.; Chaney, E. J.; Marjanovic, M.; Adie, S. G.; De Lisio, M.; Valero, M. C.; Boppart, M. D.; Boppart, S. A., Long-Term Time-Lapse Multimodal Intravital Imaging of Regeneration and Bone-Marrow-Derived Cell Dynamics in Skin. Technology 2013, 1, 1-12.

    • Graf, B. W.; Chaney, E. J.; Marjanovic, M.; De Lisio, M.; Valero, M. C.; Boppart, M. D.; Boppart, S. A., In Vivo Imaging of Immune Cell Dynamics in Skin in Response to Zinc-Oxide Nanoparticle Exposure. Biomedical Optics Express 2013, 4, (10), 1817-1828, DOI: 10.1364/boe.4.001817.

    • Janjaroen, D.; Ling, F. Q.; Monroy, G.; Derlon, N.; Mogenroth, E.; Boppart, S. A.; Liu, W. T.; Nguyen, T. H., Roles of Ionic Strength and Biofilm Roughness on Adhesion Kinetics of Escherichia Coli onto Groundwater Biofilm Grown on PVC Surfaces. Water Research 2013, 47, (7), 2531-2542, DOI: 10.1016/j.watres.2013.02.032.

    • Jeong, J. H.; Liang, Y.; Jang, M.; Cha, C.; Chu, C.; Lee, H.; Jung, W.; Kim, J. W.; Boppart, S. A.; Kong, H., Stiffness-Modulated Water Retention and Neovascularization of Dermal Fibroblast-Encapsulating Collagen Gel. Tissue Engineering Part A 2013, 19, (11-12), 1275-1284, DOI: 10.1089/ten.tea.2012.0230.

    • John, R.; Adie, S. G.; Chaney, E. J.; Marjanovic, M.; Tangella, K. V.; Boppart, S. A., Three-Dimensional Optical Coherence Tomography for Optical Biopsy of Lymph Nodes and Assessment of Metastatic Disease. Annals of Surgical Oncology 2013, 20, (11), 3685-3693, DOI: 10.1245/s10434-012-2434-z.

    • Jung, W.; Boppart, S. A., Optical Coherence Tomography for Rapid Tissue Screening and Directed Histological Sectioning. Biophotonics in Pathology: Pathology at the Crossroads 2013, 185, 109-128, DOI: 10.3233/978-1-61499-234-9-109.

    • Kim, J.; Ahmad, A.; Boppart, S. A., Dual-Coil Magnetomotive Optical Coherence Tomography for Contrast Enhancement in Liquids. Optics Express 2013, 21, (6), 7139-7147.

    • Liu, X. M.; Villanueva, G. E.; Laegsgaard, J.; Moller, U.; Tu, H. H.; Boppart, S. A.; Turchinovich, D., Low-Noise Operation of All-Fiber Femtosecond Cherenkov Laser. IEEE Photonics Technology Letters 2013, 25, (9), 892-895, DOI: 10.1109/lpt.2013.2253765.

    • Liu, Y.; King, M. D.; Tu, H. H.; Zhao, Y. B.; Boppart, S. A., Broadband Nonlinear Vibrational Spectroscopy by Shaping a Coherent Fiber Supercontinuum. Optics Express 2013, 21, (7), 8269-8275.

    • Lu, S. Y.; Wang, Y.; Huang, H.; Pan, Y. J.; Chaney, E. J.; Boppart, S. A.; Ozer, H.; Strongin, A. Y.; Wang, Y. X., Quantitative Fret Imaging to Visualize the Invasiveness of Live Breast Cancer Cells. Plos One 2013, 8, (3).

    • Nguyen, C. T.; Robinson, S. R.; Jung, W.; Novak, M. A.; Boppart, S. A.; Allen, J. B., Investigation of Bacterial Biofilm in the Human Middle Ear Using Optical Coherence Tomography and Acoustic Measurements. Hearing Research 2013, 301, 193-200, DOI: 10.1016/j.heares.2013.04.001.

    • Shelton, R.; Jung, W.; Sayegh, S. I.; McCormick, D. T.; Kim, J.; Boppart, S. A., Optical Coherence Tomography for Advanced Screening in the Primary Care Office. Journal of Biophotonics 2013, DOI: 10.1002/jbio.201300031.

    • Sun, J. G.; Adie, S. G.; Chaney, E. J.; Boppart, S. A., Segmentation and Correlation of Optical Coherence Tomography and X-Ray Images for Breast Cancer Diagnostics. Journal of Innovative Optical Health Sciences 2013, 6, (2).

    • Tu, H. H.; Boppart, S. A., Coherent Fiber Supercontinuum for Biophotonics. Laser & Photonics Reviews 2013, 7, (5), 628-645, DOI: 10.1002/lpor.201200014.

    • Tu, H. H.; Laegsgaard, J.; Zhang, R.; Tong, S.; Liu, Y.; Boppart, S. A., Bright Broadband Coherent Fiber Sources Emitting Strongly Blue-Shifted Resonant Dispersive Wave Pulses. Optics Express 2013, 21, (20), 23188-23196, DOI: 10.1364/oe.21.023188.

    • Tu, H.; Boppart, S. A., Coherent Anti-Stokes Raman Scattering Microscopy: Overcoming Technical Barriers for Clinical Translation. Journal of Biophotonics 2013, DOI: 10.1002/jbio.201300031.

    • Wang, R. K. K.; Sampson, D. D.; Boppart, S. A.; Kennedy, B. F., Optical Elastography and Measurement of Tissue Biomechanics. Journal of Biomedical Optics 2013, 18, (12), DOI: 10.1117/1.jbo.18.12.121501.

    • Wang, Y.; Shemonski, N. D.; Adie, S. G.; Boppart, S. A.; Insana, M. F. Dynamic Method of Optical Coherence Elastography in Determining Viscoelasticity of Polymers and Tissues, Conference Proceedings from IEEE Engineering in Medicine and Biology Society,  Osaka, Japan, July 3-7, 2013, 117-120.

    • Zhao, Y. B.; Bower, A. J.; Graf, B. W.; Boppart, M. D.; Boppart, S. A., Imaging and Tracking of Bone Marrow-Derived Immune and Stem Cells, In Imaging and Tracking Stem Cells: Methods and Protocols. Turksen, K., Ed.; Humana Press Inc, Totowa, 2013; Vol. 1052, Ch. 28, 57-76.

  • 2012
    • Adie, S. G.; Graf, B. W.; Ahmad, A.; Carney, P. S.; Boppart, S. A., Computational Adaptive Optics for Broadband Optical Interferometric Tomography of Biological Tissue. Proceedings of the National Academy of Sciences of the United States of America 2012, 109, (19), 7175-7180.

    • Benalcazar, W.; Boppart, S. A., Optical Coherence Imaging for Surgical Pathology Assessment, In Handbook of Biophotonics, Volume 2: Photonics for Health Care; Popp, J., Tuchin, V. V., Chiou, A., Heinemann, S., Eds.; Wiley-VCH, Verlag GmbH & Co., 2012, Ch. 13, 215-224.

    • Benalcazar, W. A.; Jung, W.; Boppart, S. A., Aberration Characterization for the Optimal Design of High-Resolution Endoscopic Optical Coherence Tomography Catheters. Optics Letters 2012, 37, (6), 1100-1102.

    • John, R.; Nguyen, F. T.; Kolbeck, K. J.; Chaney, E. J.; Marjanovic, M.; Suslick, K. S.; Boppart, S. A., Targeted Multifunctional Multimodal Protein-Shell Microspheres as Cancer Imaging Contrast Agents. Molecular Imaging and Biology 2012, 14, (1), 17-24.

    • Jung, W.; Boppart, S. A., Optical Coherence Tomography for Rapid Tissue Screening and Directed Histological Sectioning. Analytical Cellular Pathology 2012, 35, (3), 129-143.

    • Kuo, W.-C.; Kim, J.; Shemonski, N. D.; Chaney, E. J.; Spillman, D. R.; Boppart, S. A., Real-Time Three-Dimensional Optical Coherence Tomography Image-Guided Core-Needle Biopsy System. Biomedical Optics Express 2012, 3, 1141-1148.

    • Liu, Y.; Tu, H.; Benalcazar, W. A.; Chaney, E. J.; Boppart, S. A., Multimodal Nonlinear Microscopy by Shaping a Fiber Supercontinuum from 900 to 1160 Nm. IEEE Journal of Selected Topics in Quantum Mechanics – Biophotonics I 2012, 18, 1209-1214.

    • Liu, Y.; Tu, H.; Boppart, S. A., Wave-Breaking-Extended Fiber Supercontinuum Generation for High Compression-Ratio Transform-Limited Pulse Compression. Optics Letters 2012, 37, 2171-2174.

    • Tu, H.; Liu, Y.; Laegsgaard, J.; Turchinovich, D.; Siegel, M.; Kopf, D.; Li, H.; Gunaratne, T.; Boppart, S. A., Cross-Validation of Theoretically Quantified Fiber Continuum Generation and Absolute Pulse Measurement by MIIPS for a Broadband Coherently Controlled Optical Source. Applied Physics B-Lasers and Optics 2012, 106, (2), 379-384.

    • Tu, H. H.; Liu, Y.; Liu, X. M.; Turchinovich, D.; Laegsgaard, J.; Boppart, S. A., Nonlinear Polarization Dynamics in a Weakly Birefringent All-Normal Dispersion Photonic Crystal Fiber: Toward a Practical Coherent Fiber Supercontinuum Laser. Optics Express 2012, 20, (2), 1113-1128.

    • Zhao, Y. B.; Graf, B. W.; Chaney, E. J.; Mahmassani, Z.; Antoniadou, E.; DeVolder, R.; Kong, H.; Boppart, M. D.; Boppart, S. A., Integrated Multimodal Optical Microscopy for Structural and Functional Imaging of Engineered and Natural Skin. Journal of Biophotonics 2012, 5, (5-6), 437-448.

    • Adie, S. G.; Shemonski, N. D.; Graf, B. W.; Ahmad, A.; Carney, P. S.; Boppart, S. A., Guide-Star-Based Computational Adaptive Optics for Broadband Interferometric Tomography. Applied Physics Letters 2012, 101, (22).

    • Boppart, S. A., Visualizing Middle-Ear Biofilms in Otitis Media: A New Benchmark for Successful Treatment. ENT and Audiology News 2012, 21, 94-95.

    • Graf, B. W.; Boppart, S. A., Multimodal in Vivo Skin Imaging with Integrated Optical Coherence and Multiphoton Microscopy. IEEE Journal of Selected Topics in Quantum Electronics 2012, 18, (4), 1280-1286.

    • Ilev, I. K.; Boppart, S. A.; Andersson-Engels, S.; Kim, B. M.; Vo-Dinh, T., Introduction to the Issue on Biophotonics-Part 1. IEEE Journal of Selected Topics in Quantum Electronics 2012, 18, (3), 1039-1041.

    • Ilev, I. K.; Boppart, S. A.; Andersson-Engels, S.; Kim, B. M.; Vo-Dinh, T., Introduction to the Issue on Biophotonics-Part 2. IEEE Journal of Selected Topics in Quantum Electronics 2012, 18, (4), 1267-1269.

    • Liu, X. M.; Laegsgaard, J.; Moller, U.; Tu, H. H.; Boppart, S. A.; Turchinovich, D., All-Fiber Femtosecond Cherenkov Radiation Source. Optics Letters 2012, 37, (13), 2769-2771.

    • Nguyen, C. T.; Jung, W.; Kim, J.; Chaney, E. J.; Novak, M.; Stewart, C. N.; Boppart, S. A., Noninvasive in Vivo Optical Detection of Biofilm in the Human Middle Ear. Proceedings of the National Academy of Sciences of the United States of America 2012, 109, (24), 9529-9534.

    • Tu, H.; Boppart, S. A., Coherent Fiber Supercontinuum and Non-Supercontinuum Sources for Portable Biophotonics. Laser & Photonics Review 2012, DOI: 10.1002/lpor.201200014.

  • 2011
    • Liang, X.; Graf, B. W.; Boppart, S. A., In Vivo Multiphoton Microscopy for Investigating Biomechanical Properties of Human Skin. Cellular and Molecular Bioengineering 2011, 4, (2), 231-238.

    • Jung, W.; Kim, J.; Jeon, M.; Chaney, E. J.; Stewart, C. N.; Boppart, S. A., Handheld Optical Coherence Tomography Scanner for Primary Care Diagnostics. IEEE Transactions on Biomedical Engineering 2011, 58, (3), 741-744.

    • Kennedy, B. F.; Liang, X.; Adie, S. G.; Gerstmann, D. K.; Quirk, B. C.; Boppart, S. A.; Sampson, D. D., In vivo three-dimensional optical coherence elastography. Optics Express 2011, 19, (7), 6623-6634.

    • Benalcazar, W. A.; Boppart, S. A., Nonlinear interferometric vibrational imaging for fast label-free visualization of molecular domains in skin. Analytical and Bioanalytical Chemistry 2011, 400, (9), 2817-2825.

    • Chaney, E. J.; Nguyen, C. T.; Boppart, S. A., Novel method for non-invasive induction of a middle-ear biofilm in the rat. Vaccine 2011, 29, (8), 1628-1633.

    • Jeon, M.; Kim, J.; Jung, U.; Lee, C.; Jung, W.; Boppart, S. A., Full-range k-domain linearization in spectral-domain optical coherence tomography. Applied Optics 2011, 50, (8), 1158-1163.

    • John, R.; Boppart, S. A., Magnetomotive Molecular Nanoprobes. Current Medicinal Chemistry 2011, 18, (14), 2103-2114.

  • 2010
    • Jung, W.; Benalcazar, W.; Ahmad, A.; Sharma, U.; Tu, H.; Boppart, S. A., Numerical analysis of gradient index lens-based optical coherence tomography imaging probes. Journal of Biomedical Optics 2010, 15, (6).

    • John, R.; Boppart, S. A., Scattering, absorbing, and modulating nanoprobes for coherence imaging. In Nanobiophotonics, Popescu, G., Ed. McGraw-Hill: 2010.

    • Oldenburg, A. L.; Boppart, S. A., Resonant acoustic spectroscopy of soft tissues using embedded magnetomotive nanotransducers and optical coherence tomography. Physics in Medicine and Biology 2010, 55, (4), 1189-1201.

    • Benalcazar, W. A.; Chowdary, P. D.; Jiang, Z.; Marks, D. L.; Chaney, E. J.; Gruebele, M.; Boppart, S. A., High-Speed Nonlinear Interferometric Vibrational Imaging of Biological Tissue With Comparison to Raman Microscopy. IEEE Journal of Selected Topics in Quantum Electronics 2010, 16, (4), 824-832. 

    • Chowdary, P. D.; Jiang, Z.; Chaney, E. J.; Benalcazar, W. A.; Marks, D. L.; Gruebele, M.; Boppart, S. A., Molecular Histopathology by Spectrally Reconstructed Nonlinear Interferometric Vibrational Imaging. Cancer Research 2010, 70, (23), 9562-9569. 

    • Adie, S. G.; Liang, X.; Kennedy, B. F.; John, R.; Sampson, D. D.; Boppart, S. A., Spectroscopic optical coherence elastography. Optics Express 2010, 18, (25), 25519-25534.

    • Chowdary, P. D.; Jiang, Z.; Chaney, E. J.; Benalcazar, W. A.; Marks, D. L.; Gruebele, M.; Boppart, S. A., Molecular Histopathology by Spectrally Reconstructed Nonlinear Interferometric Vibrational Imaging. Cancer Research 2010, 70, (23), 9562-9569.

    • Ding, H. F.; Wang, Z.; Nguyen, F. T.; Boppart, S. A.; Millet, L. J.; Gillette, M. U.; Liu, J. M.; Boppart, M. D.; Popescu, G., Fourier Transform Light Scattering (FTLS) of Cells and Tissues. Journal of Computational and Theoretical Nanoscience 2010, 7, (12), 2501-2511.

    • Graf, B. W.; Adie, S. G.; Boppart, S. A., Correction of coherence gate curvature in high numerical aperture optical coherence imaging. Optics Letters 2010, 35, (18), 3120-3122.

    • Graf, B. W.; Boppart, S. A., Imaging and analysis of three-dimensional cell culture models. In Methods in Molecular Biology: Live Cell Imaging, Papkovsky, D., Ed. Humana Press: 2010; Vol. 591, pp 211-227.

    • Graf, B. W.; Chaney, E. J.; Valero, M. C.; Marjanovic, M.; Boppart, M. D.; Boppart, S. A. Long-term, time-lapse, multi-modal microscopy for tracking cell dynamics in live tissue, Proceedings of SPIE – The International Society for Optics and Photonics, 2010.

    • Ilev, I. K.; Wang, L. V.; Boppart, S. A.; Andersson-Engels, S.; Kim, B. M., Introduction to the Special Issue on Biophotonics - Part 2. IEEE Journal of Selected Topics in Quantum Electronics 2010, 16, (4), 703-705.

    • Jiang, Z.; Leaird, D. E.; Long, C. M.; Boppart, S. A.; Weiner, A. M., Optical arbitrary waveform characterization using linear spectrograms. Optics Communications 2010, 283, 3017-3021.

    • John, R.; Chaney, E. J.; Boppart, S. A., Dynamics of magnetic nanoparticle-based contrast agents in tissues tracked using magnetomotive optical coherence tomography. IEEE Journal of Selected Topics in Quantum Electronics 2010,16, 691-697.

    • John, R.; Rezaeipoor, R.; Adie, S. G.; Chaney, E. J.; Oldenburg, A. L.; Marjanovic, M.; Haldar, J. P.; Sutton, B. P.; Boppart, S. A., In vivo magnetomotive optical molecular imaging using targeted magnetic nanoprobes. Proceedings of the National Academy of Sciences of the United States of America 2010, 107, (18), 8085-8090.

    • Liang, X.; Adie, S. G.; John, R.; Boppart, S. A., Dynamic spectral-domain optical coherence elastography for tissue characterization. Optics Express 2010, 18, 14183-14190.

    • Liang, X.; Boppart, S. A., Biomechanical Properties of In Vivo Human Skin From Dynamic Optical Coherence Elastography. IEEE Transactions on Biomedical Engineering 2010, 57, (4), 953-959.

    • Nguyen, F. T.; Zysk, A. M.; Chaney, E. J.; Adie, S. G.; Kotynek, J. G.; Oliphant, U. J.; Bellafiore, F. J.; Rowland, K. M.; Johnson, P. A.; Boppart, S. A., Optical Coherence Tomography The Intraoperative Assessment of Lymph Nodes in Breast Cancer. IEEE Engineering in Medicine and Biology Magazine 2010, 29, (2), 63-70.

    • Ralston, T. S.; Adie, S. G.; Marks, D. L.; Boppart, S. A.; Carney, P. S., Cross-validation of interferometric synthetic aperture microscopy and optical coherence tomography. Optics Letters 2010, 35, (10), 1683-1685.

    • Ralston, T. S.; Charvat, G. L.; Adie, S. G.; Davis, B. J.; Carney, P. S.; Boppart, S. A., Interferometric synthetic aperture microscopy: Microscopic laser radar. Optics and Photonics News 2010, 21, 32-38.

    • Ahmad, A.; Adie, S. G.; Wang, M.; Boppart, S. A., Sonification of optical coherence tomography data and images. Optics Express 2010, 18, (10), 9934-9944.

    • Boustany, N. N.; Boppart, S. A.; Backman, V., Microscopic imaging and spectroscopy with scattered light. Annual Review of Biomedical Engineering 2010, 12, 285-314.

    • Chaney, E. J.; Tang, L.; Tong, R.; Cheng, J.; Boppart, S. A., Lymphatic biodistribution of polylactide nanoparticles. Molecular Imaging 2010, 9, 153-162.

    • Chowdary, P. D.; Benalcazar, W. A.; Jiang, Z.; Marks, D. M.; Boppart, S. A.; Gruebele, M., High Speed Nonlinear Interferometric Vibrational Analysis of Lipids by Spectral Decomposition. Analytical Chemistry 2010, 82, (9), 3812-3818.

    • Liang, X.; Crecea, V.; Boppart, S. A., Dynamic optical coherence elastography: A review. J Innovative Optical Health Sciences 2010, 3, 221-233.

    • Nguyen, C. T.; Tu, H.; Chaney, E. J.; Stewart, C. N.; Boppart, S. A., Non-invasive optical interferometry for the assessment of biofilm growth in the middle ear. Biomedical Optics Express 2010, 1, 1104-1116.

    • Sharma, U.; Boppart, S. A., Optical low-coherence interferometric techniques for applications in nanomedicine. In Nanobiophotonics, Popescu, G., Ed. McGraw-Hill: 2010.

    • Shin, S.; Sharma, U.; Tu, H. H.; Jung, W.; Boppart, S. A., Characterization and Analysis of Relative Intensity Noise in Broadband Optical Sources for Optical Coherence Tomography. IEEE Photonics Technology Letters 2010, 22, (14), 1057-1059.

    • Tu, H.; Shin, S.; John, R.; Boppart, S. A., Long-period fiber gratings spontaneously written by a mechanism markedly different from Hill grating formation. Applied Physics Letters 2010, 97, (12).

    • Tu, H. H.; Liu, Y. A.; Laegsgaard, J.; Sharma, U.; Siegel, M.; Kopf, D.; Boppart, S. A., Scalar generalized nonlinear Schrodinger equation-quantified continuum generation in an all-normal dispersion photonic crystal fiber for broadband coherent optical sources. Optics Express 2010, 18, (26), 27872-27884.

  • 2009
    • Crecea, V.; Oldenburg, A. L.; Liang, X.; Ralston, T. S.; Boppart, S. A., Magnetomotive nanoparticle transducers for optical rheology of viscoelastic materials. Optics Express 2009, 17, (25), 23114-23122.

    • Geddes, J. B.; Marks, D. L.; Boppart, S. A., Design of matched optical pulses for coherent Raman imaging. Optics and Photonics News 2009, 20, (12), 31.

    • Graf, B.; Boppart, S. A., Intrinsic optical scattering changes correlated to electrical activity from single neurons. In SPIE Newsroom2009; Vol. 10.1117/2.1200909.1810.

    • Graf, B. W.; Jiang, Z.; Tu, H. H.; Boppart, S. A., Dual-spectrum laser source based on fiber continuum generation for integrated optical coherence and multiphoton microscopy. Journal of Biomedical Optics 2009, 14, (3).

    • Graf, B. W.; Ralston, T. S.; Ko, H. J.; Boppart, S. A., Detecting intrinsic scattering changes correlated to neuron action potentials using optical coherence imaging. Optics Express 2009, 17, (16), 13447-13457.

    • Marks, D. L.; Davis, B. J.; Boppart, S. A.; Carney, P. S., Partially coherent illumination in full-field interferometric synthetic aperture microscopy. Journal of the Optical Society of America a-Optics Image Science and Vision 2009, 26, (2), 376-386.

    • Nguyen, F. T.; Zysk, A. M.; Chaney, E. J.; Kotynek, J. G.; Oliphant, U. J.; Bellafiore, F. J.; Rowland, K. M.; Johnson, P. A.; Boppart, S. A., Optical coherence tomography (OCT) as a diagnostic tool for the real-time intraoperative assessment of breast cancer surgical margins. Cancer Research 2009, 69, (2), 101S-101S.

    • Rezaeipoor, R.; Chaney, E. J.; Oldenburg, A. L.; Boppart, S. A., Expression Order of Alpha-v and Beta-3 Integrin Subunits in the N-Methyl-N-Nitrosourea-Induced Rat Mammary Tumor Model. Cancer Investigation 2009, 27, (5), 496-503.

    • Tu, H.; Jiang, Z.; Marks, D. L.; Boppart, S. A., Intermodal four-wave mixing from femtosecond pulse-pumped photonic crystal fiber. Applied Physics Letters 2009, 94, (10).

    • Tu, H. H.; Liang, X.; Marks, D. L.; Boppart, S. A., Emergence of self-organized long-period fiber gratings in supercontinuum-generating optical fibers. Optics Letters 2009, 34, (5), 668-670.

    • Ahmad, A.; Adie, S. G.; Chaney, E. J.; Sharma, U.; Boppart, S. A., Cross-correlation-based image acquisition technique for manually-scanned optical coherence tomography. Optics Express 2009, 17, (10), 8125-8136.

    • Graf, B. W.; Jiang, Z.; Tu, H.; Boppart, S. A., Dual-spectrum laser source based on fiber continuum generation for integrated optical coherence and multiphoton microscopy. Journal of Biomedical Optics 2009, 14, 034019.

    • Rezaeipoor, R.; Chaney, E. J.; Oldenburg, A. L.; Boppart, S. A., Expression Order of Alpha-v and Beta-3 Integrin Subunits in the N-Methyl-N-Nitrosourea-Induced Rat Mammary Tumor Model. Cancer Investigation 2009, 27, (5), 496-503.

    • Rezaeipoor, R.; John, R.; Adie, S. G.; Chaney, E. J.; Marjanovic, M.; Oldenburg, A. L.; Rinne, S. A.; Boppart, S. A., Fc-directed antibody conjugation of magnetic nanoparticles for enhanced molecular targeting. Journal Innovative Optical Health Sciences 2009, 2, (4), 387-396.

    • Tu, H. H.; Boppart, S. A., Ultraviolet-visible non-supercontinuum ultrafast source enabled by switching single silicon strand-like photonic crystal fibers. Optics Express 2009, 17, (20), 17983-17988.

    • Tu, H. H.; Boppart, S. A., Targeted pulse-energy routing in fiber drives nonsupercontinuum applications. Laser Focus World 2009, 45, (7), 56-59.


    • Zysk, A. M.; Nguyen, F. T.; Chaney, E. J.; Kotynek, J. G.; Oliphant, U. J.; Bellafiore, F. J.; Johnson, P. A.; Rowland, K. M.; Boppart, S. A., Clinical Feasibility of Microscopically-Guided Breast Needle Biopsy Using a Fiber-Optic Probe with Computer-Aided Detection. Technology in Cancer Research & Treatment 2009, 8, (5), 315-321.

    • Nguyen, F. T.; Zysk, A. M.; Chaney, E. J.; Kotynek, J. G.; Oliphant, U. J.; Bellafiore, F. J.; Rowland, K. M.; Johnson, P. A.; Boppart, S. A., Intraoperative Evaluation of Breast Tumor Margins with Optical Coherence Tomography.Cancer Research 2009, 69, (22), 8790-8796.

    • Ding, H. F.; Nguyen, F.; Boppart, S. A.; Popescu, G., Optical properties of tissues quantified by Fourier-transform light scattering. Optics Letters 2009, 34, (9), 1372-1374.

    • Marks, D. L.; Geddes, J. B.; Boppart, S. A., Molecular identification by generating coherence between molecular normal modes using stimulated Raman scattering. Optics Letters 2009, 34, 1756-1758.

    • Tu, H.; Boppart, S. A., Optical frequency up-conversion by supercontinuum-free widely-tunable fiber-optic Cherenkov radiation. Optics Express 2009, 17, 9858-9872.

    • Liang, X.; Crecea, V.; Orenscanin, M.; Insana, M. F.; Boppart, S. A., Measurements of biomechanics by dynamic optical coherence elastography. Optics and Photonics News 2009, 20, (12), 18.

    • Liang, X.; Graf, B. W.; Boppart, S. A., Imaging engineered tissues using structural and functional optical coherence tomography. Journal of Biophotonics 2009, 2, (11), 643-655.

    • Liang, X.; Orescanin, M.; Toohey, K. S.; Insana, M. F.; Boppart, S. A., Acoustomotive optical coherence elastography for measuring material mechanical properties. Optics Letters 2009, 34, (19), 2894-2896.

    • Marks, D. L.; Geddes, J. B.; Boppart, S. A., Molecular identification by generating coherence between molecular normal modes using stimulated Raman scattering. Optics Letters 2009, 34, (12), 1756-1758.

    • Oldenburg, A. L.; Hansen, M. N.; Ralston, T. S.; Wei, A.; Boppart, S. A., Imaging gold nanorods in excised human breast carcinoma by spectroscopic optical coherence tomography. Journal of Materials Chemistry 2009, 19, (35), 6407-6411.

  • 2008
    • Liang, X.; Oldenburg, A. L.; Crecea, V.; Chaney, E. J.; Boppart, S. A., Optical micro-scale mapping of dynamic biomechanical tissue properties. Optics Express 2008, 16, (15), 11052-11065.

    • Marks, D. L.; Chaney, E. J.; Boppart, S. A., Plastinated tissue samples as three-dimensional models for optical instrument characterization. Optics Express 2008, 16, (20), 16272-16283.

    • Ding, H. F.; Wang, Z.; Nguyen, F.; Boppart, S. A.; Popescu, G., Fourier Transform Light Scattering of Inhomogeneous and Dynamic Structures. Physical Review Letters 2008, 101, (23).

    • Ralston, T. S.; Marks, D. L.; Carney, P. S.; Boppart, S. A., Real-time interferometric synthetic aperture microscopy. Optics Express 2008, 16, (4), 2555-2569.

    • Tu, H.; Marks, D. L.; Jiang, Z.; Boppart, S. A., Photoscattering effect in supercontinuum-generating photonic crystal fiber. Applied Physics Letters 2008, 92, (6).

    • Tu, H. H.; Jiang, Z.; Marks, D. L.; Boppart, S. A., Anomalous bending effect in photonic crystal fibers. Optics Express 2008, 16, (8), 5617-5622.

    • Tu, H. H.; Koh, Y. L.; Marks, D. L.; Boppart, S. A., Localized waveguide formation in germanosilicate fiber transmitting femtosecond IR pulses. Journal of the Optical Society of America B-Optical Physics 2008, 25, (2), 274-278.

    • Davis, B. J.; Marks, D. L.; Ralston, T. S.; Carney, P. S.; Boppart, S. A.; Interferometric synthetic aperture microscopy: computed imaging for scanned coherent microscopy. Sensors 2008, 8, 3903-3931.

    • Marks, D. L.; Schlachter, S. C.; Zysk, A. M.; Boppart, S. A.; Group refractive index reconstruction with broadband interferometric confocal microscopy. JOSA A 2008, 25, 1156-1164.

    • Chelliyil, R. G.; Ralston, T. S.; Marks, D. L.; Boppart, S. A., High-speed processing architecture for spectral-domain optical coherence microscopy. Journal of Biomedical Optics 2008, 13, (4), 044013.

    • Oldenburg, A. L.; Crecea, V.; Rinne, S. A.; Boppart, S. A., Phase-resolved magnetomotive OCT for imaging nanomolar concentrations of magnetic nanoparticles in tissues. Optics Express 2008, 16, (15), 11525-11539.

    • Ralston, T. S.; Adie, S. G.; Marks, D. L.; Davis, B. J.; Carney, P. S.; Boppart, S. A., Real-time interferometric synthetic aperture microscopy for clinical applications. Optics in 2008, Optics and Photonics News 2008, 19, (32).

  • 2007
    • Davis, B. J.; Schlachter, S. C.; Marks, D. L.; Ralston, T. S.; Boppart, S. A.; Carney, P. S.; Nonparaxial vector-field modeling of optical coherence tomography and interferometric synthetic aperture microscopy. JOSA A 2007, 24, 2527-2542.

    • Oldenburg, A. L.; Xu, C. Y.; Boppart, S. A., Spectroscopic optical coherence tomography and microscopy. IEEE Journal of Selected Topics in Quantum Electronics 2007, 13, (6), 1629-1640.

    • Choi, J. H.; Nguyen, F. T.; Barone, P. W.; Heller, D. A.; Moll, A. E.; Patel, D.; Boppart, S. A.; Strano, M. S.; Multimodal biomedical imaging with asymmetric single-walled carbon nanotube/iron oxide nanoparticle complexes. Nano Letters 2007, 7, (4), 861-867.

    • Marks, D. L.; Ralston, T. S.; Boppart, S. A.; Carney, P. S. Inverse scattering for frequency-scanned full-field optical coherence tomography. Journal of the Optical Society of America a-Optics Image Science and Vision 2007, 24, (4), 1034-1041.

    • Ralston, T. S.; Marks, D. L.; Carney, P. S.; Boppart, S. A. Interferometric synthetic aperture microscopy. Nature Physics 2007, 3, (2), 129-134.

    • Tan, W.; Vinegoni, C.; Norman, J. J.; Desai, T. A.; Boppart, S. A. Imaging cellular responses to mechanical stimuli within three-dimensional tissue constructs. Microscopy Research and Technique 2007, 70, (4), 361-371.

    • Zysk, A. M.; Marks, D. L.; Liu, D. Y.; Boppart, S. A. Needle-based reflection refractometry of scattering samples using coherence-gated detection. Optics Express 2007, 15, (8), 4787-4794.

    • Zysk, A. M.; Nguyen, F. T.; Oldenburg, A. L.; Marks, D. L.; Boppart, S. A., Optical coherence tomography: a review of clinical development from bench to bedside. Journal of Biomedical Optics 2007, 12, (5).

    • Tu, H.; Marks, D. L.; Koh, Y. L.; Boppart, S. A., Stabilization of continuum generation from normally dispersive nonlinear optical fibers for a tunable broad bandwidth source for optical coherence tomography. Optics Letters 2007, 32, (14), 2037-2039.

Press

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