Catherine Murphy




Peter C. and Gretchen Miller Markunas Professor of Chemistry
Affiliate, Materials Science and Engineering
Affiliate, Micro and Nanotechnology Laboratory
Associate Director, Materials Research Laboratory


TREE Award, Research Corporation for Science Advancement (2015); Member, U.S. National Academy of Sciences (2015); Fellow, Royal Society of Chemistry (2014); Carol Tyler Award, International Precious Metals Institute (2013); James D. & Julia P. Morrison Lectureship, Carleton College (2012); Fellow, American Chemical Society (2011); Lucy W. Pickett Lecturer, Mount Holyoke College (2011); Inorganic Nanoscience Award, given by the Division of Inorganic Chemistry, American Chemical Society, (2011); AAAS Fellow (2008); USC Russell Award for Research in Science, Mathematics, and Engineering (2005); Outstanding Undergraduate Research Mentor Award, University of South Carolina (2003); Golden Key Faculty Award for the Integration of Research and Undergraduate Teaching (1998); Camille Dreyfus Teacher-Scholar Award (1998-2000); Alfred P. Sloan Foundation Research Fellow (1997-1999); Cottrell Scholar Award (1996-2001); National Science Foundation CAREER Award (1995-1998).


  • 2017
    • Burrows, N. D.; Harvey, S.; Idesis, F. A.; Murphy, C. J. Understanding the Seed-Mediated Growth of Gold Nanorods through a Fractional Factorial Design of Experiments, Langmuir, 2017 in press.
    • Falagan-Lotsch, P.; Grzincic, E. M.; Murphy, C. J. New Advances in Nanotechnology-based Diagnosis and Therapeutics for Breast Cancer: An Assessment of Active-Targeting Inorganic Nanoplatforms, Bioconjugate Chem. 2017, 28, 135-152.
    • Qiu, T. A.; Torelli, M. D.; Vartanian, A. M.; Rackstraw, N. B.; Buchman, J. T.; Jacob, L. M.; Murphy, C. J.; Hamers, R. J.; Haynes, C. L. Quantification of Free Polyelectrolytes Present in Colloidal Suspension Reveals Source of Toxic Responses for Polyelectrolyte-wrapped Gold Nanoparticles, Anal. Chem. 2017, 89, 1823-1830.
    • Qiu, T. A.; Nguyen, T.H. T. ; Hudson-Smith, N. V.; Clement, P. L.; Forester, D.; Frew, H.; Hang, M.N.; Murphy, C. J.; Hamers, R. J.; Feng, Z. V.; Haynes, C. L. Growth-Based Bacterial Viability Assay for Interference-free and High-Throughput Toxicity Screening of Nanomaterials, Anal. Chem. 2017, 89, 2057-2064.
    • Abtahi, S.M.H.; Burrows, N. D.; Idesis, F. A.; Murphy, C. J.; Saleh, N. B.; Vikesland, P. J. Sulfate Mediated End-to-End Assembly of Gold Nanorods, Langmuir 2017, 33, 1486-1495.
  • 2016
    • Falagan-Lotsch, P.; Grzincic, E. M.; Murphy, C. J. One Low-Dose Exposure of Gold Nanoparticles Induces Long-Term Changes in Human Cells, Proc. Natl. Acad. Sci. USA 2016, 113, 13318-13323.
    • Burrows, N. D.; Lin, W.; Hinman, J. G.; Dennison, J. M.; Vartanian, A. M.; Abadeer, N. S.; Grzincic, E. M.; Jacob, L. M.; Li, J.; Murphy, C. J. Surface Chemistry of Gold Nanorods, Langmuir 2016, 32, 9905-9921.
    • Hinman, J. G.; Stork, A. J.; Varnell, J. A.; Gewirth. A. A.; Murphy, C. J. Seed-Mediated Growth of Gold Nanorods: Towards Nanorod Matryoshkas, Faraday Disc. 2016, 191, 9-33.
    • Gao, Z.; Burrows, N. D.; Valley, N. A.; Schatz, G. C.; Murphy, C. J.; Haynes, C. L. In Solution SERS Sensing Using Mesoporous Silica-Coated Gold Nanorods, Analyst 2016, 141, 5088-5095.
    • Holden, P. A.; Gardea-Torresdey, J.; Klaessig, F.; Turco, R. F.; Mortimer, M.; Hund-Rinke, K.; Hubal, E. A. C.; Avery, D.; Barcelo, D.; Behra, R.; Cohen, Y.; Deydier-Stephan, L.; Ferguson, P. L.; Frenandes, T. F.; Harthorn, B. H.; Henderson, W. M.; Hoke, R. A.; Hristozov, D.; Johnston, J. M.; Kane, A. B.; Kapustka, L.; Keller, A. A.; Lenihan, H. S.; Lovell, W.; Murphy, C. J.; Nisbet, R. M.; Petersen, E. J.; Salinas, E. R.; Scheringer, M.; Sharma, M.; Speed, D. E.; Sultan, Y.; Westerhoff, P.; White, J. C.; Wiesner, M. R.; Wong, E. M.; Xing, B.; Horan, M. S.; Godwin, H. A.; Nel, A. E. Considerations of Environmentally Relevant Test Conditions for Improved Evaluation of Ecological Hazard of Engineered Nanomaterials, Environ. Sci. Technol. 2016, 50, 6124-6145.
    • Afrooz, A. R. M. N.; Das, D.; Murphy, C. J.; Vikesland, P.; Saleh, N. B. Co-Transport of Gold Nanospheres with Single-Walled Carbon Nanotubes in Saturated Porous Media, Water Res. 2016, 99, 7-15.
    • Troiano, J. M.; Kuech, T. R.; Vartanian, A. M.; Torelli, M. D.; Sen, A.; Jacob, L. M.; Hamers, R. J.; Murphy, C. J.; Pedersen, J. A.; Geiger, F. M. On Electronic and Charge Interference in Second Harmonic Generation Reponses from Gold Metal Nanoparticles at Supported Lipid Bilayers, J. Phys. Chem. C 2016, 120, 20659-20667.
    • Wu, X.; Ni, Y.; Zhu, J.; Burrows, N. D.; Murphy, C. J.; Dumitrica, T.; Wang, X. Thermal Transport across Surfactant Layers on Gold Nanorods in Aqueous Solution, ACS Appl. Mater. Interfac. 2016, 8, 10581-10589.
    • Abadeer, N. S.; Murphy, C. J. Recent Progress in Cancer Thermal Therapy Using Gold Nanoparticles. J. Phys. Chem. C 2016, 120, 4691-4716.
    • Burrows, N. D.; Vartanian, A. M.; Abadeer, N.S.; Grzincic, E. M.; Jacob, L. M.; Lin, W.; Li, J.; Dennison, J. M.; Hinman, J. G.; Murphy, C. J. Anisotropic Nanoparticles and Anisotropic Surface Chemistry, J. Phys. Chem. Lett. 2016, 7, 632-641.
    • Mahmoud, M.; Lohse, S. E.; Murphy, C. J.; Suslick, K. S. Identification of Nanoparticles with a Colorimetric Sensor Array, ACS Sensors 2016, 1, 17-21.
    • Melby, E.; Mensch, A.; Lohse, S. E.; Peng, D.; Orr, G.; Murphy, C. J.; Hamers, R. J.; Pedersen, J. Formation of Supported Lipid Bilayers Containing Model Rafts and Their Interaction with Gold Nanoparticles, Environ. Sci.: Nano 2016, 3, 45-55.
    • Grassian, V.H.; Haes, A. J.; Mudunkotuwa, I. A.; Demokritou, P.; Kane, A. B.; Murphy, C. J.; Hutchison, J. E.; Issacs, J. A.; Jun, Y.-S.; Karn, B.; Khondaker, S. I.; Larsen, S. C.; Lau, B. L. T.; Pettibone, J.; Sadik, O. A.; Saleh, N. B.; Teague, C. NanoEHS – Defining Fundamental Science Needs: No Easy Feat when the Simple Itself is Complex, Environ. Sci.: Nano 2016, 3, 15-27.
  • 2015
    • Abadeer, N. S.; Fulop, G.; Chen, S.; Kall, M.; Murphy, C. J. Interactions of Bacterial Lipopolysaccharides with Gold Nanorod Surfaces Investigated by Refractometric Sensing, ACS Appl. Mater. Interfac. 2015, 7, 24915-24925.
    • Lin, W.; Insley, T.; Tuttle, M. D.; Zhu, L.; Berthold, D. A.; Kral, P.; Rienstra, C. M.; Murphy, C. J. Control of Protein Orientation on Gold Nanoparticle Surfaces, J. Phys. Chem. C 2015, 119, 21035-21043.
    • Qiu, T. A.; Bozich, J. S.; Lohse, S. E.; Vartanian, A. M.; Jacob, L. M.; Meyer, B. M.; Gunsolus, I. L.; Niemuth, N. J.; Murphy, C. J.; Haynes, C. L.; Klaper, R. D. Gene Expression as an Indicator of the Molecular Response and Toxicity in the Bacterium Shewanella oneidensis and the Water Flea Daphnia magna Exposed to Functionalized Gold Nanoparticles, Environ. Sci.: Nano 2015, 2, 615-629.
    • Murphy, C. J.; Buriak, J. M. Best Practices for the Reporting of Colloidal Inorganic Nanomaterials, Chem. Mater. 2015, 27, 4911-4913.
    • Jacobson, K. H.; Gunsolus, I. L.; Kuech, T.R., Jr.; Troiano, J. M.; Melby, E. S.; Lohse, S. E.; Hu, D.H.; Chrisler, W. B.; Murphy, C. J.; Orr, G.; Geiger, F. M.; Haynes, C. L.; Pedersen, J. A. Lipopolysaccharide Density and Structure Governs the Extent and Distance of Nanoparticle Interaction with Actual and Model Bacterial Membranes, Environ. Sci. Technol. 2015, 49, 10642-10650.
    • Grzincic, E. M.; Murphy, C. J. Gold Nanorods Indirectly Promote Migration of Metastatic Human Breast Cancer Cells in Three-Dimensional Cultures, ACS Nano 2015, 9, 6801-6816.
    • Feng, Z. V.; Gunsolus, I. L.; Qiu, T. A.; Hurley, K. R.; Nyberg, L. H.; Johnson, K. P.; Vartanian, A. M.; Jacob, L. M.; Lohse, S. E.; Torelli, M. D.; Hamers, R. J.; Murphy, C. J.; Haynes, C. L. Impacts of Gold Nanoparticle Charge and Ligand Type on Surface Binding and Toxicity to Gram-Negative and Gram-Positive Bacteria, Chem. Sci. 2015, 6, 5186-5196.
    • Murphy, C. J.; Vartanian, A. M.; Geiger, F. M.; Hamers, R. J.; Pedersen, J.; Cui, Q.; Haynes, C. L.; Carlson, E. E.; Hernandez, R.; Klaper, R. D.; Orr, G.; Rosenzweig, Z. Biological Responses to Engineered Nanomaterials: Needs for the Next Decade, ACS Central Science 2015, 1, 117-123
    • Rankin, J.; Neelakantan, N.; Lundberg, K.; Grzincic, E.; Murphy, C. J.; Suslick, K. Magnetic, Fluorescent, and Copolymeric Silicone Microspheres, Adv.Sci. 2015, 2, 1500114.
    • Murph, S.; Murphy, C. J.; Leach, A.; Gall, K. A Possible Oriented Attachment Growth Mechanism for Silver Nanowire Formation, Cryst. Growth Des. 2015, 15, 1968-1974.
    • Dominguez, G. A.; Lohse, S. E.; Torelli, M. D.; Murphy, C. J.; Hamers, R. J.; Orr, G.; Klaper, R. D. Effects of Charge and Surface Ligand Properties of Nanoparticles on Oxidative Stress and Gene Expression within the Gut of Daphnia magna, Aquatic Toxicology 2015, 162, 1-9.
    • Torelli, M. D.; Putans, R. A.; Tan, Y.; Lohse, S. E.; Murphy, C. J.; Hamers, R. J. Quantitative Determination of Ligand Densities on Nanomaterials by X-Ray Photoelectron Spectroscopy, ACS Appl. Mater. Interfac. 2015, 7, 1720-1725.
    • Troiano, J. M.; Olenick, L. L.; Kuech T. R.; Melby, E. S.; Hu, D.; Lohse, S. E.; Mensch, A. C.; Dogangun, M.; Vartanian, A. M.; Torelli, M. D.; Ehimiaghe, E.; Walter, S. R.; Fu, L.; Anderton, C. R.; Zhu, Z.; Wang, H.; Orr, G.; Murphy, C. J.; Hamers, R. J.; Pedersen, J. A.; Geiger, F. M. Direct Probes of 4-nm Diameter Gold Nanoparticles Interacting with Supported Lipid Bilayers, J. Phys. Chem. B 2015, 119, 534-546.
    • Grzincic, E. M.; Yang, J. A.; Drnevitch, J.; Lotsch, P. F.; Murphy, C. J. Global Transcriptometic Analysis of Model Human Cell Lines Exposed to Surface-Modified Gold Nanoparticles: The Effect of Surface Chemistry, Nanoscale 2015, 7, 1349-1362.
    • DeVetter, B. M.; Mukherjee, P.; Murphy, C. J.; Bhargava, R. Measuring binding kinetics of aromatic thiolated molecules with nanoparticles via surface-enhanced Raman spectroscopy, Nanoscale, 2015, 7, 8766-8775.
  • 2014
    • DeVetter, B. M.; Sivapalan, S. T.; Patel, D.; Schlumerich, M.; Murphy, C. J.; Bhargava, R. Observation of Molecular Diffusion in Polyelectrolyte-Wrapped SERS Nanoprobes, Langmuir 2014, 30, 8931-8937.
    • DeVetter, B. M.; Bhargava, R.; Murphy, C. J., Computational Study of the Surface-Enhanced Raman Scattering from Silica-Coated Silver Nanowires. Photochemistry and Photobiology 2014, 90, (2), 415-418, DOI: 10.1111/php.12205.

    • Mahmoudi, M.; Lohse, S. E.; Murphy, C. J.; Fathizadeh, A.; Montazeri, A.; Suslick, K. S., Variation of Protein Corona Composition of Gold Nanoparticles Following Plasmonic Heating. Nano Letters 2014, 14, (1), 6-12, DOI: 10.1021/nl403419e.

    • Alkilany, A. M.; Bani Yaseen, A. I.; Park, J.; Eller, J. R.; Murphy, C. J. Facile Transfer of Gold Nanoparticles from Aqueous Solutions to Organic Solvents with Thiolated Poly(ethylene glycol), RSC Adv. 2014, 4, 52676-52679.
    • Bishop, L. M.; Tillman, A. S.; Geiger, F. M.; Haynes, C. L.; Klaper, R. D.; Murphy, C. J.; Orr, G.; Pedersen, J. A.; DeStefano, L.; Hamers, R. J. Enhancing Graduate Student Communication to General Audiences through Blogging about Nanotechnology and Sustainability, J. Chem. Ed. 2014, 91, 1600-1605.
    • Abadeer, N. S.; Brennan, M. R.; Wilson, W. L.; Murphy, C. J. Distance and Plasmon Wavelength Dependent Fluorescence of Molecules Bound to Silica-Coated Gold Nanorods, ACS Nano 2014, 8, 8392-8406.
    • Alkilany, A. M.; Boulos, S. P.; Lohse, S. E.; Thompson, L. B.; Murphy, C. J. Homing-Peptide- Conjugated Gold Nanorods: How Good is Molecular Targeting and Display for Controlling Cellular Uptake and Proliferation? Bioconjugate Chem. 2014, 25, 1162-1171.
    • Bozich, J. S.; Lohse, S. E.; Torelli, M. D.; Murphy, C. J.; Hamers, R. J.; Klaper, R. D. Surface Chemistry, Charge, and Ligand Type Impact the Toxicity of Gold Nanoparticles to Daphina magna, Environ. Sci.: Nano 2014, 1, 260-270.
    • Kim, D.; Campos, A. R.; Datt, A.; Gao, Z.; Rycenga, M.; Burrows, N. D.; Greeneltch, N. G.; Mirkin, C. A.; Murphy, C. J.; van Duyne, R. P.; Haynes, C. L. Microfluidic-SERS Devices for One Shot Limit-of-Detection, Analyst 2014, 3227-3234.
    • Gunsolus, I.; Hu, D.; Mihai, C.; Lohse, S. E.; Lee, C-S.; Torelli, M.; Hamers, R. J.; Murphy, C. J.; Orr, G.; Haynes, C. L. Facile Method to Stain the Bacterial Cell Surface for Super-Resolution Fluorescence Microscopy, Analyst 2014, 139, 3174-3178.
    • Yang, J. A.; Lin, W.; Woods, W. S.; George, J. M.; Murphy, C. J. a-Synuclein’s Adsorption, Conformation and Orientation on Cationic Gold Nanoparticle Surfaces Seeds Global Conformational Change, J. Phys. Chem. B 2014, 118, 3359-3571.
    • Bogart, L. K,; Pourroy, G.; Murphy, C. J. Puntes, V.; Pellegrino, T.; Rosenblum, D.; Peer, D.; Levy, R. Nanoparticles for Imaging, Sensing, Therapeutic Intervention, ACS Nano 2014, 3107–3122.
  • 2013
    • Sivapalan, S. T.; DeVetter, B. M.; Yang, T. K.; Schulmerich, M. V.; Bhargava, R.; Murphy, C. J., Surface-Enhanced Raman Spectroscopy of Polyelectrolyte-Wrapped Gold Nanoparticles in Colloidal Suspension. Journal of Physical Chemistry C 2013, 117, (20), 10677-10682, DOI: 10.1021/jp402392y.

    • van Dijk, T.; Sivapalan, S. T.; DeVetter, B. M.; Yang, T. K.; Schulmerich, M. V.; Murphy, C. J.; Bhargava, R.; Carney, P. S. Competition Between Extinction and Enhancement if Surface- Enhanced Raman Spectroscopy, J. Phys. Chem. Lett. 2013, 3, 1193-1196. DOI: 10.1021/jz4005043.
    • Shah, A. B.; Sivapalan, S. T.; DeVetter, B. M.; Yang, T. K.; Wen, J.; Bhargava, R.; Murphy, C. J.; Zuo, J-M. High-Index Facets in Gold Nanocrystals Elucidated by Coherent Electron Diffraction, NanoLetters 2013, 13, 1840-1846. DOI:10.1021/nl400609t.
    • Sivapalan, S. T.; DeVetter, B. M.; Yang, T. K.; van Dijk, T.; Schulmerich, M. V.; Carney, P. S.; Bhargava, R.; Murphy, C. J. Off-resonance surface-enhanced Raman spectroscopy from gold nanorod suspensions as a function of aspect ratio: not what we thought, ACS Nano 2013, 7, 2099-2105. DOI:10.1021/nn305710k.
    • Boulos, S. P.; Prigozhin, M. B.; Liu, Y.; Wirth, A. J.; Boppart, S. A.; Gruebele, M.; Murphy, C. J. The Gold Nanorod-Biology Interface: From Proteins to Cells to Tissue, Curr. Phys. Chem. 2013, 3, 128-135. DOI:10.2174/1877946811303020002.


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